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AMR Drug RepurposingSmart Screeningresearch prototype

Lithium Citrate

FDA-approved product (syrup, oral), marketed as Lithium Citrate, Lithonate, Potassium Citrate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Lithium Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Bipolar I disorder
  • Major depressive disorder
  • Renal tubular acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Potassium; Salt solutions
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Lithium Citrate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lithium Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lithium Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer

    NCT00251316 · start 2005-11

    Registered record
    Registry ID
    NCT00251316
    Conditions
    Thyroid Cancer; Differentiated Thyroid Carcinoma
    Interventions
    Lithium Carbonate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-11
    Completion
    2011-12
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Cancer; Differentiated Thyroid Carcinoma
    InterventionLithium Carbonate; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Treatment of Mania Symptoms With Drug Therapy

    NCT00183443 · start 2005-02

    Registered record
    Registry ID
    NCT00183443
    Conditions
    Bipolar Disorder; Schizophrenia
    Interventions
    Divalproex-extended release (DVP-ER); Lithium; Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-02
    Completion
    2010-11
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Schizophrenia
    InterventionDivalproex-extended release (DVP-ER); Lithium; Quetiapine
    PhasePhase 3
    Registry statusCompleted

  • Olanzapine Versus Comparator in the Treatment of Bipolar Disorder

    NCT00485680 · start 2003-12

    Registered record
    Registry ID
    NCT00485680
    Conditions
    Bipolar Disorder
    Interventions
    Olanzapine Hydrochloride; Lithium Carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-12
    Completion
    2005-06
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionOlanzapine Hydrochloride; Lithium Carbonate
    PhasePhase 3
    Registry statusCompleted

  • Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode

    NCT01977300 · start 2003-01

    Registered record
    Registry ID
    NCT01977300
    Conditions
    Bipolar I Disorder
    Interventions
    Valproate; Lithium; Risperidone; Olanzapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-01
    Completion
    2011-08
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionValproate; Lithium; Risperidone; Olanzapine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalency Study of 450 mg Lithium Carbonate Under Fed Conditions

    NCT00601575 · start 2002-10

    Registered record
    Registry ID
    NCT00601575
    Conditions
    Bipolar Disorder
    Interventions
    Lithium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2002-10
    Completion
    2002-11
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionLithium
    PhaseNot applicable
    Registry statusCompleted