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AMR Drug RepurposingSmart Screeningresearch prototype

Telithromycin

FDA-approved product (tablet, oral), marketed as Ketek.

Registered studies
26
Lab records
11
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Telithromycin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Bacterial pneumonia
  • Chronic bronchitis
  • Community-Acquired Infections
  • Infection
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis
  • Sinusitis
  • Tonsillitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Macrolides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01FA15

Repurposing investigation

Telithromycin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli73.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis52.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

26registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 9 of 11 lab records
Open Telithromycin in ChEMBL Registered studies below
Show the 11 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Telithromycin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery

    NCT00925756 · start 2008-10-20

    Registered record
    Registry ID
    NCT00925756
    Conditions
    HIV Infections
    Interventions
    Maraviroc
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-10-20
    Completion
    2014-04-11
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionMaraviroc
    PhasePhase 4
    Registry statusCompleted

  • TELI TON - Telithromycin in Tonsillitis

    NCT00315042 · start 2006-03

    Registered record
    Registry ID
    NCT00315042
    Conditions
    Tonsillitis; Pharyngitis
    Interventions
    Telithromycin (HMR3647); Penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-03
    Completion
    2006-08
    Enrolment
    314

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis; Pharyngitis
    InterventionTelithromycin (HMR3647); Penicillin
    PhasePhase 3
    Registry statusTerminated

  • TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults

    NCT00315549 · start 2006-02

    Registered record
    Registry ID
    NCT00315549
    Conditions
    Tonsillitis; Pharyngitis
    Interventions
    Telithromycin; Penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-02
    Completion
    2006-09
    Enrolment
    233

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis; Pharyngitis
    InterventionTelithromycin; Penicillin
    PhasePhase 3
    Registry statusTerminated

  • Telithromycin in Acute Exacerbation of Chronic Bronchitis

    NCT00288223 · start 2006-01

    Registered record
    Registry ID
    NCT00288223
    Conditions
    Bronchitis, Chronic
    Interventions
    Telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-01
    Completion
    2007-01
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchitis, Chronic
    InterventionTelithromycin
    PhasePhase 4
    Registry statusTerminated

  • TELI COM - Telithromycin in Children With Otitis Media

    NCT00315003 · start 2006-01

    Registered record
    Registry ID
    NCT00315003
    Conditions
    Otitis Media, Suppurative; Otitis Media, Purulent
    Interventions
    Telithromycin; Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-01
    Completion
    2006-07
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Media, Suppurative; Otitis Media, Purulent
    InterventionTelithromycin; Azithromycin
    PhasePhase 3
    Registry statusTerminated

  • Intrapulmonary Pharmacokinetics of Antibiotics

    NCT00315601 · start 2006-01

    Registered record
    Registry ID
    NCT00315601
    Conditions
    Healthy
    Interventions
    Telithromycin; azithromycin; bronchoalveolar lavage; Telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-01
    Completion
    2006-11
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTelithromycin; azithromycin; bronchoalveolar lavage; Telithromycin
    PhasePhase 4
    Registry statusTerminated

  • Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis

    NCT00245440 · start 2005-12

    Registered record
    Registry ID
    NCT00245440
    Conditions
    Maxillary Sinusitis
    Interventions
    Azithromycin; Telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-12
    Completion
    2006-07
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMaxillary Sinusitis
    InterventionAzithromycin; Telithromycin
    PhasePhase 4
    Registry statusTerminated

  • Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia

    NCT00270517 · start 2005-12

    Registered record
    Registry ID
    NCT00270517
    Conditions
    Community Acquired Pneumonia
    Interventions
    EDP-420 / Duration of Treatment - 3 days; Telithromycin / Duration of Treatment - 7 days
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2005-12
    Completion
    2007-07
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity Acquired Pneumonia
    InterventionEDP-420 / Duration of Treatment - 3 days; Telithromycin / Duration of Treatment - 7 days
    PhasePhase 2
    Registry statusUnknown

  • Study Comparing the Clinical Efficacy and Health Outcomes of Outpatients With Mild to Moderate Community-Acquired Pneumonia (CAP) Treated With Either Telithromycin Once Daily for 7 Days, or Azithromycin Once Daily for 5 Days

    NCT00237445 · start 2005-11

    Registered record
    Registry ID
    NCT00237445
    Conditions
    Pneumonia
    Interventions
    telithromycin; azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-11
    Completion
    2006-09
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    Interventiontelithromycin; azithromycin
    PhasePhase 4
    Registry statusTerminated

  • Outpatient Registry Trial of Respiratory Tract Infections in Adults

    NCT00245453 · start 2005-10

    Registered record
    Registry ID
    NCT00245453
    Conditions
    Pneumonia, Bacterial; Bronchitis, Chronic
    Interventions
    azithromycin; telithromycin; Clarythromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2005-10
    Completion
    2006-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Bacterial; Bronchitis, Chronic
    Interventionazithromycin; telithromycin; Clarythromycin
    PhasePhase 4
    Registry statusWithdrawn

  • Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus

    NCT00351182 · start 2005-09

    Registered record
    Registry ID
    NCT00351182
    Conditions
    Scrub Typhus
    Interventions
    Telithromycin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-09
    Completion
    2005-12
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScrub Typhus
    InterventionTelithromycin; Doxycycline
    PhasePhase 3
    Registry statusCompleted

  • Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections

    NCT00174811 · start 2005-06

    Registered record
    Registry ID
    NCT00174811
    Conditions
    Otitis Media
    Interventions
    telithromycin (HMR3647)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2005-06
    Completion
    2006-06
    Enrolment
    639

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Media
    Interventiontelithromycin (HMR3647)
    PhasePhase 3
    Registry statusTerminated

  • Telithromycin in Respiratory Tract Infections

    NCT00261105 · start 2005-02

    Registered record
    Registry ID
    NCT00261105
    Conditions
    Respiratory Tract Infections
    Interventions
    telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-02
    Completion
    2005-12
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Tract Infections
    Interventiontelithromycin
    PhasePhase 4
    Registry statusCompleted

  • Comparative Effects of Azithromycin, Telithromycin and Levofloxacin on Drug Metabolizing Enzymes

    NCT00164112 · start 2004-11

    Registered record
    Registry ID
    NCT00164112
    Conditions
    Healthy
    Interventions
    Cooperstown 5+1 alone; Azithromycin plus Cooperstown 5+1; Telithromycin plus Cooperstown 5+1; Levofloxacin plus Cooperstown 5+1
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-11
    Completion
    2005-06
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCooperstown 5+1 alone; Azithromycin plus Cooperstown 5+1; Telithromycin plus Cooperstown 5+1; Levofloxacin plus Cooperstown 5+1
    PhasePhase 4
    Registry statusCompleted

  • CHOOSE : Telithromycin, Acute Bacterial Sinusitis

    NCT00174694 · start 2004-11

    Registered record
    Registry ID
    NCT00174694
    Conditions
    Sinusitis
    Interventions
    Telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-11
    Completion
    Not recorded
    Enrolment
    298

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionTelithromycin
    PhasePhase 4
    Registry statusCompleted