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AMR Drug RepurposingSmart Screeningresearch prototype

Sulfamethoxazole

FDA-approved product (tablet, oral), marketed as Gantanol, Gantanol-Ds, Sulfamethoxazole and 1 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sulfamethoxazole
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Intermediate-acting sulfonamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EC01

Repurposing investigation

Sulfamethoxazole is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae5.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 17 lab records
Open Sulfamethoxazole in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sulfamethoxazole with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

    NCT01349192 · start 2011-04

    Registered record
    Registry ID
    NCT01349192
    Conditions
    Cystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    Interventions
    Rifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin; chlorhexidine gluconate oral rinse; 2% Chlorhexidine solution wipes; Environmental Decontamination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-04
    Completion
    2015-05
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    InterventionRifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin +3 more
    PhasePhase 2
    Registry statusTerminated

  • Chemopreventive Therapy for Malaria in Ugandan Children

    NCT00948896 · start 2010-06

    Registered record
    Registry ID
    NCT00948896
    Conditions
    Malaria
    Interventions
    trimethoprim-sulfamethoxazole (TS; TMP/SMX); sulfadoxine-pyrimethamine (SP); dihydroartemisinin-piperaquine (DP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-06
    Completion
    2014-04
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    Interventiontrimethoprim-sulfamethoxazole (TS; TMP/SMX); sulfadoxine-pyrimethamine (SP); dihydroartemisinin-piperaquine (DP)
    PhasePhase 3
    Registry statusCompleted

  • Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess

    NCT01498744 · start 2010-02

    Registered record
    Registry ID
    NCT01498744
    Conditions
    Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    Interventions
    Oral Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2013-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    InterventionOral Clindamycin
    PhaseNot applicable
    Registry statusTerminated

  • Single Dose Monurol for Treatment of Acute Cystitis

    NCT00976963 · start 2009-09-17

    Registered record
    Registry ID
    NCT00976963
    Conditions
    Urinary Tract Infection
    Interventions
    TMP/SMX; Fosfomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09-17
    Completion
    2016-12-27
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection
    InterventionTMP/SMX; Fosfomycin
    PhaseNot applicable
    Registry statusCompleted

  • Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda

    NCT00674921 · start 2008-06

    Registered record
    Registry ID
    NCT00674921
    Conditions
    HIV Infections
    Interventions
    cotrimoxazole; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-06
    Completion
    2011-06
    Enrolment
    1,650

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    Interventioncotrimoxazole; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Prospective Randomized Trial of Bactrim on 7 Day Outcome in Patients With Uncomplicated Abscesses

    NCT00973765 · start 2007-11

    Registered record
    Registry ID
    NCT00973765
    Conditions
    Abscesses
    Interventions
    bactrim; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-08
    Enrolment
    212

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscesses
    Interventionbactrim; placebo
    PhasePhase 3
    Registry statusCompleted

  • Orally Administered Trimethoprim-sulfamethoxazole and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery

    NCT00613769 · start 2007-09

    Registered record
    Registry ID
    NCT00613769
    Conditions
    Infection Prophylaxis in Colo Rectal Surgery
    Interventions
    trimethoprim-sulfamethoxazole + metronidazole; cefuroxime and metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-09
    Completion
    2012-05
    Enrolment
    1,073

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection Prophylaxis in Colo Rectal Surgery
    Interventiontrimethoprim-sulfamethoxazole + metronidazole; cefuroxime and metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis

    NCT02123628 · start 2007-06

    Registered record
    Registry ID
    NCT02123628
    Conditions
    Diabetes Mellitus
    Interventions
    duration of the antibiotic therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-06
    Completion
    2012-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus
    Interventionduration of the antibiotic therapy
    PhasePhase 4
    Registry statusCompleted

  • Computer Stop Order Alert to Prevent Concurrent Prescribing of Trimethoprim/Sulfamethoxazole and Warfarin

    NCT00870298 · start 2006-08

    Registered record
    Registry ID
    NCT00870298
    Conditions
    Prescribers' Drug Orders
    Interventions
    Trimethoprim/Sulfamethoxazole and Warfarin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2006-08
    Completion
    2007-01
    Enrolment
    1,971

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrescribers' Drug Orders
    InterventionTrimethoprim/Sulfamethoxazole and Warfarin
    PhaseNot applicable
    Registry statusTerminated

  • Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV

    NCT00080119 · start 2004-02

    Registered record
    Registry ID
    NCT00080119
    Conditions
    HIV Infection; Tuberculosis; Pneumocystis Jiroveci Pneumonia
    Interventions
    Isoniazid (INH); Trimethoprim/Sulfamethoxazole (TMP/SMX); Isoniazid Placebo (PL)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2004-02
    Completion
    2009-05
    Enrolment
    1,354

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection; Tuberculosis; Pneumocystis Jiroveci Pneumonia
    InterventionIsoniazid (INH); Trimethoprim/Sulfamethoxazole (TMP/SMX); Isoniazid Placebo (PL)
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • VNP20009 in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Therapy

    NCT00004216 · start 1999-08

    Registered record
    Registry ID
    NCT00004216
    Conditions
    Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    salmonella VNP20009; cefixime; ceftriaxone sodium; ciprofloxacin; trimethoprim-sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    1999-08
    Completion
    2008-01
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnspecified Adult Solid Tumor, Protocol Specific
    Interventionsalmonella VNP20009; cefixime; ceftriaxone sodium; ciprofloxacin +1 more
    PhasePhase 1
    Registry statusCompleted

  • High Dose Sequential Therapy and Autologous Stem Cell Rescue for Multiple Myeloma

    NCT00586014 · start 1997-05

    Registered record
    Registry ID
    NCT00586014
    Conditions
    Multiple Myeloma
    Interventions
    High-Dose Sequential Chemotherapy followed by ASCT
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1997-05
    Completion
    2008-02
    Enrolment
    91

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma
    InterventionHigh-Dose Sequential Chemotherapy followed by ASCT
    PhasePhase 2
    Registry statusCompleted

  • Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy

    NCT00002850 · start 1997-03

    Registered record
    Registry ID
    NCT00002850
    Conditions
    Infection; Multiple Myeloma
    Interventions
    ciprofloxacin; ofloxacin; 160 mg trimethoprim and 800 mg sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1997-03
    Completion
    2012-01
    Enrolment
    212

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Multiple Myeloma
    Interventionciprofloxacin; ofloxacin; 160 mg trimethoprim and 800 mg sulfamethoxazole
    PhasePhase 3
    Registry statusCompleted

  • Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

    NCT00002610 · start 1996-01

    Registered record
    Registry ID
    NCT00002610
    Conditions
    Kidney Cancer
    Interventions
    dactinomycin; filgrastim; carboplatin; cyclophosphamide; doxorubicin hydrochloride; etoposide; vincristine sulfate; conventional surgery; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1996-01
    Completion
    2006-02
    Enrolment
    203

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Cancer
    Interventiondactinomycin; filgrastim; carboplatin; cyclophosphamide +5 more
    PhasePhase 3
    Registry statusCompleted

  • A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients

    NCT00000655

    Registered record
    Registry ID
    NCT00000655
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Atovaquone; Sulfamethoxazole-Trimethoprim
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionAtovaquone; Sulfamethoxazole-Trimethoprim
    PhasePhase 2
    Registry statusCompleted