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AMR Drug RepurposingSmart Screeningresearch prototype

Dutasteride

FDA-approved product (capsule, oral), marketed as Avodart, Dutasteride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Dutasteride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Benign prostatic hyperplasia
  • Prostate adenocarcinoma
  • Prostate carcinoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Testosterone-5-alpha reductase inhibitors
FDA pharmacologic class
5-alpha Reductase Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli39.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dutasteride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dutasteride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • AVODART® Alopecia Post-marketing Surveillance (PMS)

    NCT01004809 · start 2010-04-29

    Registered record
    Registry ID
    NCT01004809
    Conditions
    Alopecia
    Interventions
    Dutasteride
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-04-29
    Completion
    2012-12-21
    Enrolment
    712

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia
    InterventionDutasteride
    PhaseNot recorded
    Registry statusCompleted

  • Benign Prostatic Hypertrophy Treatment Patterns & Outcomes: Marketscan

    NCT01323998 · start 2010-04

    Registered record
    Registry ID
    NCT01323998
    Conditions
    Prostatic Hyperplasia
    Interventions
    5ARI; AB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-04
    Completion
    2010-06
    Enrolment
    35,032

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia
    Intervention5ARI; AB
    PhaseNot recorded
    Registry statusCompleted

  • Role of Dutasteride in Patients Undergoing 3D Mapping Biopsy in Early Stage Prostate Cancer

    NCT00985738 · start 2009-09

    Registered record
    Registry ID
    NCT00985738
    Conditions
    Prostate Cancer
    Interventions
    Dutasteride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-09
    Completion
    2013-01
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDutasteride; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Study Assessing The Efficacy And Safety Of Avodart (Dutasteride) At Improving Urinary Symptoms In Men With Prostate Cancer Who Are Undergoing Seed Implantation

    NCT00805701 · start 2009-01

    Registered record
    Registry ID
    NCT00805701
    Conditions
    Prostate Cancer
    Interventions
    avodart; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2014-04
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    Interventionavodart; Placebo
    PhasePhase 4
    Registry statusCompleted

  • ARTS - AVODART After Radical Therapy For Prostate Cancer Study

    NCT00558363 · start 2007-11

    Registered record
    Registry ID
    NCT00558363
    Conditions
    Neoplasms, Prostate; Prostate Cancer After a Radical Treatment
    Interventions
    Avodart; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2011-03
    Enrolment
    294

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeoplasms, Prostate; Prostate Cancer After a Radical Treatment
    InterventionAvodart; placebo
    PhasePhase 2
    Registry statusCompleted

  • A Study To Compare Giving AVODART And FLOMAX Together Or In A Combination Capsule In The Fed And Fasted State

    NCT00537654 · start 2007-10-18

    Registered record
    Registry ID
    NCT00537654
    Conditions
    Prostatic Hyperplasia
    Interventions
    Treatment sequence A; Treatment sequence B; Treatment sequence C; Treatment sequence D
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-10-18
    Completion
    2008-02-22
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia
    InterventionTreatment sequence A; Treatment sequence B; Treatment sequence C; Treatment sequence D
    PhasePhase 1
    Registry statusCompleted

  • Dutasteride 0.5mg For The Treatment Of Chinese Patients With Benign Prostatic Hyperplasia (BPH)

    NCT00527605 · start 2007-10

    Registered record
    Registry ID
    NCT00527605
    Conditions
    Benign Prostatic Hyperplasia; Prostatic Hyperplasia
    Interventions
    Dutasteride 0.5mg capsule; Dutasteride matched placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-10
    Completion
    2009-03
    Enrolment
    253

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia; Prostatic Hyperplasia
    InterventionDutasteride 0.5mg capsule; Dutasteride matched placebo
    PhasePhase 3
    Registry statusCompleted

  • Prostate Cancer Study In Men Who Have Failed First-Line Androgen Deprivation Therapy

    NCT00470834 · start 2007-05

    Registered record
    Registry ID
    NCT00470834
    Conditions
    Neoplasms, Prostate
    Interventions
    dutasteride; placebo; bicalutamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-05
    Completion
    2013-02
    Enrolment
    127

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeoplasms, Prostate
    Interventiondutasteride; placebo; bicalutamide
    PhasePhase 4
    Registry statusCompleted

  • Prevention of Prostate Cancer With Dutasteride in Case of High Grade PIN Neoplasia

    NCT00780754 · start 2007-04

    Registered record
    Registry ID
    NCT00780754
    Conditions
    Prostate Cancer
    Interventions
    dutasteride; prostate biopsy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2010-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    Interventiondutasteride; prostate biopsy
    PhasePhase 3
    Registry statusCompleted

  • Effects Of Dutasteride On Risk Reduction Of Acute Urinary Retention Relapse Following Trial Without Catheter

    NCT00421421 · start 2007-03

    Registered record
    Registry ID
    NCT00421421
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Dutasteride
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-03
    Completion
    Not recorded
    Enrolment
    276

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionDutasteride
    PhasePhase 4
    Registry statusTerminated

  • Effect of Dutasteride on Androgen-Response Gene Expression in Patients With Advanced Prostate Cancer

    NCT00668642 · start 2007-03

    Registered record
    Registry ID
    NCT00668642
    Conditions
    Prostate Cancer
    Interventions
    Dutasteride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-03
    Completion
    2013-05
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDutasteride; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Maximal Suppression of the Androgen Axis in Clinically Localized Prostate Cancer

    NCT00298155 · start 2006-07

    Registered record
    Registry ID
    NCT00298155
    Conditions
    Cancer; Prostate Neoplasms
    Interventions
    goserelin with dutasteride; goserelin with bicalutamide and dutasteride; goserelin with bicalutamide and dutasteride and ketoconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-07
    Completion
    2014-01
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer; Prostate Neoplasms
    Interventiongoserelin with dutasteride; goserelin with bicalutamide and dutasteride; goserelin with bicalutamide and dutasteride and ketoconazole
    PhasePhase 2
    Registry statusCompleted

  • Assessment Of Dutasteride (AVODART) In Extending The Time To Progression Of Low-Risk, Localized Prostate Cancer In Men

    NCT00363311 · start 2006-07

    Registered record
    Registry ID
    NCT00363311
    Conditions
    Neoplasms, Prostate
    Interventions
    Dutasteride; Matching placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2010-07
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeoplasms, Prostate
    InterventionDutasteride; Matching placebo
    PhasePhase 4
    Registry statusCompleted

  • Effect of Dutasteride on Bladder Wall Hypertrophy in Patients With Benign Prostatic Obstruction

    NCT00827814 · start 2006-06

    Registered record
    Registry ID
    NCT00827814
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Dutasteride
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2009-04
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionDutasteride
    PhasePhase 4
    Registry statusCompleted

  • Metabolic Effects of Steroids in Obese Men

    NCT00983554 · start 2005-06

    Registered record
    Registry ID
    NCT00983554
    Conditions
    Obesity; Insulin Resistance
    Interventions
    Anastrazole; Testosterone; Dutasteride; GnRH antagonist
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2005-06
    Completion
    2009-10
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Insulin Resistance
    InterventionAnastrazole; Testosterone; Dutasteride; GnRH antagonist
    PhaseNot applicable
    Registry statusUnknown