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AMR Drug RepurposingSmart Screeningresearch prototype

Tromethamine

FDA-approved product (solution, injection), marketed as Tham, Tromethamine.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Tromethamine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Solutions affecting the electrolyte balance; Other i.v. solution additives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Tromethamine, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA7.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli8.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis9.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tromethamine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tromethamine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Ph 2 Study of Fosbretabulin in Subjects w Pancreatic or Gastrointestinal Neuroendocrine Tumors w Elevated Biomarkers

    NCT02132468 · start 2014-09

    Registered record
    Registry ID
    NCT02132468
    Conditions
    Neuroendocrine Tumors
    Interventions
    fosbretabulin tromethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09
    Completion
    2016-08
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuroendocrine Tumors
    Interventionfosbretabulin tromethamine
    PhasePhase 2
    Registry statusCompleted

  • IV Dexketoprofen vs Placebo in Migranie Attack

    NCT02159547 · start 2014-05

    Registered record
    Registry ID
    NCT02159547
    Conditions
    Migraine
    Interventions
    Dexketoprofen; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-05
    Completion
    2014-08
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionDexketoprofen; Normal Saline
    PhasePhase 4
    Registry statusCompleted

  • A Prospective Randomized Double-Blind Trial Comparing 3 Doses of Intravenous Ketorolac for Pain Management

    NCT02078492 · start 2014-03

    Registered record
    Registry ID
    NCT02078492
    Conditions
    Pain
    Interventions
    10 mg of Ketorolac; 15 mg of Ketorolac; 30 mg of Ketorolac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-03
    Completion
    2015-12
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    Intervention10 mg of Ketorolac; 15 mg of Ketorolac; 30 mg of Ketorolac
    PhasePhase 4
    Registry statusCompleted

  • Intravenous Paracetamol Compared Dexketoprofen for Postoperative Analgesia After Septoplasty

    NCT02602197 · start 2013-08

    Registered record
    Registry ID
    NCT02602197
    Conditions
    Postoperative Pain
    Interventions
    Paracetamol; Dexketoprofen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2013-08
    Completion
    2016-02
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionParacetamol; Dexketoprofen
    PhasePhase 3
    Registry statusUnknown

  • Safety, Efficacy and Pharmacokinetics of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification

    NCT01579565 · start 2012-04

    Registered record
    Registry ID
    NCT01579565
    Conditions
    Intraocular Lens Replacement
    Interventions
    OMS302; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-04
    Completion
    2013-01
    Enrolment
    416

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntraocular Lens Replacement
    InterventionOMS302; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Dose Response of Ketorolac in Knee Arthroscopy

    NCT02181426 · start 2012-03

    Registered record
    Registry ID
    NCT02181426
    Conditions
    Meniscectomy
    Interventions
    Ketorolac Dose
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-03
    Completion
    2016-12-15
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeniscectomy
    InterventionKetorolac Dose
    PhaseNot applicable
    Registry statusCompleted

  • Intramuscular Ketorolac Versus Oral Ibuprofen for Pain Relief in First Trimester Suction Curettage

    NCT01595282 · start 2011-06

    Registered record
    Registry ID
    NCT01595282
    Conditions
    Pain
    Interventions
    Ketorolac; Ibuprofen
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-06
    Completion
    2012-06
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionKetorolac; Ibuprofen
    PhaseNot applicable
    Registry statusCompleted

  • Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain

    NCT01307020 · start 2011-02

    Registered record
    Registry ID
    NCT01307020
    Conditions
    Pain
    Interventions
    Dexketoprofen Trometamol; Dexketoprofen Trometamol; Tramadol Hydrochloride; Tramadol Hydrochloride; Ibuprofen; Placebo; Dexketoprofen Trometamol + Tramadol Hydrochloride; Dexketoprofen Trometamol + Tramadol Hydrochloride; Dexketoprofen Trometamol + Tramadol Hydrochloride; Dexketoprofen Trometamol + Tramadol Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-02
    Completion
    2011-10
    Enrolment
    745

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionDexketoprofen Trometamol; Dexketoprofen Trometamol; Tramadol Hydrochloride; Tramadol Hydrochloride +6 more
    PhasePhase 2
    Registry statusCompleted

  • Comparison of Topical Ketorolac 0,4% Versus Placebo in Cataract Surgery

    NCT01542190 · start 2011-02

    Registered record
    Registry ID
    NCT01542190
    Conditions
    Cystoid Macular Edema Following Cataract Surgery, Bilateral
    Interventions
    Ketorolac Tromethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-02
    Completion
    2013-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystoid Macular Edema Following Cataract Surgery, Bilateral
    InterventionKetorolac Tromethamine
    PhasePhase 4
    Registry statusCompleted

  • IV Paracetamol, Dexketoprofen or Morphine for the Treatment of Low Back Pain

    NCT01422291 · start 2011-01

    Registered record
    Registry ID
    NCT01422291
    Conditions
    Low Back Pain
    Interventions
    paracetamol; morphine; Dexketoprofen; Paracetamole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-07
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    Interventionparacetamol; morphine; Dexketoprofen; Paracetamole
    PhasePhase 4
    Registry statusCompleted

  • Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)

    NCT01326260 · start 2010-07

    Registered record
    Registry ID
    NCT01326260
    Conditions
    Resuscitation, Trauma Patients
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2010-07
    Completion
    2015-05
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionResuscitation, Trauma Patients
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Magnesium Sulfate Improves Postoperative Analgesia in Laparoscopic Gynecologic Surgeries

    NCT02508857 · start 2010-01

    Registered record
    Registry ID
    NCT02508857
    Conditions
    Pain, Postoperative
    Interventions
    Ketorolac; Magnesium; Saline solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-01
    Completion
    2014-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    InterventionKetorolac; Magnesium; Saline solution
    PhasePhase 4
    Registry statusCompleted

  • Tobramycin-Dexamethasone Versus Tobramycin-Dexamethasone Plus Ketorolac After Phacoemulsification Surgery

    NCT00992355 · start 2009-01

    Registered record
    Registry ID
    NCT00992355
    Conditions
    Cataract
    Interventions
    Tobramycin 0.3% - Dexamethasone 0.1%; Tobramycin 0.3% - Dexamethasone 0.1% plus Ketorolac tromethamine 0.5%
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-04
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract
    InterventionTobramycin 0.3% - Dexamethasone 0.1%; Tobramycin 0.3% - Dexamethasone 0.1% plus Ketorolac tromethamine 0.5%
    PhaseNot applicable
    Registry statusCompleted

  • Modulation of Remifentanil-induced Postinfusion Hyperalgesia

    NCT00785863 · start 2008-12

    Registered record
    Registry ID
    NCT00785863
    Conditions
    Hyperalgesia, Secondary
    Interventions
    Placebo; Remifentanil; Ketorolac and remifentanil; Parecoxib and remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-12
    Completion
    2009-04
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperalgesia, Secondary
    InterventionPlacebo; Remifentanil; Ketorolac and remifentanil; Parecoxib and remifentanil
    PhasePhase 4
    Registry statusCompleted

  • A Phase I Study to Evaluate Safety and Immunogenicity of AERAS 404 (C-011-404)

    NCT02109874 · start 2008-12

    Registered record
    Registry ID
    NCT02109874
    Conditions
    Tuberculosis
    Interventions
    AERAS-404 (mcg H4/nmol IC31); Sterile buffer containing 10 mmol/L tris and 169 mmol/L NaCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionAERAS-404 (mcg H4/nmol IC31); Sterile buffer containing 10 mmol/L tris and 169 mmol/L NaCl
    PhasePhase 1
    Registry statusCompleted