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AMR Drug RepurposingSmart Screeningresearch prototype

Sulfamethoxazole

FDA-approved product (tablet, oral), marketed as Gantanol, Gantanol-Ds, Sulfamethoxazole and 1 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sulfamethoxazole
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Intermediate-acting sulfonamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EC01

Repurposing investigation

Sulfamethoxazole is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae5.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 17 lab records
Open Sulfamethoxazole in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sulfamethoxazole with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS

    NCT00000715

    Registered record
    Registry ID
    NCT00000715
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Pentamidine isethionate; Sulfamethoxazole-Trimethoprim
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1991-09
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionPentamidine isethionate; Sulfamethoxazole-Trimethoprim
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

    NCT00000730

    Registered record
    Registry ID
    NCT00000730
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Methylprednisolone; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    Not recorded
    Completion
    1989-03
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Methylprednisolone; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim +1 more
    PhasePhase 3
    Registry statusTerminated

  • Evaluation of the Interaction Between Low Dose Sulfamethoxazole-Trimethoprim and Zidovudine

    NCT00000732

    Registered record
    Registry ID
    NCT00000732
    Conditions
    HIV Infections
    Interventions
    Sulfamethoxazole-Trimethoprim; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1990-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionSulfamethoxazole-Trimethoprim; Zidovudine
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of the Interaction Between High Dose Sulfamethoxazole/Trimethoprim and Zidovudine

    NCT00000734

    Registered record
    Registry ID
    NCT00000734
    Conditions
    HIV Infections
    Interventions
    Sulfamethoxazole-Trimethoprim; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1990-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionSulfamethoxazole-Trimethoprim; Zidovudine
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Children Who Cannot Take Trimethoprim-Sulfamethoxazole

    NCT00001027

    Registered record
    Registry ID
    NCT00001027
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Pentamidine isethionate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1996-09
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionPentamidine isethionate
    PhasePhase 1
    Registry statusCompleted