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AMR Drug RepurposingSmart Screeningresearch prototype

Vinblastine Sulfate

FDA-approved product (injectable, injection), marketed as Velban, Vinblastine Sulfate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Vinblastine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Classic Hodgkin lymphoma
  • Fungal infectious disease
  • Hodgkins lymphoma
  • Lymphoid neoplasm
  • Lymphoma
  • Neoplasm

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vinca alkaloids and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA61.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli48.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae38.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis70.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Vinblastine Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vinblastine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors

    NCT00274950 · start 2005-05

    Registered record
    Registry ID
    NCT00274950
    Conditions
    Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer
    Interventions
    bleomycin sulfate; carboplatin; cisplatin; etoposide; ifosfamide; vinblastine sulfate; adjuvant therapy; conventional surgery
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2005-05
    Completion
    Not recorded
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChildhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer
    Interventionbleomycin sulfate; carboplatin; cisplatin; etoposide +4 more
    PhasePhase 3
    Registry statusUnknown

  • Fludeoxyglucose F18 Positron Emission Tomography Imaging In Assessing Patients Before and After Treatment for Locally Advanced Non-Small Cell Lung Cancer

    NCT00083083 · start 2005-03

    Registered record
    Registry ID
    NCT00083083
    Conditions
    Lung Cancer
    Interventions
    carboplatin; cisplatin; docetaxel; etoposide; paclitaxel; vinblastine sulfate; vinorelbine tartrate; gene expression analysis; positron emission tomography; fludeoxyglucose F 18; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2005-03
    Completion
    Not recorded
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer
    Interventioncarboplatin; cisplatin; docetaxel; etoposide +7 more
    PhasePhase 2
    Registry statusUnknown

  • Study of Prednisone, Vinblastine, Doxorubicin, and Gemcitabine in Elderly Patients With Advanced Stages Hodgkin's Lymphoma

    NCT00147875 · start 2004-03

    Registered record
    Registry ID
    NCT00147875
    Conditions
    Hodgkin's Disease
    Interventions
    Prednisone; Vinblastine; Doxorubicin (Adriamycin); Gemcitabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2004-03
    Completion
    Not recorded
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHodgkin's Disease
    InterventionPrednisone; Vinblastine; Doxorubicin (Adriamycin); Gemcitabine
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer

    NCT00024167 · start 2002-04

    Registered record
    Registry ID
    NCT00024167
    Conditions
    Prostate Cancer
    Interventions
    Docetaxel; Doxorubicin hydrochloride; Estramustine phosphate sodium; Ketoconazole; Prednisone; Vinblastine; Strontium chloride Sr 89; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2002-04
    Completion
    Not recorded
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDocetaxel; Doxorubicin hydrochloride; Estramustine phosphate sodium; Ketoconazole +4 more
    PhasePhase 3
    Registry statusTerminated

  • Phase 2 Study of Vinblastine in Children With Recurrent or Refractory Low Grade Glioma

    NCT00213278 · start 2002-01

    Registered record
    Registry ID
    NCT00213278
    Conditions
    Glioma
    Interventions
    vinblastine sulphate injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2002-01
    Completion
    2012-09
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioma
    Interventionvinblastine sulphate injection
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy +/- Radiation in High Risk Hodgkin's Disease

    NCT00225173 · start 2001-10

    Registered record
    Registry ID
    NCT00225173
    Conditions
    Hodgkin Disease
    Interventions
    Doxorubicin; Vinblastine; Cyclophosphamide; Etoposide; Vincristine; Bleomycin; Gemcitabine; Vinorelbine; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2001-10
    Completion
    2006-09
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHodgkin Disease
    InterventionDoxorubicin; Vinblastine; Cyclophosphamide; Etoposide +5 more
    PhasePhase 2
    Registry statusTerminated

  • Rituximab and ABVD for Hodgkin's Patients

    NCT00504504 · start 2001-03

    Registered record
    Registry ID
    NCT00504504
    Conditions
    Lymphoma
    Interventions
    Rituximab; Adriamycin; Bleomycin; Vinblastine; Dacarbazine (DTIC)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2001-03
    Completion
    2012-03
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    InterventionRituximab; Adriamycin; Bleomycin; Vinblastine +1 more
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy in Treating Patients With Transitional Cell Cancer of the Urothelium

    NCT00014274 · start 2001-01

    Registered record
    Registry ID
    NCT00014274
    Conditions
    Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
    Interventions
    carboplatin; gemcitabine hydrochloride; methotrexate; vinblastine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2001-01
    Completion
    Not recorded
    Enrolment
    238

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
    Interventioncarboplatin; gemcitabine hydrochloride; methotrexate; vinblastine sulfate
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • S9901 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Men With Stage III or Stage IV Hodgkin's Disease

    NCT00005090 · start 2000-04

    Registered record
    Registry ID
    NCT00005090
    Conditions
    Lymphoma
    Interventions
    bleomycin sulfate; carmustine; cyclophosphamide; dacarbazine; doxorubicin hydrochloride; etoposide; vinblastine; peripheral blood stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2000-04
    Completion
    2005-05
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionbleomycin sulfate; carmustine; cyclophosphamide; dacarbazine +4 more
    PhasePhase 3
    Registry statusTerminated

  • Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

    NCT00025064 · start 2000-01

    Registered record
    Registry ID
    NCT00025064
    Conditions
    Lymphoma
    Interventions
    bleomycin sulfate; chlorambucil; cisplatin; dacarbazine; doxorubicin hydrochloride; etoposide; ifosfamide; melphalan; prednisolone; procarbazine hydrochloride; vinblastine sulfate; vincristine sulfate; peripheral blood stem cell transplantation; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2000-01
    Completion
    Not recorded
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionbleomycin sulfate; chlorambucil; cisplatin; dacarbazine +10 more
    PhasePhase 2
    Registry statusUnknown

  • Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

    NCT00003389 · start 1999-06-17

    Registered record
    Registry ID
    NCT00003389
    Conditions
    Lymphoma
    Interventions
    Doxorubicin; Bleomycin; Vinblastine; Dacarbazine; Vincristine; Mechlorethamine; Etoposide; Prednisone; Cyclophosphamide; Radiotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1999-06-17
    Completion
    2016-05
    Enrolment
    854

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    InterventionDoxorubicin; Bleomycin; Vinblastine; Dacarbazine +6 more
    PhasePhase 3
    Registry statusCompleted

  • Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

    NCT00005584 · start 1998-10

    Registered record
    Registry ID
    NCT00005584
    Conditions
    Lymphoma
    Interventions
    bleomycin sulfate; ABVD regimen; BEACOPP regimen; epirubicin hydrochloride; prednisone; vinblastine sulfate; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    1998-10
    Completion
    Not recorded
    Enrolment
    1,649

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionbleomycin sulfate; ABVD regimen; BEACOPP regimen; epirubicin hydrochloride +3 more
    PhasePhase 3
    Registry statusActive not recruiting

  • Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

    NCT00004209 · start 1998-05

    Registered record
    Registry ID
    NCT00004209
    Conditions
    Lung Cancer
    Interventions
    cisplatin; mitomycin C; vinblastine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    1998-05
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer
    Interventioncisplatin; mitomycin C; vinblastine sulfate
    PhasePhase 3
    Registry statusUnknown

  • Combination Chemotherapy in Treating Patients With Stage II Bladder Cancer

    NCT00002919 · start 1996-11

    Registered record
    Registry ID
    NCT00002919
    Conditions
    Bladder Cancer
    Interventions
    filgrastim; cisplatin; doxorubicin hydrochloride; methotrexate; vinblastine sulfate; conventional surgery
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1996-11
    Completion
    2003-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Cancer
    Interventionfilgrastim; cisplatin; doxorubicin hydrochloride; methotrexate +2 more
    PhasePhase 2
    Registry statusCompleted

  • Study of a-Interferon With Adriamycin, Bleomycin, Velban, and Dacarbazine (ABVD) With Hodgkin's Disease

    NCT01404936 · start 1996-07

    Registered record
    Registry ID
    NCT01404936
    Conditions
    Lymphoma
    Interventions
    Interferon-2A; Adriamycin; Bleomycin; Velban; Dacarbazine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1996-07
    Completion
    2011-12
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    InterventionInterferon-2A; Adriamycin; Bleomycin; Velban +1 more
    PhasePhase 2
    Registry statusCompleted