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AMR Drug RepurposingSmart Screeningresearch prototype

Lithium Citrate

FDA-approved product (syrup, oral), marketed as Lithium Citrate, Lithonate, Potassium Citrate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Lithium Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Bipolar I disorder
  • Major depressive disorder
  • Renal tubular acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Potassium; Salt solutions
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Lithium Citrate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lithium Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lithium Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Behavior and Patient Satisfaction of Zirconia-reinforced Glass-ceramic Crowns and Ultra-translucent-multilayered Monolithic Zirconia Crowns With a Conservative Marginal Design

    NCT07521501 · start 2026-06-01

    Registered record
    Registry ID
    NCT07521501
    Conditions
    Clinical Behavior of ZLS and UTML
    Interventions
    UTML (KATANA) crowns with conservative marginal design; ZLS (AMBRIA) crowns with conservative marginal design
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-06-01
    Completion
    2027-07-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClinical Behavior of ZLS and UTML
    InterventionUTML (KATANA) crowns with conservative marginal design; ZLS (AMBRIA) crowns with conservative marginal design
    PhaseNot applicable
    Registry statusNot yet recruiting

  • BioHPP and Lithium Disilicate Onlay Restorations: Clinical Evaluation

    NCT07142031 · start 2025-09-15

    Registered record
    Registry ID
    NCT07142031
    Conditions
    Dental Caries; Polymers
    Interventions
    BioHPP; Lithium Disilicate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2025-09-15
    Completion
    2026-10-15
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Caries; Polymers
    InterventionBioHPP; Lithium Disilicate
    PhaseNot applicable
    Registry statusActive not recruiting

  • A Study Evaluating 24 Months of Lithium Carbonate Treatment in Patients With TBR1-related Neurocognitive Disorder

    NCT06776848 · start 2025-09-12

    Registered record
    Registry ID
    NCT06776848
    Conditions
    Proven Pathogenic or Probably Pathogenic TBR1 Variant
    Interventions
    Observation phase; Lithium treatment; biological monitoring
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Recruiting
    Start
    2025-09-12
    Completion
    2027-09-12
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProven Pathogenic or Probably Pathogenic TBR1 Variant
    InterventionObservation phase; Lithium treatment; biological monitoring
    PhasePhase 1 / Phase 2
    Registry statusRecruiting

  • Development and Application of Precision Treatment Strategies for Common Mental Disorders

    NCT06729541 · start 2024-11-11

    Registered record
    Registry ID
    NCT06729541
    Conditions
    Depression - Major Depressive Disorder; Schizophrenia Disorders; Bipolar Disorder (BD)
    Interventions
    Multigenetic Pharmacogenomics-Guided Treatment (MPGT)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-11-11
    Completion
    2026-12
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression - Major Depressive Disorder; Schizophrenia Disorders; Bipolar Disorder (BD)
    InterventionMultigenetic Pharmacogenomics-Guided Treatment (MPGT)
    PhaseNot applicable
    Registry statusRecruiting

  • Bioequivalence Study of Lithium Carbonate 300 mg Tablets. Actilitio® in Healthy Subjects

    NCT06861842 · start 2024-06-01

    Registered record
    Registry ID
    NCT06861842
    Conditions
    Healthy; Healthy Donors
    Interventions
    Theralite®; Actilitio®
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2024-06-01
    Completion
    2025-04-30
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Healthy Donors
    InterventionTheralite®; Actilitio®
    PhasePhase 4
    Registry statusActive not recruiting

  • Endodontic Posts Using the CAD/CAM Digital Method.

    NCT07297108 · start 2023-11-30

    Registered record
    Registry ID
    NCT07297108
    Conditions
    Endodontic Treatment; Tooth Restoration
    Interventions
    Lithium Disilicate CAD/CAM Post; Active Comparator: Polymer-Based CAD/CAM Posts
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2023-11-30
    Completion
    2029-11-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndodontic Treatment; Tooth Restoration
    InterventionLithium Disilicate CAD/CAM Post; Active Comparator: Polymer-Based CAD/CAM Posts
    PhaseNot applicable
    Registry statusActive not recruiting

  • Clinical Evaluation of Implants Restored With Advanced Lithium Disilicate Screw-retained Crowns

    NCT05752539 · start 2023-10-10

    Registered record
    Registry ID
    NCT05752539
    Conditions
    Dental Prosthesis Failure; Dental Prosthesis Complication
    Interventions
    CEREC System by Dentsply Sirona
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2023-10-10
    Completion
    2028-02-20
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Prosthesis Failure; Dental Prosthesis Complication
    InterventionCEREC System by Dentsply Sirona
    PhaseNot recorded
    Registry statusActive not recruiting

  • Endogenous Lithium Clearance in Acute Kidney Injury

    NCT05982340 · start 2023-08-01

    Registered record
    Registry ID
    NCT05982340
    Conditions
    Acute Kidney Injury Due to Sepsis; Proximal Tubule Function; Lithium Clearance
    Interventions
    Lithium clearance
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-08-01
    Completion
    2025-05-20
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Kidney Injury Due to Sepsis; Proximal Tubule Function; Lithium Clearance
    InterventionLithium clearance
    PhaseNot recorded
    Registry statusCompleted

  • Digital Decision Support in the Management of Patients With Chest Pain

    NCT05767619 · start 2023-05-15

    Registered record
    Registry ID
    NCT05767619
    Conditions
    Chest Pain; Acute Coronary Syndrome; Chest--Diseases
    Interventions
    Troponin hs-cTnI; Plasma glucose
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-05-15
    Completion
    2027-03
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChest Pain; Acute Coronary Syndrome; Chest--Diseases
    InterventionTroponin hs-cTnI; Plasma glucose
    PhaseNot recorded
    Registry statusRecruiting

  • AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium

    NCT05044611 · start 2023-01-11

    Registered record
    Registry ID
    NCT05044611
    Conditions
    Bipolar Disorder
    Interventions
    Anhydrous Amiloride Hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2023-01-11
    Completion
    2026-01-11
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionAnhydrous Amiloride Hydrochloride; Placebo
    PhasePhase 4
    Registry statusActive not recruiting

  • Endocrown Restoring First Permanent Molar in Children

    NCT06432049 · start 2022-12-05

    Registered record
    Registry ID
    NCT06432049
    Conditions
    Comparing Different Types of Restorations for Restoring Endodontically Treated Permanent First Molar in Children
    Interventions
    restoration for endodontically treated molar
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-12-05
    Completion
    2024-05-13
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComparing Different Types of Restorations for Restoring Endodontically Treated Permanent First Molar in Children
    Interventionrestoration for endodontically treated molar
    PhaseNot applicable
    Registry statusCompleted

  • The Use of Wireless Sensors in Neonatal Intensive Care

    NCT04956354 · start 2022-08-15

    Registered record
    Registry ID
    NCT04956354
    Conditions
    Preterm Birth; Apnea of Newborn
    Interventions
    ANNE™ Monitoring System (2 sensors) - version B; ANNE™ Monitoring System (2 sensors) - version C; ANNE™ Monitoring System (2 sensors) - version C
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2022-08-15
    Completion
    2026-07
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth; Apnea of Newborn
    InterventionANNE™ Monitoring System (2 sensors) - version B; ANNE™ Monitoring System (2 sensors) - version C; ANNE™ Monitoring System (2 sensors) - version C
    PhaseNot recorded
    Registry statusActive not recruiting

  • Clinical Evaluation of Lithium Disilicate and Hybrid Nano-ceramic Anterior Endocrowns (Randomized Clinical Trial)

    NCT04757428 · start 2022-08-11

    Registered record
    Registry ID
    NCT04757428
    Conditions
    Personal Satisfaction
    Interventions
    Endocrown
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-08-11
    Completion
    2023-08-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersonal Satisfaction
    InterventionEndocrown
    PhaseNot applicable
    Registry statusCompleted

  • Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects

    NCT05363293 · start 2022-05-04

    Registered record
    Registry ID
    NCT05363293
    Conditions
    Alzheimer's Disease; Healthy Non-elderly and Elderly Adults
    Interventions
    AL001; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2022-05-04
    Completion
    2023-05-15
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease; Healthy Non-elderly and Elderly Adults
    InterventionAL001; Placebo
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

    NCT03864094 · start 2022-03-15

    Registered record
    Registry ID
    NCT03864094
    Conditions
    Hemodynamic Instability; Anesthesia, General; Anesthesia, Intravenous
    Interventions
    Ephedrine; Phenylephrine; Norepinephrine; Sodium chloride; Propofol; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-03-15
    Completion
    2023-12-14
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodynamic Instability; Anesthesia, General; Anesthesia, Intravenous
    InterventionEphedrine; Phenylephrine; Norepinephrine; Sodium chloride +2 more
    PhasePhase 4
    Registry statusCompleted