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AMR Drug RepurposingSmart Screeningresearch prototype

Sulfamethoxazole

FDA-approved product (tablet, oral), marketed as Gantanol, Gantanol-Ds, Sulfamethoxazole and 1 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sulfamethoxazole
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Intermediate-acting sulfonamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EC01

Repurposing investigation

Sulfamethoxazole is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae5.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 17 lab records
Open Sulfamethoxazole in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sulfamethoxazole with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • CleanUP IPF for the Pulmonary Trials Cooperative

    NCT02759120 · start 2017-03-22

    Registered record
    Registry ID
    NCT02759120
    Conditions
    Idiopathic Pulmonary Fibrosis
    Interventions
    Antimicrobial therapy: Co-trimoxazole or Doxycycline; No Intervention: Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2017-03-22
    Completion
    2020-03-16
    Enrolment
    513

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIdiopathic Pulmonary Fibrosis
    InterventionAntimicrobial therapy: Co-trimoxazole or Doxycycline; No Intervention: Standard of Care
    PhasePhase 3
    Registry statusTerminated

  • A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis

    NCT02879981 · start 2016-11-10

    Registered record
    Registry ID
    NCT02879981
    Conditions
    Bronchitis
    Interventions
    Guaifenesin; Sulfamethoxazole; Trimethoprim
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-11-10
    Completion
    2017-08-28
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchitis
    InterventionGuaifenesin; Sulfamethoxazole; Trimethoprim
    PhaseNot recorded
    Registry statusCompleted

  • Antibiotics and Tissue Expanders in Breast Reconstruction

    NCT01899690 · start 2016-06

    Registered record
    Registry ID
    NCT01899690
    Conditions
    Complications; Breast Prosthesis, Infection or Inflammation
    Interventions
    antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2016-06
    Completion
    2017-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplications; Breast Prosthesis, Infection or Inflammation
    Interventionantibiotic
    PhasePhase 4
    Registry statusWithdrawn

  • Initiation of a Deceased Donor Uterine Transplantation Program at the University of Nebraska Medical Center

    NCT02409147 · start 2016-01

    Registered record
    Registry ID
    NCT02409147
    Conditions
    Uterus Transplant
    Interventions
    Uterine Transplant
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2016-01
    Completion
    2018-07-24
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterus Transplant
    InterventionUterine Transplant
    PhaseNot applicable
    Registry statusWithdrawn

  • Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2

    NCT02829060 · start 2016-01

    Registered record
    Registry ID
    NCT02829060
    Conditions
    Nephrolithiasis; Urinary Tract Infection (UTI); Sepsis
    Interventions
    Nitrofurantoin 100 MG, 7d; Gentamicin, 5mg/kg; Ampicillin 2g; Nitrofurantoin 100 mg, 48 hrs; Gentamicin, 80 mg, 7d; Gentamicin, 80 mg, 48hr
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-01
    Completion
    2025-03
    Enrolment
    330

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephrolithiasis; Urinary Tract Infection (UTI); Sepsis
    InterventionNitrofurantoin 100 MG, 7d; Gentamicin, 5mg/kg; Ampicillin 2g; Nitrofurantoin 100 mg, 48 hrs +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotic Use in Distal Hypospadias Repair

    NCT03275519 · start 2015-01-19

    Registered record
    Registry ID
    NCT03275519
    Conditions
    Hypospadias
    Interventions
    Randomization to not receive prophylactic antibiotics after surgery.; Randomization to receive prophylactic antibiotics after surgery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01-19
    Completion
    2017-04-19
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypospadias
    InterventionRandomization to not receive prophylactic antibiotics after surgery.; Randomization to receive prophylactic antibiotics after surgery
    PhaseNot applicable
    Registry statusCompleted

  • Can Probiotics be Used in the Prevention of Recurrent UTI in Paediatric Neurogenic Bladder

    NCT02044965 · start 2015-01

    Registered record
    Registry ID
    NCT02044965
    Conditions
    Urinary Tract Infection
    Interventions
    Antibiotic; Probiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2023-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection
    InterventionAntibiotic; Probiotic
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Phase I Study of Safety and Immunogenicity of ADU-623

    NCT01967758 · start 2014-01-08

    Registered record
    Registry ID
    NCT01967758
    Conditions
    Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    Interventions
    Cohort 1; Cohort 2; Cohort 3; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01-08
    Completion
    2018-08-15
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAstrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    InterventionCohort 1; Cohort 2; Cohort 3; Antibiotics
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetic Parameters of Co-trimoxazole

    NCT01832987 · start 2013-10

    Registered record
    Registry ID
    NCT01832987
    Conditions
    Tuberculosis
    Interventions
    co-trimoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-10
    Completion
    2014-08
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    Interventionco-trimoxazole
    PhasePhase 2
    Registry statusCompleted

  • Efficacy of Fosfomycin-Trometamol in Urinary Tract Infection Prophylaxis After Kidney Transplantation

    NCT01820897 · start 2013-04

    Registered record
    Registry ID
    NCT01820897
    Conditions
    Urinary Tract Infection; Asymptomatic Bacteriuria; Allograft Rejection; Microbiologic Resistance; Hospitalization
    Interventions
    Fosfomycin-Trometamol; Sulfamethoxazole trimethoprim
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-04
    Completion
    2015-03
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection; Asymptomatic Bacteriuria; Allograft Rejection; Microbiologic Resistance +1 more
    InterventionFosfomycin-Trometamol; Sulfamethoxazole trimethoprim
    PhasePhase 4
    Registry statusCompleted

  • Antibiotic Prophylaxis When Removing Ureteric Stent After Stone Surgery

    NCT01768364 · start 2013-01

    Registered record
    Registry ID
    NCT01768364
    Conditions
    Ureteric Stent After Stone Surgery
    Interventions
    Trimetoprim-Sulfa (Bactrim); No antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-01
    Completion
    2016-04
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUreteric Stent After Stone Surgery
    InterventionTrimetoprim-Sulfa (Bactrim); No antibiotics
    PhaseNot applicable
    Registry statusUnknown

  • Clarithromycin, Sulfamethoxazole/Trimethoprim or Observation in Newly Diagnosed Multiple Myeloma

    NCT02624440 · start 2013-01

    Registered record
    Registry ID
    NCT02624440
    Conditions
    Multiple Myeloma; Infection
    Interventions
    Standard myeloma treatment; Clarithromycin; Sulfamethoxazole/trimethoprim; Observation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2013-01
    Completion
    2017-07
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma; Infection
    InterventionStandard myeloma treatment; Clarithromycin; Sulfamethoxazole/trimethoprim; Observation
    PhasePhase 2
    Registry statusUnknown

  • The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children"

    NCT01595529 · start 2012-05-18

    Registered record
    Registry ID
    NCT01595529
    Conditions
    Urinary Tract Infection
    Interventions
    Cefixime; Cephalexin; Placebo; Trimethoprim/Sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-05-18
    Completion
    2019-08-12
    Enrolment
    717

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection
    InterventionCefixime; Cephalexin; Placebo; Trimethoprim/Sulfamethoxazole
    PhasePhase 2
    Registry statusCompleted

  • Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)

    NCT01560052 · start 2012-05-05

    Registered record
    Registry ID
    NCT01560052
    Conditions
    IgA Glomerulonephritis
    Interventions
    methylprednisolone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-05-05
    Completion
    2021-07-23
    Enrolment
    503

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIgA Glomerulonephritis
    Interventionmethylprednisolone; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • D Mannose in Recurrent Urinary Tract Infections

    NCT01808755 · start 2012-01

    Registered record
    Registry ID
    NCT01808755
    Conditions
    Recurrent Urinary Tract Infection
    Interventions
    D Mannose; trimethoprim/sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-01
    Completion
    2012-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Urinary Tract Infection
    InterventionD Mannose; trimethoprim/sulfamethoxazole
    PhasePhase 3
    Registry statusCompleted