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AMR Drug RepurposingSmart Screeningresearch prototype

Methylnaltrexone Bromide

FDA-approved product (solution, subcutaneous), marketed as Methylnaltrexone Bromide, Relistor.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Methylnaltrexone Bromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Constipation
  • Opioid dependence

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Peripheral opioid receptor antagonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA44.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Methylnaltrexone Bromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methylnaltrexone Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair

    NCT00528970 · start 2007-10-17

    Registered record
    Registry ID
    NCT00528970
    Conditions
    Ileus
    Interventions
    MOA-728; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-10-17
    Completion
    2008-02-05
    Enrolment
    374

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus
    InterventionMOA-728; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant Pain

    NCT00547586 · start 2007-10

    Registered record
    Registry ID
    NCT00547586
    Conditions
    Constipation
    Interventions
    N-methylnaltrexone bromide (MOA-728); placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-02
    Enrolment
    122

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation
    InterventionN-methylnaltrexone bromide (MOA-728); placebo
    PhasePhase 2
    Registry statusCompleted

  • Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain

    NCT00529087 · start 2007-08

    Registered record
    Registry ID
    NCT00529087
    Conditions
    Constipation
    Interventions
    N-methylnaltrexone bromide (MOA-728); placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-08
    Completion
    2008-12
    Enrolment
    460

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation
    InterventionN-methylnaltrexone bromide (MOA-728); placebo
    PhasePhase 3
    Registry statusCompleted

  • Study Evaluating IV Methylnaltrexone for the Treatment of Post Operative Ileus

    NCT00387309 · start 2006-12

    Registered record
    Registry ID
    NCT00387309
    Conditions
    Post Operative Bowel Dysfunction
    Interventions
    Methylnaltrexone (MOA-728)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12
    Completion
    2007-11
    Enrolment
    495

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Bowel Dysfunction
    InterventionMethylnaltrexone (MOA-728)
    PhasePhase 3
    Registry statusCompleted

  • Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)

    NCT00401375 · start 2006-10-31

    Registered record
    Registry ID
    NCT00401375
    Conditions
    Post-Operative Ileus (POI)
    Interventions
    Methylnaltrexone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-10-31
    Completion
    2008-02-29
    Enrolment
    524

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Operative Ileus (POI)
    InterventionMethylnaltrexone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study of Pharmacokinetics, Safety and Tolerability of Intravenous Methylnaltrexone Bromide

    NCT01366365 · start 2006-10

    Registered record
    Registry ID
    NCT01366365
    Conditions
    Healthy Adults
    Interventions
    methylnaltrexone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-10
    Completion
    2006-11
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Adults
    Interventionmethylnaltrexone; placebo
    PhasePhase 1
    Registry statusCompleted

  • Effects of MNTX on CYP450 2D6 in Metabolizers of Dextromethorphan

    NCT01367535 · start 2006-03

    Registered record
    Registry ID
    NCT01367535
    Conditions
    Healthy Adults
    Interventions
    SC Methylnaltrexone (MNTX); IV Methylnaltrexone (MNTX); Oral Paroxetine; SC Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2006-08
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Adults
    InterventionSC Methylnaltrexone (MNTX); IV Methylnaltrexone (MNTX); Oral Paroxetine; SC Placebo
    PhasePhase 1
    Registry statusCompleted

  • Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization

    NCT01363323 · start 2004-11

    Registered record
    Registry ID
    NCT01363323
    Conditions
    Healthy Volunteers
    Interventions
    Methylnaltrexone (MNTX); Methylnaltrexone (MNTX); Methylnaltrexone (MNTX); Placebo; Moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-11
    Completion
    2005-02
    Enrolment
    546

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionMethylnaltrexone (MNTX); Methylnaltrexone (MNTX); Methylnaltrexone (MNTX); Placebo +1 more
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function

    NCT01367509 · start 2004-03

    Registered record
    Registry ID
    NCT01367509
    Conditions
    Renal Impairment
    Interventions
    Methylnaltrexone (MNTX)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-03
    Completion
    2005-06
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Impairment
    InterventionMethylnaltrexone (MNTX)
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone in Volunteers With Impaired Hepatic Function

    NCT01367522 · start 2004-03

    Registered record
    Registry ID
    NCT01367522
    Conditions
    Liver Dysfunction
    Interventions
    SC Methylnaltrexone (MNTX)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-03
    Completion
    2004-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Dysfunction
    InterventionSC Methylnaltrexone (MNTX)
    PhasePhase 1
    Registry statusCompleted

  • Open-Label Treatment Extension of Protocol MNTX 302

    NCT01367613 · start 2004-03

    Registered record
    Registry ID
    NCT01367613
    Conditions
    Terminal Illness
    Interventions
    SC Methylnaltrexone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03
    Completion
    2006-01
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTerminal Illness
    InterventionSC Methylnaltrexone
    PhasePhase 3
    Registry statusCompleted

  • Study of Methylnaltrexone (MNTX) for the Relief of Constipation

    NCT00402038 · start 2004-02

    Registered record
    Registry ID
    NCT00402038
    Conditions
    Advance Illness Patients With OIC
    Interventions
    SC Methylnaltrexone; SC Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-02
    Completion
    2005-10
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdvance Illness Patients With OIC
    InterventionSC Methylnaltrexone; SC Placebo
    PhasePhase 3
    Registry statusCompleted

  • Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets

    NCT01366352 · start 2004-02

    Registered record
    Registry ID
    NCT01366352
    Conditions
    Normal Volunteers
    Interventions
    MNTX tablet (Formulation 1); MNTX tablet (Formulation 2)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-02
    Completion
    2004-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNormal Volunteers
    InterventionMNTX tablet (Formulation 1); MNTX tablet (Formulation 2)
    PhasePhase 1
    Registry statusCompleted

  • Tolerance and Pharmacokinetics Study of MNTX Tablets

    NCT01366339 · start 2003-10

    Registered record
    Registry ID
    NCT01366339
    Conditions
    Normal Healthy Volunteers
    Interventions
    Oral methylnaltrexone; Oral placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-10
    Completion
    2003-12
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNormal Healthy Volunteers
    InterventionOral methylnaltrexone; Oral placebo
    PhasePhase 1
    Registry statusCompleted

  • Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus

    NCT01367548 · start 2003-07

    Registered record
    Registry ID
    NCT01367548
    Conditions
    Postoperative Ileus
    Interventions
    IV Methylnaltrexone (MNTX); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-07
    Completion
    2004-12
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Ileus
    InterventionIV Methylnaltrexone (MNTX); Placebo
    PhasePhase 2
    Registry statusCompleted