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AMR Drug RepurposingSmart Screeningresearch prototype

Lithium Citrate

FDA-approved product (syrup, oral), marketed as Lithium Citrate, Lithonate, Potassium Citrate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Lithium Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Bipolar I disorder
  • Major depressive disorder
  • Renal tubular acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Potassium; Salt solutions
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Lithium Citrate, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lithium Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lithium Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety of Ramelteon Sublingual in Adult Patients With Acute Depressive Episodes Associated With Bipolar I Disorder

    NCT01467700 · start 2011-12

    Registered record
    Registry ID
    NCT01467700
    Conditions
    Acute Depressive Episode
    Interventions
    Ramelteon SL; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2011-12
    Completion
    2015-03
    Enrolment
    490

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Depressive Episode
    InterventionRamelteon SL; Placebo
    PhasePhase 3
    Registry statusTerminated

  • Wake Therapy in the Treatment of Depression

    NCT01431573 · start 2011-07

    Registered record
    Registry ID
    NCT01431573
    Conditions
    Major Depressive Disorder; Bipolar Disorder
    Interventions
    Wake Therapy; light box; Lithium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2016-08
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Bipolar Disorder
    InterventionWake Therapy; light box; Lithium
    PhaseNot applicable
    Registry statusCompleted

  • Overnight Use of Electroacustimulation on Postoperative Nausea and Vomiting in the Outpatient Surgery Population

    NCT01394536 · start 2011-06

    Registered record
    Registry ID
    NCT01394536
    Conditions
    Post-operative Nausea and Vomiting
    Interventions
    Battery-operated electroacustimulation device (Inactive); Battery-operated electroacustimulation device (Active)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2011-06
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Nausea and Vomiting
    InterventionBattery-operated electroacustimulation device (Inactive); Battery-operated electroacustimulation device (Active)
    PhaseNot applicable
    Registry statusWithdrawn

  • A Pilot Study of Lithium in Progressive Multiple Sclerosis

    NCT01259388 · start 2011-05

    Registered record
    Registry ID
    NCT01259388
    Conditions
    Multiple Sclerosis
    Interventions
    Lithium Carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2011-05
    Completion
    2015-12
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Sclerosis
    InterventionLithium Carbonate
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Decision-Making in Bipolar Disorder

    NCT01463111 · start 2011-05

    Registered record
    Registry ID
    NCT01463111
    Conditions
    Bipolar Disorder
    Interventions
    Lithium; Valproate; Lamotrigine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-05
    Completion
    2016-04
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionLithium; Valproate; Lamotrigine
    PhaseNot applicable
    Registry statusCompleted

  • Lithia Water Study: Effects of Lithia Water on BDNF and Oxidative Stress Markers in Healthy Male Participants

    NCT01257867 · start 2011-03

    Registered record
    Registry ID
    NCT01257867
    Conditions
    Oxidative Stress
    Interventions
    Lithia water; Natural spring water with negligible lithium levels
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-03
    Completion
    2012-10
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxidative Stress
    InterventionLithia water; Natural spring water with negligible lithium levels
    PhaseNot applicable
    Registry statusTerminated

  • Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study

    NCT01754883 · start 2011-01

    Registered record
    Registry ID
    NCT01754883
    Conditions
    Combat Posttraumatic Stess Disorder; Mild Traumatic Brain Injury
    Interventions
    Lithium Carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2011-01
    Completion
    2014-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCombat Posttraumatic Stess Disorder; Mild Traumatic Brain Injury
    InterventionLithium Carbonate
    PhasePhase 1
    Registry statusWithdrawn

  • Colorectal Cancer Detection by Means of Optical Fluoroscopy

    NCT01286064 · start 2010-10

    Registered record
    Registry ID
    NCT01286064
    Conditions
    Colorectal Cancer
    Interventions
    Optical Fluoroscopy; Optical Fluoroscopy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-10
    Completion
    2011-04
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    InterventionOptical Fluoroscopy; Optical Fluoroscopy
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Furosemide on Obesity-induced Glomerular Hyperfiltration

    NCT00962286 · start 2009-09

    Registered record
    Registry ID
    NCT00962286
    Conditions
    Obesity-induced Hyperfiltration
    Interventions
    Furosemide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-09
    Completion
    2010-07
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity-induced Hyperfiltration
    InterventionFurosemide
    PhaseNot applicable
    Registry statusTerminated

  • The Early Medication Change (EMC) Trial

    NCT00974155 · start 2009-09

    Registered record
    Registry ID
    NCT00974155
    Conditions
    Depression
    Interventions
    Escitalopram, venlafaxine, lithium; Escitalopram, venlafaxine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2014-05
    Enrolment
    889

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionEscitalopram, venlafaxine, lithium; Escitalopram, venlafaxine
    PhasePhase 4
    Registry statusCompleted

  • A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS)

    NCT00790582 · start 2008-05

    Registered record
    Registry ID
    NCT00790582
    Conditions
    Amyotrophic Lateral Sclerosis
    Interventions
    lithium carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-03
    Enrolment
    109

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmyotrophic Lateral Sclerosis
    Interventionlithium carbonate
    PhasePhase 2
    Registry statusCompleted

  • Juvenile Bipolar Disorder Outpatient Program

    NCT01000402 · start 2008-02

    Registered record
    Registry ID
    NCT01000402
    Conditions
    Bipolar Disorder; Attention Deficit Disorder With Hyperactivity
    Interventions
    Psychopharmacotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-02
    Completion
    2014-11
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Attention Deficit Disorder With Hyperactivity
    InterventionPsychopharmacotherapy
    PhasePhase 4
    Registry statusUnknown

  • Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury

    NCT00431171 · start 2007-09

    Registered record
    Registry ID
    NCT00431171
    Conditions
    Spinal Cord Injuries
    Interventions
    Lithium carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-09
    Completion
    2010-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Cord Injuries
    InterventionLithium carbonate
    PhasePhase 1
    Registry statusCompleted

  • Safety Study of Depakote Versus Lithium in African Americans With Bipolar Disorder

    NCT01075126 · start 2006-12

    Registered record
    Registry ID
    NCT01075126
    Conditions
    Bipolar Disorder
    Interventions
    Depakote; Lithium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2006-12
    Completion
    2006-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionDepakote; Lithium
    PhasePhase 4
    Registry statusWithdrawn

  • Ph I Study of Lithium During Whole Brain Radiotherapy For Patients With Brain Metastases

    NCT00469937 · start 2006-02

    Registered record
    Registry ID
    NCT00469937
    Conditions
    Brain and Central Nervous System Tumors; Cognitive/Functional Effects; Neurotoxicity; Solid Tumor
    Interventions
    lithium carbonate; cognitive assessment; quality-of-life assessment; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2006-02
    Completion
    2009-03
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain and Central Nervous System Tumors; Cognitive/Functional Effects; Neurotoxicity; Solid Tumor
    Interventionlithium carbonate; cognitive assessment; quality-of-life assessment; radiation therapy
    PhasePhase 1
    Registry statusTerminated