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AMR Drug RepurposingSmart Screeningresearch prototype

Rimegepant Sulfate

FDA-approved product (tablet, orally disintegrating, oral), marketed as Nurtec Odt.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Rimegepant Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Migraine disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Calcitonin gene-related peptide (cgrp) antagonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli61.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis60.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Rimegepant Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Rimegepant Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Open Label Safety Study in Acute Treatment of Migraine

    NCT03266588 · start 2017-08-30

    Registered record
    Registry ID
    NCT03266588
    Conditions
    Migraine, With or Without Aura
    Interventions
    Rimegepant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2017-08-30
    Completion
    2019-07-15
    Enrolment
    3,019

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine, With or Without Aura
    InterventionRimegepant
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Safety and Efficacy in Adult Subjects With Acute Migraines

    NCT03237845 · start 2017-07-27

    Registered record
    Registry ID
    NCT03237845
    Conditions
    Migraine, With or Without Aura
    Interventions
    Rimegepant; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-07-27
    Completion
    2018-01-31
    Enrolment
    1,499

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine, With or Without Aura
    InterventionRimegepant; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study to Evaluate the PK of BMS-927711 in Patient With Migraine During Acute Migraine and Non-migraine Condition

    NCT01445067 · start 2011-11

    Registered record
    Registry ID
    NCT01445067
    Conditions
    Migraine
    Interventions
    BMS-927711 (CGRP Antagonist); BMS-927711 (CGRP Antagonist)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-11
    Completion
    2012-09
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionBMS-927711 (CGRP Antagonist); BMS-927711 (CGRP Antagonist)
    PhasePhase 1
    Registry statusCompleted

  • Dose Ranging Study of Rimegepant (BMS-927711) for the Acute Treatment of Migraine

    NCT01430442 · start 2011-10

    Registered record
    Registry ID
    NCT01430442
    Conditions
    Migraine; Acute Treatment of Migraine
    Interventions
    Rimegepant; Placebo; Sumatriptan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-10
    Completion
    2012-05
    Enrolment
    1,026

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine; Acute Treatment of Migraine
    InterventionRimegepant; Placebo; Sumatriptan
    PhasePhase 2
    Registry statusCompleted

  • An Open-label, Intermediate Size, Expanded Access Study of BHV-3000 in the Acute Treatment of Migraine

    NCT03934086

    Registered record
    Registry ID
    NCT03934086
    Conditions
    Migraine
    Interventions
    rimegepant
    Study type
    EXPANDED_ACCESS
    Phase
    Not recorded
    Registry status
    No longer available
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    Interventionrimegepant
    PhaseNot recorded
    Registry statusNo longer available