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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocodone Bitartrate

FDA-approved product (capsule, extended release, oral), marketed as Hydrocodone Bitartrate, Hysingla Er, Vantrela Er and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Hydrocodone Bitartrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cough
  • Drug dependence
  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids; Opium alkaloids and derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA44.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae46.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocodone Bitartrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocodone Bitartrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Non-opioid Based Pain Control After Thyroidectomy

    NCT03988075 · start 2018-07-24

    Registered record
    Registry ID
    NCT03988075
    Conditions
    Pain; Thyroidectomy
    Interventions
    Acetaminophen and hydrocodone based pain control; Acetaminophen and ibuprofen based pain control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-07-24
    Completion
    2019-09-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Thyroidectomy
    InterventionAcetaminophen and hydrocodone based pain control; Acetaminophen and ibuprofen based pain control
    PhaseNot applicable
    Registry statusCompleted

  • Multimodal Analgesia in Shoulder Arthroplasty

    NCT03586934 · start 2018-06-01

    Registered record
    Registry ID
    NCT03586934
    Conditions
    Shoulder Pain; Opioid Use
    Interventions
    Acetaminophen; Celecoxib 200mg; Celecoxib 400 mg; Ropivacaine; Ketorolac; Acetaminophen Injectable Product; Oxycodone; Tramadol; Morphine Injectable Solution; hydrocodone bitartrate and acetaminophen; Morphine; Oxycodone Hydrochloride; Meloxicam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2018-06-01
    Completion
    2019-06-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Pain; Opioid Use
    InterventionAcetaminophen; Celecoxib 200mg; Celecoxib 400 mg; Ropivacaine +9 more
    PhasePhase 3
    Registry statusWithdrawn

  • MAST Trial: Multi-modal Analgesic Strategies in Trauma

    NCT03472469 · start 2018-04-02

    Registered record
    Registry ID
    NCT03472469
    Conditions
    Nonspecific Pain Post Traumatic Injury
    Interventions
    Acetaminophen IV/PO; Acetaminophen PO; Ketorolac; Celebrex; Naproxen; Tramadol; Pregabalin; Gabapentin; Lidocaine; Opioids; Regional anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-04-02
    Completion
    2019-07-03
    Enrolment
    1,561

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNonspecific Pain Post Traumatic Injury
    InterventionAcetaminophen IV/PO; Acetaminophen PO; Ketorolac; Celebrex +7 more
    PhasePhase 4
    Registry statusCompleted

  • Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section

    NCT03372382 · start 2017-12-13

    Registered record
    Registry ID
    NCT03372382
    Conditions
    Opioid Use; Pain, Postoperative
    Interventions
    Ibuprofen; Acetaminophen; Norco
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-12-13
    Completion
    2018-04-10
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use; Pain, Postoperative
    InterventionIbuprofen; Acetaminophen; Norco
    PhasePhase 4
    Registry statusCompleted

  • Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED)

    NCT03173456 · start 2017-11-28

    Registered record
    Registry ID
    NCT03173456
    Conditions
    Musculoskeletal Pain
    Interventions
    oxycodone/APAP; hydrocodone/APAP; codeine/APAP; 400 ibuprofen/APAP; 800 ibuprofen/APAP
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-11-28
    Completion
    2019-11-14
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMusculoskeletal Pain
    Interventionoxycodone/APAP; hydrocodone/APAP; codeine/APAP; 400 ibuprofen/APAP +1 more
    PhasePhase 2
    Registry statusCompleted

  • Pain Management in Head and Neck Surgery Patients

    NCT03121963 · start 2017-11-10

    Registered record
    Registry ID
    NCT03121963
    Conditions
    Pain Management
    Interventions
    Oxycodone; Acetaminophen; Gabapentin; Celecoxib; Hydrocodone-Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-11-10
    Completion
    2021-11-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain Management
    InterventionOxycodone; Acetaminophen; Gabapentin; Celecoxib +1 more
    PhasePhase 4
    Registry statusWithdrawn

  • A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults

    NCT03137030 · start 2017-09

    Registered record
    Registry ID
    NCT03137030
    Conditions
    Opioid-Related Disorders; Pain, Acute; Pain, Postoperative
    Interventions
    GRT7014 - Abuse Deterrend Tablet; Norco 5Mg-325Mg Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2017-09
    Completion
    2018-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid-Related Disorders; Pain, Acute; Pain, Postoperative
    InterventionGRT7014 - Abuse Deterrend Tablet; Norco 5Mg-325Mg Tablet
    PhasePhase 1
    Registry statusWithdrawn

  • Bandage Contact Lenses for Corneal Abrasions

    NCT03206723 · start 2017-07-01

    Registered record
    Registry ID
    NCT03206723
    Conditions
    Corneal Abrasion; Eye Trauma
    Interventions
    Bandage contact lens; Eyedrop; Hydrocodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-07-01
    Completion
    2019-03-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorneal Abrasion; Eye Trauma
    InterventionBandage contact lens; Eyedrop; Hydrocodone
    PhasePhase 2
    Registry statusUnknown

  • A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy

    NCT03206749 · start 2017-06-29

    Registered record
    Registry ID
    NCT03206749
    Conditions
    Acute Pain
    Interventions
    VX-150; HB/APAP; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-06-29
    Completion
    2017-12-08
    Enrolment
    243

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    InterventionVX-150; HB/APAP; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

    NCT02958566 · start 2017-01

    Registered record
    Registry ID
    NCT02958566
    Conditions
    Colon Cancer; Colon Diverticulosis; Colonic Neoplasms; Colonic Diverticulitis; Pain, Postoperative; Ileus; Ileus Paralytic; Ileus; Mechanical; Constipation Drug Induced; Constipation; Rectum Cancer; Rectum Neoplasm
    Interventions
    Acetaminophen; Gabapentin; Orphenadrine; Lidocaine; Marcaine; Ketamine; Methadone; Tramadol; Ketorolac; Morphine Sulfate; Fentanyl; Dilaudid; Hydrocodone-Acetaminophen Tab 5-325 MG; Morphine Sulfate; Fentanyl; Dilaudid; HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-01
    Completion
    2018-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColon Cancer; Colon Diverticulosis; Colonic Neoplasms; Colonic Diverticulitis +9 more
    InterventionAcetaminophen; Gabapentin; Orphenadrine; Lidocaine +13 more
    PhasePhase 4
    Registry statusUnknown

  • Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

    NCT02625181 · start 2016-07

    Registered record
    Registry ID
    NCT02625181
    Conditions
    Postoperative Nausea and Vomiting
    Interventions
    Automated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery; Anesthesia Information Management System (AIMS); Perioperative Data Warehouse (PDW); General anesthesia; Elective surgery; Propofol; Sevoflurane; Isoflurane; Desflurane; Scopolamine; Droperidol; Haloperidol; Dexamethasone; Promethazine; Meclizine; Aprepitant; Metoclopramide; Fentanyl; Sufentanil; Alfentanil; Remifentanil; Morphine; Meperidine; Hydromorphone; Methadone; Oxycodone; Oxymorphone; Hydrocodone; Ketamine; Ondansetron; Granisetron; Dolasetron mesylate; Palonosetron; Tropisetron; Ramosetron
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-07
    Completion
    2017-11-30
    Enrolment
    27,034

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Nausea and Vomiting
    InterventionAutomated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery +34 more
    PhaseNot applicable
    Registry statusCompleted

  • Study to Evaluate the Analgesic Efficacy and Safety of Hydrocodone Bitartrate/Acetaminophen Immediate-Release Tablets in Participants With Moderate to Severe Pain Following Bunionectomy

    NCT02487108 · start 2015-08-11

    Registered record
    Registry ID
    NCT02487108
    Conditions
    Pain
    Interventions
    TV-46763; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-08-11
    Completion
    2016-03-30
    Enrolment
    569

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionTV-46763; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy

    NCT02480114 · start 2015-07

    Registered record
    Registry ID
    NCT02480114
    Conditions
    Malignant Head and Neck Neoplasm; Mucositis; Radiation-Induced Disorder
    Interventions
    Educational Intervention; Gabapentin; Pain Therapy; Quality-of-Life Assessment; Questionnaire Administration; Oxycodone/Acetaminophen; Hydrocodone/Acetaminophen; Fentanyl; Ibuprofen; Magic Mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-07
    Completion
    2020-01
    Enrolment
    79

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalignant Head and Neck Neoplasm; Mucositis; Radiation-Induced Disorder
    InterventionEducational Intervention; Gabapentin; Pain Therapy; Quality-of-Life Assessment +6 more
    PhasePhase 3
    Registry statusCompleted

  • Post-operative Analgesia in Elective, Soft-tissue Hand Surgery

    NCT02029235 · start 2015-02-10

    Registered record
    Registry ID
    NCT02029235
    Conditions
    Carpal Tunnel; Ganglion Cyst; Trigger Finger; De Quervain Disease
    Interventions
    Acetaminophen/Ibuprofen; Acetaminophen/Hydrocodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2015-02-10
    Completion
    2018-06-30
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel; Ganglion Cyst; Trigger Finger; De Quervain Disease
    InterventionAcetaminophen/Ibuprofen; Acetaminophen/Hydrocodone
    PhasePhase 4
    Registry statusTerminated

  • The Effect of NSAIDs After a Rotator Cuff Repair Surgery.

    NCT02153177 · start 2015-01

    Registered record
    Registry ID
    NCT02153177
    Conditions
    Rotator Cuff Tear
    Interventions
    Rotator cuff repair; Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole; Hydrocodone/Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2015-01
    Completion
    2018-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear
    InterventionRotator cuff repair; Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole; Hydrocodone/Acetaminophen
    PhasePhase 4
    Registry statusWithdrawn