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AMR Drug RepurposingSmart Screeningresearch prototype

Lithium Citrate

FDA-approved product (syrup, oral), marketed as Lithium Citrate, Lithonate, Potassium Citrate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Lithium Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Bipolar I disorder
  • Major depressive disorder
  • Renal tubular acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Potassium; Salt solutions
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Lithium Citrate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lithium Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lithium Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Performance of Fiber Reinforced FRC Base and Bonded CAD/CAM Resin Composite Endocrowns Versus Conventional Lithium Disilicate Endocrowns in Posterior Teeth (1y Randomized Clinical Trial).

    NCT05337358 · start 2021-04-01

    Registered record
    Registry ID
    NCT05337358
    Conditions
    Clinical Performance
    Interventions
    endocrown
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-04-01
    Completion
    2023-04-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClinical Performance
    Interventionendocrown
    PhaseNot applicable
    Registry statusUnknown

  • RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)

    NCT05531591 · start 2019-08-01

    Registered record
    Registry ID
    NCT05531591
    Conditions
    Depression; Dementia; Mild Cognitive Impairment; Treatment Resistant Depression; Major Depressive Disorder; Treatment-Refractory Depression; Late Life Depression; Geriatric Depression
    Interventions
    Aripiprazole Augmentation; Bupropion Augmentation; Switch to bupropion; Lithium Augmentation; Switch to nortriptyline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-08-01
    Completion
    2024-07-31
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression; Dementia; Mild Cognitive Impairment; Treatment Resistant Depression +4 more
    InterventionAripiprazole Augmentation; Bupropion Augmentation; Switch to bupropion; Lithium Augmentation +1 more
    PhasePhase 4
    Registry statusCompleted

  • Clinical Assessment of Color Stability and Patient Satisfaction for Polished Versus Glazed Lithium Disilicate Glass Ceramic Restorations and Patient Satisfaction

    NCT03696641 · start 2018-11-01

    Registered record
    Registry ID
    NCT03696641
    Conditions
    Color Change of Lithium Disilicate Crowns
    Interventions
    glazed lithium disilicate crowns; polished lithium disilicate crowns
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-11-01
    Completion
    2019-11-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColor Change of Lithium Disilicate Crowns
    Interventionglazed lithium disilicate crowns; polished lithium disilicate crowns
    PhaseNot applicable
    Registry statusUnknown

  • Clinical Assessement of Glazed Versus Polished Lithium Disilicate Crowns in Surface Roughness and Enamel Antagonists Wear

    NCT03696849 · start 2018-11

    Registered record
    Registry ID
    NCT03696849
    Conditions
    Tooth Decay
    Interventions
    polished emax Press
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-11
    Completion
    2020-01
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTooth Decay
    Interventionpolished emax Press
    PhaseNot applicable
    Registry statusUnknown

  • SALT Study (Switching to the Administration of Lithium Slow -Release Treatment)

    NCT03210480 · start 2017-03-28

    Registered record
    Registry ID
    NCT03210480
    Conditions
    Bipolar Disorder
    Interventions
    Lithium sulphate prolonged-release 660 mg; Lithium carbonate immediate-release 150 mg and 300 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-03-28
    Completion
    2019-09-20
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionLithium sulphate prolonged-release 660 mg; Lithium carbonate immediate-release 150 mg and 300 mg
    PhasePhase 4
    Registry statusTerminated

  • Lithium Versus Quetiapine in Treatment Resistant Depression

    NCT03004521 · start 2016-11

    Registered record
    Registry ID
    NCT03004521
    Conditions
    Depressive Disorder, Treatment-Resistant
    Interventions
    Quetiapine; Lithium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-11
    Completion
    2021-08
    Enrolment
    276

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepressive Disorder, Treatment-Resistant
    InterventionQuetiapine; Lithium
    PhasePhase 4
    Registry statusUnknown

  • Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients

    NCT02630888 · start 2014-08

    Registered record
    Registry ID
    NCT02630888
    Conditions
    Bipolar Disorder
    Interventions
    Memantine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-08
    Completion
    2020-09
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionMemantine; Placebo
    PhasePhase 2
    Registry statusUnknown

  • Randomized, Placebo-controlled Multicenter Trial of Lithium Plus Treatment as Usual (TAU) for Acute Suicidal Ideation and Behavior in Patients With Suicidal Major Depressive Episode

    NCT02039479 · start 2014-01

    Registered record
    Registry ID
    NCT02039479
    Conditions
    Suicidal Ideation/Behavior; Depression
    Interventions
    Lithium Carbonate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2014-01
    Completion
    2018-06
    Enrolment
    254

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSuicidal Ideation/Behavior; Depression
    InterventionLithium Carbonate; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania

    NCT01893229 · start 2013-09

    Registered record
    Registry ID
    NCT01893229
    Conditions
    Bipolar Disorder
    Interventions
    Lithium; Valproate; Oxcarbazepine; Quetiapine; Olanzapine; Ziprasidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-09
    Completion
    2015-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionLithium; Valproate; Oxcarbazepine; Quetiapine +2 more
    PhasePhase 4
    Registry statusUnknown

  • Performance of IGRAs for TB Infection Diagnosis in Elderly

    NCT01895582 · start 2013-07-17

    Registered record
    Registry ID
    NCT01895582
    Conditions
    Ageing; Tuberculosis
    Interventions
    Blood samples
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2013-07-17
    Completion
    2019-03-17
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAgeing; Tuberculosis
    InterventionBlood samples
    PhaseNot recorded
    Registry statusTerminated

  • Ketamine Plus Lithium in Treatment-Resistant Depression

    NCT01880593 · start 2013-07

    Registered record
    Registry ID
    NCT01880593
    Conditions
    Depression
    Interventions
    Lithium; Ketamine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-07
    Completion
    2016-11
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionLithium; Ketamine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Description of the Use of Quetiapine Extended Release (XR) in Real-life Practice in France. An Observational Study

    NCT01689389 · start 2012-12

    Registered record
    Registry ID
    NCT01689389
    Conditions
    Schizophrenia; Bipolar Episodes
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-12
    Completion
    2014-12
    Enrolment
    2,292

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Bipolar Episodes
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients

    NCT01644747 · start 2012-07-19

    Registered record
    Registry ID
    NCT01644747
    Conditions
    Resistant Depression; Moods Disorders; Unipolar Depression; Bipolar Disorder
    Interventions
    transcranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-07-19
    Completion
    2022-03-01
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionResistant Depression; Moods Disorders; Unipolar Depression; Bipolar Disorder
    Interventiontranscranial Direct Current Stimulation (tDCS) (Eldith DC NeuroConn Stimulator)
    PhasePhase 2
    Registry statusCompleted

  • This is an Open-label, Multi-center, Extension Study Designed to Evaluate the Longer Term Safety, Tolerability and Effectiveness of Lurasidone, Flexibly Dosed, Adjunctive to Lithium or Divalproex for the Treatment of Subjects With Bipolar I Disorder Who Have Participated in Study D1050296

    NCT01575561 · start 2012-06

    Registered record
    Registry ID
    NCT01575561
    Conditions
    Bipolar I Disorder
    Interventions
    Lurasidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-06
    Completion
    2015-07
    Enrolment
    377

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionLurasidone
    PhasePhase 3
    Registry statusCompleted

  • Neuroprotective Effects of Lithium in Patients With Small Cell Lung Cancer Undergoing Radiation Therapy to the Brain

    NCT01553916 · start 2012-04-26

    Registered record
    Registry ID
    NCT01553916
    Conditions
    Small Cell Lung Carcinoma
    Interventions
    Lithium Carbonate; Prophylactic cranial irradiation
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-04-26
    Completion
    2017-06-05
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSmall Cell Lung Carcinoma
    InterventionLithium Carbonate; Prophylactic cranial irradiation
    PhasePhase 1 / Phase 2
    Registry statusCompleted