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AMR Drug RepurposingSmart Screeningresearch prototype

Quinapril Hydrochloride

FDA-approved product (tablet, oral), marketed as Accupril, Quinapril Hydrochloride.

Registered studies
33
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Quinapril Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • Kidney failure
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA35.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli33.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae15.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

33registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Quinapril Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quinapril Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Quinapril 40 mg With Alpha Lipoic Acid or Placebo on Diabetes and Hypertension

    NCT00795262 · start 2008-07

    Registered record
    Registry ID
    NCT00795262
    Conditions
    Diabetes; Hypertension
    Interventions
    Quinapril (Accupril) plus Alpha Lipoic Acid; accupril, placebo; accupril, alpha lipoic acid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-07
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes; Hypertension
    InterventionQuinapril (Accupril) plus Alpha Lipoic Acid; accupril, placebo; accupril, alpha lipoic acid
    PhaseNot applicable
    Registry statusCompleted

  • A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM

    NCT00980187 · start 2008-03

    Registered record
    Registry ID
    NCT00980187
    Conditions
    Hypertension; Type 2 Diabetes Mellitus
    Interventions
    Hydrochlorothiazide; Indapamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    2010-08
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Type 2 Diabetes Mellitus
    InterventionHydrochlorothiazide; Indapamide
    PhasePhase 4
    Registry statusCompleted

  • Bioequivalence Study of Quinapril Hydrochloride 20 mg and Hydrochlorothiazide 25 mg Tablets Under Fasting Conditions

    NCT00872781 · start 2007-10

    Registered record
    Registry ID
    NCT00872781
    Conditions
    Healthy
    Interventions
    fixed dose combination of Quinapril HCl 20 mg and Hydrochlorothiazide 25 mg tablets
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-10
    Completion
    2007-12
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionfixed dose combination of Quinapril HCl 20 mg and Hydrochlorothiazide 25 mg tablets
    PhaseNot applicable
    Registry statusCompleted

  • High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients

    NCT00313547 · start 2006-04

    Registered record
    Registry ID
    NCT00313547
    Conditions
    Hypertension
    Interventions
    Quinapril 40 mg; Quinapril 10 mg and amlodipine 5 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-04
    Completion
    2008-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionQuinapril 40 mg; Quinapril 10 mg and amlodipine 5 mg
    PhasePhase 4
    Registry statusTerminated

  • Bioequivalence Study of Quinapril Hydrochloride 20 mg and Hydrochlorothiazide 25 mg Tablets Under Fed Conditions

    NCT00872235 · start 2005-06

    Registered record
    Registry ID
    NCT00872235
    Conditions
    Healthy
    Interventions
    fixed-dose combination of quinapril 20 mg and hydrochlorothiazide 25 mg tablets
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-06
    Completion
    2005-11
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionfixed-dose combination of quinapril 20 mg and hydrochlorothiazide 25 mg tablets
    PhaseNot applicable
    Registry statusCompleted

  • High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty

    NCT00154050 · start 2004-05

    Registered record
    Registry ID
    NCT00154050
    Conditions
    Arterial Occlusive Diseases
    Interventions
    candesartan (drug) or quinapril (drug)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-05
    Completion
    2006-07
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArterial Occlusive Diseases
    Interventioncandesartan (drug) or quinapril (drug)
    PhaseNot applicable
    Registry statusCompleted

  • Non-Comparative Study To Evaluate Changes In FMD After Quinapril Therapy In Hypertensive Women

    NCT00147524 · start 2003-10

    Registered record
    Registry ID
    NCT00147524
    Conditions
    Menopause; Hypertension
    Interventions
    quinapril; Laser Doppler imaging
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-10
    Completion
    2005-05
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMenopause; Hypertension
    Interventionquinapril; Laser Doppler imaging
    PhasePhase 4
    Registry statusCompleted

  • Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

    NCT00684489 · start 2003-09

    Registered record
    Registry ID
    NCT00684489
    Conditions
    Hypertension
    Interventions
    clinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-09
    Completion
    2005-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    PhaseNot applicable
    Registry statusCompleted

  • Food Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg

    NCT00648011 · start 2003-08

    Registered record
    Registry ID
    NCT00648011
    Conditions
    Healthy
    Interventions
    Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg; Accuretic™ Tablets 20 mg/25 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-08
    Completion
    2003-09
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg; Accuretic™ Tablets 20 mg/25 mg
    PhasePhase 1
    Registry statusCompleted

  • Fasting Study of Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg to Accuretic™ Tablets 20 mg/25 mg

    NCT00649441 · start 2003-08

    Registered record
    Registry ID
    NCT00649441
    Conditions
    Healthy
    Interventions
    Quinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg; Accuretic™ Tablets 20 mg/25 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-08
    Completion
    2003-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinapril HCl and Hydrochlorothiazide Tablets 20 mg/25 mg; Accuretic™ Tablets 20 mg/25 mg
    PhasePhase 1
    Registry statusCompleted

  • Amlodipine Diabetic Hypertension Efficacy Response Trial

    NCT00159692 · start 2003-03

    Registered record
    Registry ID
    NCT00159692
    Conditions
    Hypertension
    Interventions
    Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-03
    Completion
    2005-08
    Enrolment
    739

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAmlodipine
    PhasePhase 4
    Registry statusCompleted

  • Fasting Study of Quinapril Hydrochloride Tablets 40 mg and Accupril® Tablets 40 mg

    NCT00649103 · start 2002-12

    Registered record
    Registry ID
    NCT00649103
    Conditions
    Healthy
    Interventions
    Quinapril Hydrochloride Tablets 40 mg; Accupril® Tablets 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2002-12
    Completion
    2003-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinapril Hydrochloride Tablets 40 mg; Accupril® Tablets 40 mg
    PhasePhase 1
    Registry statusCompleted

  • Food Study of Quinapril Hydrochloride Tablets 40 mg and Accupril® Tablets 40 mg

    NCT00649649 · start 2002-12

    Registered record
    Registry ID
    NCT00649649
    Conditions
    Healthy
    Interventions
    Quinapril Hydrochloride Tablets 40 mg; Accupril® Tablets 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2002-12
    Completion
    2003-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinapril Hydrochloride Tablets 40 mg; Accupril® Tablets 40 mg
    PhasePhase 1
    Registry statusCompleted

  • A Study to Evaluate the Efficacy and Safety of Quinapril or Quinapril Plus Hydrochlorothiazide in Patients With Mild to Moderate Hypertension

    NCT00651287 · start 2002-12

    Registered record
    Registry ID
    NCT00651287
    Conditions
    Hypertension
    Interventions
    quinapril 20 mg; quinapril 20 mg plus hydrochlorothiazide 12.5 mg; quinapril 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-12
    Completion
    2004-06
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionquinapril 20 mg; quinapril 20 mg plus hydrochlorothiazide 12.5 mg; quinapril 40 mg
    PhasePhase 4
    Registry statusCompleted

  • QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia

    NCT00150826 · start 2000-05

    Registered record
    Registry ID
    NCT00150826
    Conditions
    Ischemic Heart Disease
    Interventions
    Quinapril; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2000-05
    Completion
    2004-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Heart Disease
    InterventionQuinapril; Placebo
    PhasePhase 4
    Registry statusCompleted