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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocodone Bitartrate

FDA-approved product (capsule, extended release, oral), marketed as Hydrocodone Bitartrate, Hysingla Er, Vantrela Er and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Hydrocodone Bitartrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cough
  • Drug dependence
  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids; Opium alkaloids and derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA44.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae46.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocodone Bitartrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocodone Bitartrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Scheduled or As Needed Pain Regimen?

    NCT06495632 · start 2024-08-01

    Registered record
    Registry ID
    NCT06495632
    Conditions
    Pain, Postoperative
    Interventions
    Motrin and narcotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-08-01
    Completion
    2027-07-31
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    InterventionMotrin and narcotic
    PhasePhase 4
    Registry statusRecruiting

  • Effectiveness of Percutaneous Neuromodulation vs Pharmacological Treatment in Cancer Patients With Anterior Knee Pain

    NCT06240390 · start 2024-05-01

    Registered record
    Registry ID
    NCT06240390
    Conditions
    Pain Cancer
    Interventions
    Ultrasound-guided percutaneous neuromodulation (NMP); pharmacological treatment by Opioids
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2024-05-01
    Completion
    2025-02-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain Cancer
    InterventionUltrasound-guided percutaneous neuromodulation (NMP); pharmacological treatment by Opioids
    PhaseNot applicable
    Registry statusWithdrawn

  • Hydrocodone Compared to Acetaminophen and Ibuprofen for Post-nail Procedure Analgesia

    NCT05544734 · start 2022-11-10

    Registered record
    Registry ID
    NCT05544734
    Conditions
    Nail Diseases; Nail Abnormality
    Interventions
    Hydrocodone 5Mg/Acetaminophen 325Mg Tab; Acetaminophen 1000mg; Ibuprofen 400 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-11-10
    Completion
    2023-06-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNail Diseases; Nail Abnormality
    InterventionHydrocodone 5Mg/Acetaminophen 325Mg Tab; Acetaminophen 1000mg; Ibuprofen 400 mg
    PhasePhase 4
    Registry statusCompleted

  • Personality and Drug Use

    NCT05516823 · start 2022-11

    Registered record
    Registry ID
    NCT05516823
    Conditions
    No Conditions Study Focus on Substance Use and Personality
    Interventions
    Usage of drugs
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-11
    Completion
    2023-11
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNo Conditions Study Focus on Substance Use and Personality
    InterventionUsage of drugs
    PhaseNot recorded
    Registry statusUnknown

  • Evaluation of Efficacy and Safety of Suzetrigine for Acute Pain After an Abdominoplasty

    NCT05558410 · start 2022-10-10

    Registered record
    Registry ID
    NCT05558410
    Conditions
    Acute Pain
    Interventions
    Suzetrigine (SUZ); HB/APAP; Placebo (matched to SUZ); Placebo (matched to HB/APAP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2022-10-10
    Completion
    2023-09-11
    Enrolment
    1,118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionSuzetrigine (SUZ); HB/APAP; Placebo (matched to SUZ); Placebo (matched to HB/APAP)
    PhasePhase 3
    Registry statusCompleted

  • Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects

    NCT05572190 · start 2022-09-27

    Registered record
    Registry ID
    NCT05572190
    Conditions
    Acute Pain
    Interventions
    ETR028, ETR029, [ETR028 + ETR029] or HCBT
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-09-27
    Completion
    2024-03-31
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionETR028, ETR029, [ETR028 + ETR029] or HCBT
    PhasePhase 1
    Registry statusUnknown

  • A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

    NCT04977336 · start 2021-07-19

    Registered record
    Registry ID
    NCT04977336
    Conditions
    Acute Pain
    Interventions
    VX-548; HB/APAP; Placebo (matched to VX-548); Placebo (matched to HB/APAP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-07-19
    Completion
    2022-03-04
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionVX-548; HB/APAP; Placebo (matched to VX-548); Placebo (matched to HB/APAP)
    PhasePhase 2
    Registry statusCompleted

  • Comparing Perioperative Outcomes in Pain Control

    NCT05690282 · start 2021-05-17

    Registered record
    Registry ID
    NCT05690282
    Conditions
    Post-operative Pain
    Interventions
    Multimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2021-05-17
    Completion
    2026-05-17
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Pain
    InterventionMultimodal Pain Management (Ibuprofen/Acetaminophen/GABAPentin/0.25%Bupivacaine)
    PhasePhase 4
    Registry statusActive not recruiting

  • Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures

    NCT03375593 · start 2019-08-01

    Registered record
    Registry ID
    NCT03375593
    Conditions
    Distal Radius Fracture; Pain Management; Metacarpal Fracture
    Interventions
    Hydrocodone 5Mg/Acetaminophen 500Mg Tab; Acetaminophen 500Mg Tab; Ibuprofen 600 mg tab
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-08-01
    Completion
    2022-10-01
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDistal Radius Fracture; Pain Management; Metacarpal Fracture
    InterventionHydrocodone 5Mg/Acetaminophen 500Mg Tab; Acetaminophen 500Mg Tab; Ibuprofen 600 mg tab
    PhasePhase 4
    Registry statusUnknown

  • Supracondylar Humerus Fracture (SCHF) Post-Op Study Between Opioid and Non-Opioid Pain Management

    NCT06187584 · start 2019-04-15

    Registered record
    Registry ID
    NCT06187584
    Conditions
    Supracondylar Humerus Fracture
    Interventions
    Hydrocodone/acetaminophen; Acetaminophen; Ibuprofen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-04-15
    Completion
    2023-12-20
    Enrolment
    137

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSupracondylar Humerus Fracture
    InterventionHydrocodone/acetaminophen; Acetaminophen; Ibuprofen
    PhasePhase 4
    Registry statusCompleted

  • Post-Op Pain Control for Prophylactic Intramedullary Nailing.

    NCT03823534 · start 2019-02-20

    Registered record
    Registry ID
    NCT03823534
    Conditions
    Bone Metastases; Lymphoma; Multiple Myeloma; Opioid Use; Pain
    Interventions
    Ketorolac; Normal saline; Acetaminophen; Oxycodone Acetaminophen; Morphine; Hydrocodone/Acetaminophen; Oxycodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2019-02-20
    Completion
    2027-03-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Metastases; Lymphoma; Multiple Myeloma; Opioid Use +1 more
    InterventionKetorolac; Normal saline; Acetaminophen; Oxycodone Acetaminophen +3 more
    PhasePhase 3
    Registry statusRecruiting

  • Nonopioid Analgesia After Rotator Cuff Repair

    NCT03818919 · start 2019-01-22

    Registered record
    Registry ID
    NCT03818919
    Conditions
    Rotator Cuff Tear
    Interventions
    Celecoxib; Ketorolac; Gabapentin; Acetaminophen; Diazepam; Hydrocodone-Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-01-22
    Completion
    2020-12-31
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear
    InterventionCelecoxib; Ketorolac; Gabapentin; Acetaminophen +2 more
    PhasePhase 2
    Registry statusCompleted

  • Dronabinol Opioid Sparing Evaluation (DOSE) Trial

    NCT03766269 · start 2018-12-01

    Registered record
    Registry ID
    NCT03766269
    Conditions
    Chronic Pain
    Interventions
    Dronabinol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-12-01
    Completion
    2019-07-01
    Enrolment
    280

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Pain
    InterventionDronabinol
    PhasePhase 2
    Registry statusUnknown

  • Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

    NCT03511118 · start 2018-10-04

    Registered record
    Registry ID
    NCT03511118
    Conditions
    Lactating Women on Select DOI; Breastfed Infants of Mothers on Select DOI
    Interventions
    Tranexamic acid (TXA); labetalol; metformin; nifedipine; clindamycin; oxycodone; azithromycin; escitalopram; sertraline; ondansetron; Ciprofloxacin; Doxycycline; Levofloxacin; Methylphenidate; Sumatriptan; Citalopram; Cyclobenzaprine; Furosemide; Gabapentin; Hydrochlorothiazide; Hydroxyurea; Rosuvastatin; Topiramate; Trazodone; Valganciclovir; Venlafaxine; Verapamil; Remdesivir; Anakinra; Tocilizumab; Fluvoxamine; Amoxicillin; Bupropion; Duloxetine; Hydrocodone; Levetiracetam; Paroxetine; Buprenorphine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2018-10-04
    Completion
    2028-07-31
    Enrolment
    1,600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLactating Women on Select DOI; Breastfed Infants of Mothers on Select DOI
    InterventionTranexamic acid (TXA); labetalol; metformin; nifedipine +34 more
    PhaseNot recorded
    Registry statusRecruiting

  • Are NSAIDs Effective Enough for Postoperative Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty

    NCT03605914 · start 2018-08-01

    Registered record
    Registry ID
    NCT03605914
    Conditions
    Pain Control After Functional Endoscopic Sinus Surgery and Septoplasty
    Interventions
    diclofenac; Norco
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-08-01
    Completion
    2020-07-05
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain Control After Functional Endoscopic Sinus Surgery and Septoplasty
    Interventiondiclofenac; Norco
    PhasePhase 4
    Registry statusCompleted