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AMR Drug RepurposingSmart Screeningresearch prototype

Clindamycin Hydrochloride

FDA-approved product (capsule, oral), marketed as Cleocin, Cleocin Hydrochloride, Clindamycin Hydrochloride.

Registered studies
50+
Lab records
4
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Clindamycin Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Bacterial disease
  • Endometritis
  • Infection
  • Osteomyelitis
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives for treatment of acne; Antibiotics; Lincosamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF01; WHO ATC J01FF01; WHO ATC G01AA10

Repurposing investigation

Clindamycin Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli13.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 0 of 4 lab records
Open Clindamycin Hydrochloride in ChEMBL Registered studies below
Show the 4 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clindamycin Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study CLBG and Benzoyl Peroxide Gel 1%/5% to BenzaClin® Gel in the Treatment of Acne Vulgaris

    NCT02595034 · start 2015-01

    Registered record
    Registry ID
    NCT02595034
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin and Benzoyl Peroxide Gel 1%5%; BenzaClin® Topical Gel; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-01
    Completion
    2015-11
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin and Benzoyl Peroxide Gel 1%5%; BenzaClin® Topical Gel; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy

    NCT02579161 · start 2014-09

    Registered record
    Registry ID
    NCT02579161
    Conditions
    Kidney Stones
    Interventions
    cephalosporins; Fluoroquinolones; Clindamycin; Ampicillin/Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-09
    Completion
    2018-12
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Stones
    Interventioncephalosporins; Fluoroquinolones; Clindamycin; Ampicillin/Gentamicin
    PhasePhase 3
    Registry statusCompleted

  • Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile

    NCT01744730 · start 2013-06

    Registered record
    Registry ID
    NCT01744730
    Conditions
    Bacterial Infections; Obesity
    Interventions
    Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-06
    Completion
    2014-08
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections; Obesity
    InterventionClindamycin
    PhasePhase 1
    Registry statusCompleted

  • Evaluate Therapeutic Equivalence and Safety of Two Clindamycin Phosphate and Benzoyl Peroxide Gels in Acne Vulgaris

    NCT01788384 · start 2012-07

    Registered record
    Registry ID
    NCT01788384
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin Phosphate / Benzoyl Peroxide Gel; Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Placebo (Vehicle Gel)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-07
    Completion
    2012-12
    Enrolment
    708

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin Phosphate / Benzoyl Peroxide Gel; Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Placebo (Vehicle Gel)
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria

    NCT01361269 · start 2011-06

    Registered record
    Registry ID
    NCT01361269
    Conditions
    Malaria
    Interventions
    Fosmidomycin and clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-06
    Completion
    2011-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionFosmidomycin and clindamycin
    PhasePhase 2
    Registry statusUnknown

  • Prevention of Arrhythmia Device Infection Trial (PADIT)

    NCT01613092 · start 2011-05

    Registered record
    Registry ID
    NCT01613092
    Conditions
    Arrhythmia
    Interventions
    Incremental; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2013-12
    Enrolment
    241

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    InterventionIncremental; Cefazolin
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated P.Falciparum Malaria in Children

    NCT01464138 · start 2010-09

    Registered record
    Registry ID
    NCT01464138
    Conditions
    Malaria
    Interventions
    Fosmidomycin and Clindamycin co-administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionFosmidomycin and Clindamycin co-administration
    PhasePhase 2
    Registry statusCompleted

  • Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa

    NCT01063270 · start 2010-02

    Registered record
    Registry ID
    NCT01063270
    Conditions
    Hidradenitis Suppurativa
    Interventions
    Clindamycin & Rifampin; Clindamycin + Rifampin along with NdYag Laser treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-02
    Completion
    2013-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHidradenitis Suppurativa
    InterventionClindamycin & Rifampin; Clindamycin + Rifampin along with NdYag Laser treatment
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess

    NCT01498744 · start 2010-02

    Registered record
    Registry ID
    NCT01498744
    Conditions
    Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    Interventions
    Oral Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2013-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    InterventionOral Clindamycin
    PhaseNot applicable
    Registry statusTerminated

  • A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne

    NCT00964223 · start 2009-07

    Registered record
    Registry ID
    NCT00964223
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-11
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    PhasePhase 4
    Registry statusCompleted

  • W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy Volunteers

    NCT01929278 · start 2008-12-08

    Registered record
    Registry ID
    NCT01929278
    Conditions
    Acne Vulgaris
    Interventions
    CT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12-08
    Completion
    2008-12-19
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionCT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    PhasePhase 1
    Registry statusCompleted

  • Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne

    NCT00776919 · start 2008-10

    Registered record
    Registry ID
    NCT00776919
    Conditions
    Acne Vulgaris
    Interventions
    clindamycin / benzoyl peroxide gel; clindamycin gel; BPO gel; vehicle gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-09
    Enrolment
    1,315

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    Interventionclindamycin / benzoyl peroxide gel; clindamycin gel; BPO gel; vehicle gel
    PhasePhase 3
    Registry statusCompleted

  • Vaginal Infection Study 2

    NCT00694928 · start 2008-05

    Registered record
    Registry ID
    NCT00694928
    Conditions
    Vaginal Infection
    Interventions
    clindamycin phosphate/butoconazole nitrate; butoconazole nitrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-05
    Completion
    2009-11
    Enrolment
    843

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginal Infection
    Interventionclindamycin phosphate/butoconazole nitrate; butoconazole nitrate
    PhasePhase 3
    Registry statusCompleted

  • The Role of Antibiotic Treatment in Patients With Acute Mild Cholecystitis - A Prospective Randomized Controlled Trial

    NCT00557453 · start 2008-04

    Registered record
    Registry ID
    NCT00557453
    Conditions
    Acute Cholecystitits
    Interventions
    Antibiotic treatment; No antibiotics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-04
    Completion
    2010-04
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Cholecystitits
    InterventionAntibiotic treatment; No antibiotics
    PhaseNot recorded
    Registry statusCompleted

  • A Study to Compare Efficacy and Safety of an Ovule Containing Terconazole, Clindamycin and Fluocinolone Versus an Ovule Containing Metronidazole, Nystatin and Fluocinolone in the Treatment of Secondary Vulvar/ or Vaginal Symptoms of Infectious Vaginitis/ and Infectious Vaginosis

    NCT01867164 · start 2007-12

    Registered record
    Registry ID
    NCT01867164
    Conditions
    Vaginitis; Infectious Vaginosis
    Interventions
    Gynoclin V; Vagitrol V
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-12
    Completion
    2008-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginitis; Infectious Vaginosis
    InterventionGynoclin V; Vagitrol V
    PhasePhase 3
    Registry statusCompleted