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AMR Drug RepurposingSmart Screeningresearch prototype

Tromethamine

FDA-approved product (solution, injection), marketed as Tham, Tromethamine.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Tromethamine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acidosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Solutions affecting the electrolyte balance; Other i.v. solution additives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Tromethamine, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA7.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli8.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis9.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tromethamine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tromethamine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Anesthetics and Analgesics in Children

    NCT03427736 · start 2018-12-13

    Registered record
    Registry ID
    NCT03427736
    Conditions
    Anesthesia; Pain
    Interventions
    Ketorolac Tromethamine; Hydromorphone; Ketamine; Oxycodone; Morphine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2018-12-13
    Completion
    2027-09-09
    Enrolment
    551

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Pain
    InterventionKetorolac Tromethamine; Hydromorphone; Ketamine; Oxycodone +1 more
    PhaseNot recorded
    Registry statusRecruiting

  • Comparison of Drugs on Headache Treatment After ECT Treatment

    NCT03830398 · start 2018-11-20

    Registered record
    Registry ID
    NCT03830398
    Conditions
    Mental Disorders
    Interventions
    Paracetamol; Deksketoprofen trometamol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-11-20
    Completion
    2019-06
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMental Disorders
    InterventionParacetamol; Deksketoprofen trometamol; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Relieving Acute Pain (RAP) Study: A Pilot Study

    NCT03426137 · start 2018-09-17

    Registered record
    Registry ID
    NCT03426137
    Conditions
    Trauma; Opioid Use; Spine Fusion
    Interventions
    Oxycodone; Ketorolac; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2018-09-17
    Completion
    2020-01-21
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrauma; Opioid Use; Spine Fusion
    InterventionOxycodone; Ketorolac; Placebo
    PhasePhase 2
    Registry statusTerminated

  • A Phase I Clinical Study Trial of Felbinac Trometamol Injection in China

    NCT03617510 · start 2018-07-10

    Registered record
    Registry ID
    NCT03617510
    Conditions
    Pain
    Interventions
    Felbinac Trometamol Injection; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-07-10
    Completion
    2019-04-30
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionFelbinac Trometamol Injection; Placebos
    PhasePhase 1
    Registry statusCompleted

  • Oral Tramadol Versus Oral Dexketoprofen for Reducing Pain During Office Hysteroscopy

    NCT03585036 · start 2018-07

    Registered record
    Registry ID
    NCT03585036
    Conditions
    Hysteroscopy
    Interventions
    dexketoprofen; Tramadol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2018-07
    Completion
    2018-10
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHysteroscopy
    Interventiondexketoprofen; Tramadol; Placebo
    PhasePhase 3
    Registry statusUnknown

  • Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy

    NCT03394001 · start 2018-01-01

    Registered record
    Registry ID
    NCT03394001
    Conditions
    Anesthesia
    Interventions
    Wound infiltration; Lidocaine Hydrochloride; Ketorolac tromethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-01-01
    Completion
    2018-06
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionWound infiltration; Lidocaine Hydrochloride; Ketorolac tromethamine
    PhasePhase 4
    Registry statusUnknown

  • Study of Ketorolac Versus Opioid for Pain After Endoscopy

    NCT03888144 · start 2017-10-13

    Registered record
    Registry ID
    NCT03888144
    Conditions
    Kidney Calculi; Ureteral Calculi
    Interventions
    Oxycodone; Ketorolac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-13
    Completion
    2021-08-01
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Calculi; Ureteral Calculi
    InterventionOxycodone; Ketorolac
    PhasePhase 4
    Registry statusCompleted

  • Impact of Preemptive Intravenous Ibuprofen on Postoperative Edema and Trismus in the Third Molar Teeth

    NCT03170713 · start 2017-05-15

    Registered record
    Registry ID
    NCT03170713
    Conditions
    Trismus; Edema
    Interventions
    arveles; intrafen; placebos
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-05-15
    Completion
    2017-11-15
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrismus; Edema
    Interventionarveles; intrafen; placebos
    PhaseNot applicable
    Registry statusUnknown

  • Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

    NCT02958566 · start 2017-01

    Registered record
    Registry ID
    NCT02958566
    Conditions
    Colon Cancer; Colon Diverticulosis; Colonic Neoplasms; Colonic Diverticulitis; Pain, Postoperative; Ileus; Ileus Paralytic; Ileus; Mechanical; Constipation Drug Induced; Constipation; Rectum Cancer; Rectum Neoplasm
    Interventions
    Acetaminophen; Gabapentin; Orphenadrine; Lidocaine; Marcaine; Ketamine; Methadone; Tramadol; Ketorolac; Morphine Sulfate; Fentanyl; Dilaudid; Hydrocodone-Acetaminophen Tab 5-325 MG; Morphine Sulfate; Fentanyl; Dilaudid; HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-01
    Completion
    2018-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColon Cancer; Colon Diverticulosis; Colonic Neoplasms; Colonic Diverticulitis +9 more
    InterventionAcetaminophen; Gabapentin; Orphenadrine; Lidocaine +13 more
    PhasePhase 4
    Registry statusUnknown

  • Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty

    NCT02987920 · start 2017-01

    Registered record
    Registry ID
    NCT02987920
    Conditions
    Pain, Postoperative
    Interventions
    Dextromethorphan; Placebo - Concentrate; Acetaminophen; Oxycodone; Celecoxib; Pantoprazole; Ketorolac; Gabapentin; Hydromorphone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-01
    Completion
    2018-01
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    InterventionDextromethorphan; Placebo - Concentrate; Acetaminophen; Oxycodone +5 more
    PhasePhase 4
    Registry statusTerminated

  • Status Migrainosus - Differentiating Between Responders and Non-responders

    NCT03066544 · start 2016-11-30

    Registered record
    Registry ID
    NCT03066544
    Conditions
    Migraine
    Interventions
    Bupivacaine; Naratriptan Pill; Dexamethasone; Ketorolac
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2016-11-30
    Completion
    2020-06-30
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionBupivacaine; Naratriptan Pill; Dexamethasone; Ketorolac
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Multimodal Pain Management for Cesarean Delivery

    NCT02922985 · start 2016-10

    Registered record
    Registry ID
    NCT02922985
    Conditions
    Pain
    Interventions
    Intravenous acetominophen; Ketorolac, intramuscular; Bupivacaine, subcutaneous; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-10
    Completion
    2017-07
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionIntravenous acetominophen; Ketorolac, intramuscular; Bupivacaine, subcutaneous; Normal saline
    PhasePhase 4
    Registry statusCompleted

  • Premedication Efficacy of Ketorolac Infiltration on Post Endodontic Pain

    NCT02923687 · start 2016-09

    Registered record
    Registry ID
    NCT02923687
    Conditions
    Irreversible Pulpitis
    Interventions
    Ketorolac Tromethamine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-09
    Completion
    2017-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIrreversible Pulpitis
    InterventionKetorolac Tromethamine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Safety of Chlamydia Vaccine CTH522 in Healthy Women Aged 18 to 45 Years

    NCT02787109 · start 2016-07

    Registered record
    Registry ID
    NCT02787109
    Conditions
    Chlamydia Trachomatis
    Interventions
    CTH522-CAF01; CTH522-Al(OH)3; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-07
    Completion
    2017-07-31
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChlamydia Trachomatis
    InterventionCTH522-CAF01; CTH522-Al(OH)3; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Auricular Acupuncture vs SOC in Migraine HA

    NCT02681211 · start 2016-02

    Registered record
    Registry ID
    NCT02681211
    Conditions
    Migraine Headache
    Interventions
    Auricular Acupuncture; Ketorolac 0.5mg/kg, max 30mg; Metoclopramide 0.1 mg/kg, max 10mg; Diphenhydramine 1mg/kg, max 50mg; Normal saline fluid bolus 20mL/kg, max 1000mL
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-02
    Completion
    2024-11
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Headache
    InterventionAuricular Acupuncture; Ketorolac 0.5mg/kg, max 30mg; Metoclopramide 0.1 mg/kg, max 10mg; Diphenhydramine 1mg/kg, max 50mg +1 more
    PhaseNot applicable
    Registry statusUnknown