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AMR Drug RepurposingSmart Screeningresearch prototype

Thiamine Hydrochloride

FDA-approved product (injectable, injection), marketed as Betalin S, Thiamine Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Thiamine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Chronic kidney disease
  • Encephalopathy
  • Iron deficiency anemia
  • Thiamine deficiency

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin b1, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli50.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae20.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis34.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Thiamine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Thiamine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Trial On The Effect Of Artisterol On Risk Factors In Individuals With Suboptimal Cholesterol Levels

    NCT07405814 · start 2026-04-24

    Registered record
    Registry ID
    NCT07405814
    Conditions
    Hyperlipoproteinemia
    Interventions
    investigational product containing phytosterol, artichoke extract and thiamin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-04-24
    Completion
    2026-12-31
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperlipoproteinemia
    Interventioninvestigational product containing phytosterol, artichoke extract and thiamin; Placebo
    PhaseNot applicable
    Registry statusRecruiting

  • Human Albumin for Resuscitation in Surgical Septic Shock: A Randomized Controlled Trial (ALBUS Study)

    NCT07212582 · start 2025-12-01

    Registered record
    Registry ID
    NCT07212582
    Conditions
    Critical Illness; Septic Shock
    Interventions
    Human Albumin 20% Solution; Standard Care (in control arm)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-12-01
    Completion
    2030-12-31
    Enrolment
    304

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritical Illness; Septic Shock
    InterventionHuman Albumin 20% Solution; Standard Care (in control arm)
    PhasePhase 3
    Registry statusNot yet recruiting

  • Thiamine Intervention and Coronary Artery Bypass Grafting

    NCT06326996 · start 2024-10-10

    Registered record
    Registry ID
    NCT06326996
    Conditions
    Coronary Heart Disease; Coronary Artery Bypass Grafting
    Interventions
    Thiamine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Recruiting
    Start
    2024-10-10
    Completion
    2026-09-30
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease; Coronary Artery Bypass Grafting
    InterventionThiamine; Placebo
    PhaseEarly phase 1
    Registry statusRecruiting

  • Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain

    NCT06516094 · start 2024-04-11

    Registered record
    Registry ID
    NCT06516094
    Conditions
    Chronic Low-back Pain
    Interventions
    Celecoxib+Pregabalin+Vitamin B fixed dose; Celecoxib + Vitamin B fixed dose; Pregabalin + Vitamin B fixed dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2024-04-11
    Completion
    2025-01-07
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Low-back Pain
    InterventionCelecoxib+Pregabalin+Vitamin B fixed dose; Celecoxib + Vitamin B fixed dose; Pregabalin + Vitamin B fixed dose
    PhasePhase 3
    Registry statusCompleted

  • COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease

    NCT05873881 · start 2024-01-29

    Registered record
    Registry ID
    NCT05873881
    Conditions
    Heart Failure
    Interventions
    Colchicine 0.5 MG; Colchicine placebo; Thiamine Mononitrate 300 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-01-29
    Completion
    2027-06
    Enrolment
    2,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    InterventionColchicine 0.5 MG; Colchicine placebo; Thiamine Mononitrate 300 mg
    PhasePhase 3
    Registry statusRecruiting

  • Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.

    NCT06649825 · start 2024-01-08

    Registered record
    Registry ID
    NCT06649825
    Conditions
    Familial Adenomatous Polyposis (FAP)
    Interventions
    Vitamin B1
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2024-01-08
    Completion
    2028-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFamilial Adenomatous Polyposis (FAP)
    InterventionVitamin B1
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • the Effect of Vitamin B 1 on Menstrual Pattern After Insertion of the IUD.

    NCT05971680 · start 2023-07-30

    Registered record
    Registry ID
    NCT05971680
    Conditions
    Intra-uterine Device Complication
    Interventions
    VITAMIN B1 500mg; intra-uterine contraceptive device
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2023-07-30
    Completion
    2023-11-30
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra-uterine Device Complication
    InterventionVITAMIN B1 500mg; intra-uterine contraceptive device
    PhasePhase 3
    Registry statusUnknown

  • The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age

    NCT05682261 · start 2023-03-23

    Registered record
    Registry ID
    NCT05682261
    Conditions
    Anemia
    Interventions
    UNIMMAP-MMS; IFA; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-23
    Completion
    2023-10-17
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnemia
    InterventionUNIMMAP-MMS; IFA; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders

    NCT05390086 · start 2022-06-15

    Registered record
    Registry ID
    NCT05390086
    Conditions
    Thiamine Deficiency
    Interventions
    Standard of care
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-06-15
    Completion
    2022-08-26
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThiamine Deficiency
    InterventionStandard of care
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy.

    NCT05464498 · start 2022-06-13

    Registered record
    Registry ID
    NCT05464498
    Conditions
    Tendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    Interventions
    MD-Tissue Collagen Medical Device; eccentric strengthening protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-06-13
    Completion
    2026-11-01
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    InterventionMD-Tissue Collagen Medical Device; eccentric strengthening protocol
    PhaseNot applicable
    Registry statusRecruiting

  • Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors

    NCT04921189 · start 2021-12-31

    Registered record
    Registry ID
    NCT04921189
    Conditions
    Out-Of-Hospital Cardiac Arrest; Postcardiac Arrest Syndrome
    Interventions
    The combined supplement of Ascorbic acid, Thiamine, and Cortisol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-12-31
    Completion
    2025-06-09
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOut-Of-Hospital Cardiac Arrest; Postcardiac Arrest Syndrome
    InterventionThe combined supplement of Ascorbic acid, Thiamine, and Cortisol; Placebo
    PhasePhase 2
    Registry statusCompleted

  • B1 and Magnesium Supplements on Glucose Metabolism in Low-carb Dieters

    NCT04651205 · start 2021-10

    Registered record
    Registry ID
    NCT04651205
    Conditions
    Diet, Carbohydrate-restricted
    Interventions
    vitamin B1 and magnesium supplements
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Suspended
    Start
    2021-10
    Completion
    2022-10
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiet, Carbohydrate-restricted
    Interventionvitamin B1 and magnesium supplements
    PhaseNot applicable
    Registry statusSuspended

  • Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa

    NCT04999137 · start 2021-09-01

    Registered record
    Registry ID
    NCT04999137
    Conditions
    Sepsis; Septic Shock; HIV
    Interventions
    Vitamin C; Vitamin B1
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2021-09-01
    Completion
    2021-12-29
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Septic Shock; HIV
    InterventionVitamin C; Vitamin B1
    PhasePhase 2
    Registry statusUnknown

  • Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock

    NCT05192213 · start 2021-08-01

    Registered record
    Registry ID
    NCT05192213
    Conditions
    Sepsis; Septic Shock
    Interventions
    Vitamin C; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2021-08-01
    Completion
    2022-09-19
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Septic Shock
    InterventionVitamin C; Placebo
    PhasePhase 3
    Registry statusTerminated

  • Sumor as Adjuvant Therapy in Treatment-resistant Major Depression

    NCT04832178 · start 2021-06-01

    Registered record
    Registry ID
    NCT04832178
    Conditions
    Major Depressive Disorder
    Interventions
    SUMOR; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-06-01
    Completion
    2024-06-01
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionSUMOR; Placebo
    PhasePhase 4
    Registry statusUnknown