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AMR Drug RepurposingSmart Screeningresearch prototype

Olanzapine

FDA-approved product (tablet, oral), marketed as Olanzapine, Zyprexa, Zyprexa Zydis and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Olanzapine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Agitation
  • Bipolar disorder
  • Bipolar I disorder
  • Major depressive disorder
  • Mental or behavioural disorder
  • Psychosis
  • Schizoaffective disorder
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diazepines, oxazepines, thiazepines and oxepines
FDA pharmacologic class
Atypical Antipsychotic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae20.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis60.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Olanzapine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Olanzapine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Patient's Preference Between Conventional Oral Olanzapine Tablet vs Olanzapine Orodispersible Tablet

    NCT00324051 · start 2006-05

    Registered record
    Registry ID
    NCT00324051
    Conditions
    Schizophrenia
    Interventions
    olanzapine therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-05
    Completion
    2007-09
    Enrolment
    284

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Interventionolanzapine therapy
    PhasePhase 4
    Registry statusCompleted

  • Unraveling the Relation of Patient's Profile and Therapeutical Effects of Atypicals, Including Quetiapine Effect

    NCT00534222 · start 2005-09

    Registered record
    Registry ID
    NCT00534222
    Conditions
    Mania; Schizophrenia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-09
    Completion
    2007-12
    Enrolment
    387

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMania; Schizophrenia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy and Safety of Asenapine With Placebo and Olanzapine (41021)(P05933)

    NCT00156117 · start 2005-05-12

    Registered record
    Registry ID
    NCT00156117
    Conditions
    Schizophrenia
    Interventions
    asenapine; Placebo; olanzapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-05-12
    Completion
    2006-05-30
    Enrolment
    417

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Interventionasenapine; Placebo; olanzapine
    PhasePhase 3
    Registry statusCompleted

  • Bifeprunox in the Treatment of Schizophrenia

    NCT00193713 · start 2005-05

    Registered record
    Registry ID
    NCT00193713
    Conditions
    Schizophrenia
    Interventions
    bifeprunox
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-05
    Completion
    2006-11
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Interventionbifeprunox
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (25543)(COMPLETED)(P05817)

    NCT00212836 · start 2005-04-21

    Registered record
    Registry ID
    NCT00212836
    Conditions
    Schizophrenia
    Interventions
    asenapine; olanzapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-04-21
    Completion
    2007-08-02
    Enrolment
    481

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Interventionasenapine; olanzapine
    PhasePhase 3
    Registry statusCompleted

  • 3-week Study of Asenapine, Olanzapine and Placebo for Treatment of Bipolar Mania (P07009)

    NCT00159796 · start 2004-12-14

    Registered record
    Registry ID
    NCT00159796
    Conditions
    Bipolar Disorder
    Interventions
    Asenapine; Olanzapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-12-14
    Completion
    2006-04-28
    Enrolment
    489

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionAsenapine; Olanzapine; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Continuing Olanzapine to Switching to Quetiapine in Overweight or Obese Patients With Schizophrenia and Schizoaffective Disorder

    NCT00090012 · start 2004-07

    Registered record
    Registry ID
    NCT00090012
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    Olanzapine; Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-07
    Completion
    2006-03
    Enrolment
    340

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    InterventionOlanzapine; Quetiapine
    PhasePhase 4
    Registry statusCompleted

  • Study Comparing Patients Taking Olanzapine and Patients Taking Aripiprazole on Learning of Vocational Skills

    NCT00223418 · start 2004-01

    Registered record
    Registry ID
    NCT00223418
    Conditions
    Schizophenia Disorder; Schizoaffective Disorder
    Interventions
    aripiprazole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-01
    Completion
    2007-06
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophenia Disorder; Schizoaffective Disorder
    Interventionaripiprazole
    PhaseNot applicable
    Registry statusCompleted

  • Olanzapine Versus Comparator in the Treatment of Bipolar Disorder

    NCT00485680 · start 2003-12

    Registered record
    Registry ID
    NCT00485680
    Conditions
    Bipolar Disorder
    Interventions
    Olanzapine Hydrochloride; Lithium Carbonate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-12
    Completion
    2005-06
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionOlanzapine Hydrochloride; Lithium Carbonate
    PhasePhase 3
    Registry statusCompleted

  • Risperdal Consta for Bipolar Disorder

    NCT00177164 · start 2003-11

    Registered record
    Registry ID
    NCT00177164
    Conditions
    Bipolar I Disorder
    Interventions
    Injectable Risperidone (Consta) or oral antipsychotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-11
    Completion
    2009-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionInjectable Risperidone (Consta) or oral antipsychotic
    PhasePhase 3
    Registry statusCompleted

  • A Comparison of Two Standard Therapies in the Management of Dementia With Agitation

    NCT00208819 · start 2003-09

    Registered record
    Registry ID
    NCT00208819
    Conditions
    Senile Dementia, Alzheimer Type; Dementia, Alzheimer Type; Alzheimer Disease; Dementia
    Interventions
    risperidone; quetiapine; olanzapine; divalproex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-09
    Completion
    2007-07
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSenile Dementia, Alzheimer Type; Dementia, Alzheimer Type; Alzheimer Disease; Dementia
    Interventionrisperidone; quetiapine; olanzapine; divalproex
    PhasePhase 4
    Registry statusCompleted

  • A Controlled Study of Olanzapine in Children With Autism

    NCT00057408 · start 2003-05

    Registered record
    Registry ID
    NCT00057408
    Conditions
    Autistic Disorder
    Interventions
    olanzapine (Zyprexa); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-05
    Completion
    2005-09
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutistic Disorder
    Interventionolanzapine (Zyprexa); Placebo
    PhasePhase 2
    Registry statusCompleted

  • Weight Gain Management in Patients With Schizophrenia

    NCT00486005 · start 2003-02

    Registered record
    Registry ID
    NCT00486005
    Conditions
    Schizophrenia
    Interventions
    Olanzapine Hydrochloride; Nizatidine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-02
    Completion
    2003-10
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionOlanzapine Hydrochloride; Nizatidine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode

    NCT01977300 · start 2003-01

    Registered record
    Registry ID
    NCT01977300
    Conditions
    Bipolar I Disorder
    Interventions
    Valproate; Lithium; Risperidone; Olanzapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-01
    Completion
    2011-08
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionValproate; Lithium; Risperidone; Olanzapine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI

    NCT01234454 · start 2002-01

    Registered record
    Registry ID
    NCT01234454
    Conditions
    Schizophrenia
    Interventions
    Risperidone; Olanzapine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2002-01
    Completion
    2007-12
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionRisperidone; Olanzapine
    PhaseNot applicable
    Registry statusCompleted