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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocortisone

FDA-approved product (tablet, oral), marketed as Acticort, Aeroseb-Hc, Ala-Cort and 34 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Hydrocortisone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Adrenal gland disease
  • Adrenocortical insufficiency
  • Allergic conjunctivitis
  • Asthma
  • Atopic eczema
  • Bursitis
  • Cancer
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Crohn's disease
  • Dermatitis
  • Endocrine system disease
  • Exanthem
  • Eye inflammation
  • Hemorrhoid
  • Herpes Labialis
  • and 19 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, weak, other combinations
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocortisone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocortisone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness

    NCT06311188 · start 2026-09-18

    Registered record
    Registry ID
    NCT06311188
    Conditions
    Stress; Trauma; PTSD; HPA
    Interventions
    ITR Healing intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09-18
    Completion
    2027-01-31
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStress; Trauma; PTSD; HPA
    InterventionITR Healing intervention
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Hard and Soft Tissue Outcomes of Vestibular Socket Therapy Using Magnesium Membrane Versus Cortical Lamina in the Esthetic Zone.

    NCT07800377 · start 2026-09

    Registered record
    Registry ID
    NCT07800377
    Conditions
    Type II Extraction Sockets in the Esthetic Zone
    Interventions
    Vestibular Socket Therapy Using Magnesium Membrane; Vestibular Socket Therapy Using Cortical Lamina
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09
    Completion
    2027-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType II Extraction Sockets in the Esthetic Zone
    InterventionVestibular Socket Therapy Using Magnesium Membrane; Vestibular Socket Therapy Using Cortical Lamina
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Cortisol and Obesity - A Vicious Cycle? Hypoglycemia After Bariatric Surgery - Association With Cortisol Metabolism?

    NCT06896682 · start 2025-07-08

    Registered record
    Registry ID
    NCT06896682
    Conditions
    Postbariatric Hypoglycemia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2025-07-08
    Completion
    2026-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostbariatric Hypoglycemia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusRecruiting

  • Virtual Reality to Reduce Intraoperative Anxiety in Vasectomies Under Local Anesthesia

    NCT06749353 · start 2025-01

    Registered record
    Registry ID
    NCT06749353
    Conditions
    Anxiety
    Interventions
    Virtual reality
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-01
    Completion
    2026-12
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety
    InterventionVirtual reality
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Venous Congestion And Delirium After Cardiac Surgery

    NCT07285187 · start 2024-11-01

    Registered record
    Registry ID
    NCT07285187
    Conditions
    Intraoperative; Venous Congestion; Postoperative Delirium (POD); Cardiac Surgery
    Interventions
    collection of demographic characteristics and comorbidities; surgery-related parameters; POD assessments; collection of biological (laboratory) parameters; collection of hemodynamic parameters; collection of echocardiographic parameters and venous ultrasound assessments; collection of parameters monitoring on the central nervous system
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-11-01
    Completion
    2026-10-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntraoperative; Venous Congestion; Postoperative Delirium (POD); Cardiac Surgery
    Interventioncollection of demographic characteristics and comorbidities; surgery-related parameters; POD assessments; collection of biological (laboratory) parameters +3 more
    PhaseNot recorded
    Registry statusRecruiting

  • Hair Cortisol as Marker of Chronic Stress in Preterm and Term Fathers - Fathair-study

    NCT05969431 · start 2024-10-01

    Registered record
    Registry ID
    NCT05969431
    Conditions
    Stress, Psychological; Father-Child Relations; Premature Birth
    Interventions
    measurement of cortisol level
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-10-01
    Completion
    2025-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStress, Psychological; Father-Child Relations; Premature Birth
    Interventionmeasurement of cortisol level
    PhaseNot recorded
    Registry statusRecruiting

  • Athlete Biochemical Monitoring and Nutritional Support

    NCT06553963 · start 2024-08-20

    Registered record
    Registry ID
    NCT06553963
    Conditions
    Weight Reduction
    Interventions
    Control group; Experimental group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-08-20
    Completion
    2024-09-20
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWeight Reduction
    InterventionControl group; Experimental group
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Music on Pain, Anxiety, and Behavior in Anxious Children During Molar Restorations

    NCT07144579 · start 2024-08-01

    Registered record
    Registry ID
    NCT07144579
    Conditions
    Healhty
    Interventions
    Mozart music group; preferred music group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-08-01
    Completion
    2025-08-01
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealhty
    InterventionMozart music group; preferred music group
    PhaseNot applicable
    Registry statusCompleted

  • Psychosocial Effects of Coloring in Preeclamptic Pregnant Women

    NCT06925841 · start 2024-03-29

    Registered record
    Registry ID
    NCT06925841
    Conditions
    Preeclampsia; Anxiety; Pregnancy; Stress
    Interventions
    Experimental; routine care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-03-29
    Completion
    2024-12-15
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreeclampsia; Anxiety; Pregnancy; Stress
    InterventionExperimental; routine care
    PhaseNot applicable
    Registry statusCompleted

  • Motivational Interviewing Inadequate Milk and Cortisol

    NCT06344663 · start 2024-03-25

    Registered record
    Registry ID
    NCT06344663
    Conditions
    Motivation
    Interventions
    motivational interview
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-03-25
    Completion
    2024-12-25
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMotivation
    Interventionmotivational interview
    PhaseNot recorded
    Registry statusUnknown

  • Stress Reactivity and Hormonal Contraception

    NCT06223126 · start 2024-01-22

    Registered record
    Registry ID
    NCT06223126
    Conditions
    Hormonal Contraception
    Interventions
    Combined oral contraception; Discontinuation of a combined oral contraception
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-01-22
    Completion
    2025-12
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHormonal Contraception
    InterventionCombined oral contraception; Discontinuation of a combined oral contraception
    PhaseNot recorded
    Registry statusUnknown

  • Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

    NCT06136624 · start 2023-12-31

    Registered record
    Registry ID
    NCT06136624
    Conditions
    Prostate Cancer Metastatic
    Interventions
    Opevesostat; Abiraterone acetate; Enzalutamide; Hydrocortisone; Fludrocortisone acetate; Prednisone; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2023-12-31
    Completion
    2030-02-15
    Enrolment
    1,310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer Metastatic
    InterventionOpevesostat; Abiraterone acetate; Enzalutamide; Hydrocortisone +3 more
    PhasePhase 3
    Registry statusRecruiting

  • Vertical Soft Tissue Augmentation With CTG vs ADM

    NCT05729607 · start 2023-05-26

    Registered record
    Registry ID
    NCT05729607
    Conditions
    Implant Complication
    Interventions
    Vertical soft tissue augmentation; Vertical soft tissue augmentation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-05-26
    Completion
    2027-11-27
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImplant Complication
    InterventionVertical soft tissue augmentation; Vertical soft tissue augmentation
    PhaseNot applicable
    Registry statusRecruiting

  • The Association Between Food Timing and Composition on Gastrointestinal Injury, Stress Hormone and Gastrointestinal Complains.

    NCT06403241 · start 2023-05-01

    Registered record
    Registry ID
    NCT06403241
    Conditions
    Endothelial Dysfunction
    Interventions
    2000 meter ergometer test
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-05-01
    Completion
    2023-06-30
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndothelial Dysfunction
    Intervention2000 meter ergometer test
    PhaseNot recorded
    Registry statusCompleted

  • Clinical and Metabolic, Immunological and Microbiological Characteristics of Obese Patients

    NCT05920785 · start 2023-04-02

    Registered record
    Registry ID
    NCT05920785
    Conditions
    Obesity
    Interventions
    Determination of the level of interleukins in the blood, stool analysis for the intestinal microbiome, general clinical tests, glucose tolerance test, hormonal profile
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2023-04-02
    Completion
    2026-04-02
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionDetermination of the level of interleukins in the blood, stool analysis for the intestinal microbiome, general clinical tests, glucose tolerance test, hormonal profile
    PhaseNot recorded
    Registry statusActive not recruiting