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AMR Drug RepurposingSmart Screeningresearch prototype

Topiramate

FDA-approved product (tablet, oral), marketed as Eprontia, Qudexy Xr, Topamax and 3 more.

Registered studies
50+
Lab records
2
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Topiramate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Epilepsy
  • Lennox-Gastaut syndrome
  • Migraine disorder
  • Seizure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antiepileptics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA32.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli25.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis77.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 2 of 2 lab records
Open Topiramate in ChEMBL Registered studies below
Show the 2 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Topiramate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Qsymia as an Adjunct to Surgical Therapy in the Superobese

    NCT02301416 · start 2014-12

    Registered record
    Registry ID
    NCT02301416
    Conditions
    Obesity; Metabolic Surgery; Weight Loss; Bariatric Surgery Procedures
    Interventions
    Phentermine/topiramate; low calorie diet
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-12
    Completion
    2018-06-27
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Metabolic Surgery; Weight Loss; Bariatric Surgery Procedures
    InterventionPhentermine/topiramate; low calorie diet
    PhasePhase 2
    Registry statusCompleted

  • Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

    NCT01950520 · start 2014-02-07

    Registered record
    Registry ID
    NCT01950520
    Conditions
    Healthy Volunteers
    Interventions
    Propranolol; Pindolol; Dantrolene; Magnesium Sulfate; Caffeine; Qsymia; Topiramate; Phentermine; Naltrexone; Mirabegron 50mg; Mirabegron 200mg; Placebo Cohort 1; Placebo Cohort 2; Placebo for Mirabegron
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-02-07
    Completion
    2024-06-11
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionPropranolol; Pindolol; Dantrolene; Magnesium Sulfate +10 more
    PhasePhase 2
    Registry statusCompleted

  • Switchability Study Between Brand and Generic Topiramate

    NCT02113787 · start 2014-02

    Registered record
    Registry ID
    NCT02113787
    Conditions
    Epilepsy
    Interventions
    Pharmacokinetic study
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-02
    Completion
    2017-05
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionPharmacokinetic study
    PhaseNot applicable
    Registry statusCompleted

  • Topiramate to Reduce Heavy Drinking in HIV-Positive Heavy Drinkers

    NCT01764685 · start 2013-01

    Registered record
    Registry ID
    NCT01764685
    Conditions
    Heavy Drinking; HIV; Alcohol Dependence
    Interventions
    Topiramate; Medical Management; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-01
    Completion
    2014-01
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeavy Drinking; HIV; Alcohol Dependence
    InterventionTopiramate; Medical Management; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI

    NCT01750268 · start 2012-11

    Registered record
    Registry ID
    NCT01750268
    Conditions
    Traumatic Brain Injury (TBI); Hazardous and Harmful Alcohol Use
    Interventions
    Medical Management Counseling; Topiramate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-11
    Completion
    2015-10
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTraumatic Brain Injury (TBI); Hazardous and Harmful Alcohol Use
    InterventionMedical Management Counseling; Topiramate; Placebo
    PhasePhase 4
    Registry statusCompleted

  • A Study to Evaluate the Tolerability of Botox and Topiramate or Botox and Placebo and Effect on Cognitive Efficiency

    NCT01700387 · start 2012-10

    Registered record
    Registry ID
    NCT01700387
    Conditions
    Chronic Migraine
    Interventions
    onabotulinumtoxinA; Topiramate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Migraine
    InterventiononabotulinumtoxinA; Topiramate; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder

    NCT00571246 · start 2012-06

    Registered record
    Registry ID
    NCT00571246
    Conditions
    Alcohol Dependence; Post Traumatic Stress Disorder
    Interventions
    Topiramate; lamotrigine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2012-06
    Completion
    2016-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Dependence; Post Traumatic Stress Disorder
    InterventionTopiramate; lamotrigine; Placebo
    PhasePhase 3
    Registry statusWithdrawn

  • Flunarizine Versus Topiramate for Chronic Migraine Prophylaxis

    NCT02639598 · start 2012-06

    Registered record
    Registry ID
    NCT02639598
    Conditions
    Chronic Migraine
    Interventions
    Flunarizine; Topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-06
    Completion
    2015-03
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Migraine
    InterventionFlunarizine; Topiramate
    PhasePhase 4
    Registry statusCompleted

  • Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

    NCT00862563 · start 2009-05

    Registered record
    Registry ID
    NCT00862563
    Conditions
    Alcoholism; Alcohol Dependence; Alcohol Abuse
    Interventions
    Topiramate; Zonisamide; Levetiracetam; Sugar Pill
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-05
    Completion
    2013-08
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism; Alcohol Dependence; Alcohol Abuse
    InterventionTopiramate; Zonisamide; Levetiracetam; Sugar Pill
    PhasePhase 2
    Registry statusTerminated

  • A Study to Evaluate the Pharmacokinetics of VI-0521 Subjects With Renal Impairment

    NCT00768404 · start 2008-10

    Registered record
    Registry ID
    NCT00768404
    Conditions
    Renal Impairment
    Interventions
    Topirmate and Phentermine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-07
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Impairment
    InterventionTopirmate and Phentermine
    PhasePhase 1
    Registry statusCompleted

  • Open-Label Study to Evaluate the Long-Term Safety and Efficacy of VI-0521 in Type 2 Diabetic Adults

    NCT00737633 · start 2008-08

    Registered record
    Registry ID
    NCT00737633
    Conditions
    Diabetes
    Interventions
    VI-0521
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2008-08
    Completion
    2009-06
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes
    InterventionVI-0521
    PhasePhase 2
    Registry statusTerminated

  • Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.

    NCT00563459 · start 2007-11

    Registered record
    Registry ID
    NCT00563459
    Conditions
    Epilepsy; Seizures
    Interventions
    carisbamate; topiramate; levetiracetam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2007-11
    Completion
    2010-04
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy; Seizures
    Interventioncarisbamate; topiramate; levetiracetam
    PhasePhase 3
    Registry statusTerminated

  • Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults

    NCT00518466 · start 2007-07

    Registered record
    Registry ID
    NCT00518466
    Conditions
    Obesity
    Interventions
    topiramate; phentermine; topiramate; phentermine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-07
    Completion
    2007-12
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    Interventiontopiramate; phentermine; topiramate; phentermine
    PhasePhase 1
    Registry statusCompleted

  • Topiramate to Reduce Cocaine Dependence

    NCT00223626 · start 2007-01

    Registered record
    Registry ID
    NCT00223626
    Conditions
    Cocaine-Related Disorders
    Interventions
    Topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2010-12
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders
    InterventionTopiramate
    PhasePhase 2
    Registry statusCompleted

  • Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

    NCT00404248 · start 2007-01

    Registered record
    Registry ID
    NCT00404248
    Conditions
    Brain and Central Nervous System Tumors
    Interventions
    terameprocol; pharmacological study
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2012-02
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain and Central Nervous System Tumors
    Interventionterameprocol; pharmacological study
    PhasePhase 1 / Phase 2
    Registry statusCompleted