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AMR Drug RepurposingSmart Screeningresearch prototype

Topiramate

FDA-approved product (tablet, oral), marketed as Eprontia, Qudexy Xr, Topamax and 3 more.

Registered studies
50+
Lab records
2
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Topiramate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Epilepsy
  • Lennox-Gastaut syndrome
  • Migraine disorder
  • Seizure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antiepileptics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA32.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli25.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis77.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 2 of 2 lab records
Open Topiramate in ChEMBL Registered studies below
Show the 2 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Topiramate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Placebo Controled Clinical Trial Using Topiramate To Treat Posttraumatic Stress Disorder (PTSD) Patients.

    NCT00725920 · start 2007-01

    Registered record
    Registry ID
    NCT00725920
    Conditions
    Posttraumatic Stress Disorder
    Interventions
    Topiramate; placebo control group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2009-12
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPosttraumatic Stress Disorder
    InterventionTopiramate; placebo control group
    PhasePhase 4
    Registry statusCompleted

  • Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania

    NCT00393978 · start 2006-11

    Registered record
    Registry ID
    NCT00393978
    Conditions
    Bipolar Disorder; Cannabis-Related Disorder
    Interventions
    Quetiapine and placebo; Quetiapine and Topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-11
    Completion
    2014-03
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Cannabis-Related Disorder
    InterventionQuetiapine and placebo; Quetiapine and Topiramate
    PhasePhase 4
    Registry statusCompleted

  • An Efficacy and Tolerability Study of Topiramate in Participants With Migraine

    NCT01060111 · start 2006-07

    Registered record
    Registry ID
    NCT01060111
    Conditions
    Migraine
    Interventions
    Topiramate Standard; Topiramate Slow; Propranolol booster
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2008-07
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionTopiramate Standard; Topiramate Slow; Propranolol booster
    PhasePhase 4
    Registry statusCompleted

  • Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

    NCT00755716 · start 2006-04

    Registered record
    Registry ID
    NCT00755716
    Conditions
    Tobacco Dependence
    Interventions
    Placebo (sugar pill); Topiramate; Nicotine patch
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2013-08
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTobacco Dependence
    InterventionPlacebo (sugar pill); Topiramate; Nicotine patch
    PhasePhase 3
    Registry statusCompleted

  • New Medications to Treat Alcohol Dependence

    NCT00223639 · start 2005-09

    Registered record
    Registry ID
    NCT00223639
    Conditions
    Alcoholism
    Interventions
    Topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-09
    Completion
    2008-07
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism
    InterventionTopiramate
    PhasePhase 2
    Registry statusCompleted

  • A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine Attacks in Children

    NCT00210535 · start 2005-06

    Registered record
    Registry ID
    NCT00210535
    Conditions
    Migraine; Vascular Headaches
    Interventions
    Topiramate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-11
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine; Vascular Headaches
    InterventionTopiramate; Placebo
    PhasePhase 3
    Registry statusCompleted

  • A Pilot Study of Topiramate in Childhood Absence Epilepsy

    NCT00210574 · start 2005-03

    Registered record
    Registry ID
    NCT00210574
    Conditions
    Epilepsy, Absence
    Interventions
    topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-03
    Completion
    2006-10
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy, Absence
    Interventiontopiramate
    PhasePhase 2
    Registry statusCompleted

  • An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine

    NCT00297336 · start 2005-03

    Registered record
    Registry ID
    NCT00297336
    Conditions
    Migraine Disorders
    Interventions
    Topiramate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-03
    Completion
    2007-02
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Disorders
    InterventionTopiramate
    PhaseNot recorded
    Registry statusCompleted

  • A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment

    NCT00210782 · start 2004-06

    Registered record
    Registry ID
    NCT00210782
    Conditions
    Epilepsy
    Interventions
    topiramate, phenytoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-06
    Completion
    2007-08
    Enrolment
    262

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    Interventiontopiramate, phenytoin
    PhasePhase 3
    Registry statusCompleted

  • An Open Label Extension of a Study of Topiramate in Chronic Migraine.

    NCT00210873 · start 2004-02

    Registered record
    Registry ID
    NCT00210873
    Conditions
    Migraine
    Interventions
    topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-02
    Completion
    2005-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    Interventiontopiramate
    PhasePhase 3
    Registry statusCompleted

  • A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately

    NCT00752466 · start 2003-03

    Registered record
    Registry ID
    NCT00752466
    Conditions
    Human Volunteers; Migraine
    Interventions
    Topiramate; flunarizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-03
    Completion
    2004-03
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHuman Volunteers; Migraine
    InterventionTopiramate; flunarizine
    PhasePhase 1
    Registry statusCompleted

  • Topiramate 25 mg Capsules Under Fed Conditions

    NCT00904943 · start 2002-06

    Registered record
    Registry ID
    NCT00904943
    Conditions
    Healthy
    Interventions
    Topiramate Capsules, 25 mg; Topamax® Capsules, 25 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2002-06
    Completion
    2002-07
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTopiramate Capsules, 25 mg; Topamax® Capsules, 25 mg
    PhasePhase 1
    Registry statusCompleted

  • Topiramate 25 mg Capsules Under Fasting Conditions

    NCT00905164 · start 2002-06

    Registered record
    Registry ID
    NCT00905164
    Conditions
    Healthy
    Interventions
    Topiramate Capsules, 25 mg; Topamax® Capsules, 25 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2002-06
    Completion
    2002-06
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTopiramate Capsules, 25 mg; Topamax® Capsules, 25 mg
    PhasePhase 1
    Registry statusCompleted

  • Topiramate Versus Placebo as add-on Treatment in Patients With Bipolar Disorder in the Outpatient Setting

    NCT00237289 · start 2001-10

    Registered record
    Registry ID
    NCT00237289
    Conditions
    Bipolar Disorder
    Interventions
    topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-10
    Completion
    2003-10
    Enrolment
    287

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    Interventiontopiramate
    PhasePhase 3
    Registry statusCompleted

  • Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)

    NCT00203463 · start 2001-07

    Registered record
    Registry ID
    NCT00203463
    Conditions
    PTSD
    Interventions
    topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2001-07
    Completion
    2004-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPTSD
    Interventiontopiramate
    PhasePhase 4
    Registry statusCompleted