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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocortisone

FDA-approved product (tablet, oral), marketed as Acticort, Aeroseb-Hc, Ala-Cort and 34 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Hydrocortisone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Adrenal gland disease
  • Adrenocortical insufficiency
  • Allergic conjunctivitis
  • Asthma
  • Atopic eczema
  • Bursitis
  • Cancer
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Crohn's disease
  • Dermatitis
  • Endocrine system disease
  • Exanthem
  • Eye inflammation
  • Hemorrhoid
  • Herpes Labialis
  • and 19 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, weak, other combinations
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocortisone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocortisone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Characterization of priMary And sEcondary STress Related takOtsubo

    NCT05793008 · start 2023-03-30

    Registered record
    Registry ID
    NCT05793008
    Conditions
    Takotsubo Cardiomyopathy; Sepsis-induced Cardiomyopathy
    Interventions
    Positron Emission Tomography (PET) analysis; Blood samples collection; Clinical follow up visit
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-03-30
    Completion
    2026-09-02
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTakotsubo Cardiomyopathy; Sepsis-induced Cardiomyopathy
    InterventionPositron Emission Tomography (PET) analysis; Blood samples collection; Clinical follow up visit
    PhaseNot applicable
    Registry statusUnknown

  • Recovery Strategies Based on Mindfulness and Physical Exercise on Levels of Stress and Inmunoglobulin A

    NCT05771649 · start 2023-03-06

    Registered record
    Registry ID
    NCT05771649
    Conditions
    Mental Health Wellness
    Interventions
    Mindfulness-based intervention; Physical exercise
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-06
    Completion
    2023-06-30
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMental Health Wellness
    InterventionMindfulness-based intervention; Physical exercise
    PhaseNot applicable
    Registry statusCompleted

  • Xanamem® in Adults With Major Depressive Disorder and Impaired Cognition (XanaCIDD)

    NCT05657691 · start 2022-11-28

    Registered record
    Registry ID
    NCT05657691
    Conditions
    Major Depressive Disorder; MDD; Cognitive Impairment
    Interventions
    Xanamem™; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2022-11-28
    Completion
    2024-07-01
    Enrolment
    167

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; MDD; Cognitive Impairment
    InterventionXanamem™; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effects of Metyrapone in Patients With Hypercortisolism

    NCT05255900 · start 2022-04-28

    Registered record
    Registry ID
    NCT05255900
    Conditions
    Hypercortisolism
    Interventions
    Metyrapone Capsules
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-04-28
    Completion
    2025-12-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercortisolism
    InterventionMetyrapone Capsules
    PhaseNot recorded
    Registry statusCompleted

  • Long-term Safety Study of Chronocort in the Treatment of Participants With Congenital Adrenal Hyperplasia

    NCT05299554 · start 2022-04-01

    Registered record
    Registry ID
    NCT05299554
    Conditions
    Congenital Adrenal Hyperplasia
    Interventions
    Chronocort
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2022-04-01
    Completion
    2026-01-15
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Adrenal Hyperplasia
    InterventionChronocort
    PhasePhase 3
    Registry statusCompleted

  • A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

    NCT04501614 · start 2021-02-24

    Registered record
    Registry ID
    NCT04501614
    Conditions
    Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL); Ph+ Mixed Phenotype Acute Leukemia (MPAL); Philadelphia Chromosome-Like ALL (Ph-like ALL)
    Interventions
    Ponatinib; Chemotherapy Agents
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2021-02-24
    Completion
    2024-07-19
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL); Ph+ Mixed Phenotype Acute Leukemia (MPAL); Philadelphia Chromosome-Like ALL (Ph-like ALL)
    InterventionPonatinib; Chemotherapy Agents
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)

    NCT04373265 · start 2020-09-30

    Registered record
    Registry ID
    NCT04373265
    Conditions
    Adrenocortical Carcinoma
    Interventions
    Relacorilant; Pembrolizumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-09-30
    Completion
    2024-01-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdrenocortical Carcinoma
    InterventionRelacorilant; Pembrolizumab
    PhasePhase 1
    Registry statusCompleted

  • Symptoms and Mechanisms of Child Psychiatric Disorders

    NCT05049356 · start 2019-09-01

    Registered record
    Registry ID
    NCT05049356
    Conditions
    Disruptive Mood Dysregulation Disorder; Attention Deficit Hyperactivity Disorder; Oppositional Defiant Disorder; Severe Irritability; Child Psychiatric Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-09-01
    Completion
    2023-12
    Enrolment
    218

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDisruptive Mood Dysregulation Disorder; Attention Deficit Hyperactivity Disorder; Oppositional Defiant Disorder; Severe Irritability +1 more
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase

    NCT03702010 · start 2018-11-20

    Registered record
    Registry ID
    NCT03702010
    Conditions
    Laminectomy; Post-laminectomy Syndrome; Spinal Cord Syndrome; Failed Back Surgery Syndrome
    Interventions
    spinal cord stimulation conventional; spinal cord stimulation experimental
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-11-20
    Completion
    2020-07-01
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaminectomy; Post-laminectomy Syndrome; Spinal Cord Syndrome; Failed Back Surgery Syndrome
    Interventionspinal cord stimulation conventional; spinal cord stimulation experimental
    PhaseNot applicable
    Registry statusCompleted

  • Open-label Comparison of Chronocort® Versus Standard Glucocorticoid Replacement Therapy

    NCT03532022 · start 2018-10-04

    Registered record
    Registry ID
    NCT03532022
    Conditions
    Congenital Adrenal Hyperplasia
    Interventions
    Chronocort®; Standard Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2018-10-04
    Completion
    2021-07-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Adrenal Hyperplasia
    InterventionChronocort®; Standard Care
    PhasePhase 3
    Registry statusWithdrawn

  • Stress Hormones and IUDs

    NCT03499379 · start 2018-04-16

    Registered record
    Registry ID
    NCT03499379
    Conditions
    Contraception; Mood Change
    Interventions
    Mirena; Paraguard
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-04-16
    Completion
    2019-12-31
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception; Mood Change
    InterventionMirena; Paraguard
    PhaseNot recorded
    Registry statusCompleted

  • Re-nutrition in Severe Anorexia Nervosa

    NCT02502617 · start 2016-03-01

    Registered record
    Registry ID
    NCT02502617
    Conditions
    Anorexia Nervosa
    Interventions
    medical nutrition
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-03-01
    Completion
    2023-10
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnorexia Nervosa
    Interventionmedical nutrition
    PhaseNot recorded
    Registry statusCompleted

  • Effects of Bundled Supportive Interventions on Preterm Infants' Stress-Related Outcomes During Invasive Procedures

    NCT03010891 · start 2016-03

    Registered record
    Registry ID
    NCT03010891
    Conditions
    Preterm Infants; Stress
    Interventions
    The bundle of supportive interventions; Usual NICU care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-03
    Completion
    2018-05
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Infants; Stress
    InterventionThe bundle of supportive interventions; Usual NICU care
    PhaseNot applicable
    Registry statusCompleted

  • Evaluating the Efficacy of ABC for High-Risk Parent and Infants

    NCT02647463 · start 2016-01

    Registered record
    Registry ID
    NCT02647463
    Conditions
    Attachment Disorders
    Interventions
    Attachment and Biobehavioral Catch-up (ABC)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2018-10
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAttachment Disorders
    InterventionAttachment and Biobehavioral Catch-up (ABC)
    PhaseNot applicable
    Registry statusUnknown

  • A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma

    NCT01614197 · start 2015-07-03

    Registered record
    Registry ID
    NCT01614197
    Conditions
    Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Lymphoma; Peripheral T-cell Lymphoma
    Interventions
    Temsirolimus; Etoposide; Cyclophosphamide; Methotrexate; Hydrocortisone; Cytarabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-07-03
    Completion
    2020-09-04
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Lymphoma; Peripheral T-cell Lymphoma
    InterventionTemsirolimus; Etoposide; Cyclophosphamide; Methotrexate +2 more
    PhasePhase 1
    Registry statusCompleted