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AMR Drug RepurposingSmart Screeningresearch prototype

Valdecoxib

FDA-approved product (tablet, oral), marketed as Bextra.

Registered studies
31
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Valdecoxib
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Dysmenorrhea
  • Osteoarthritis
  • Rheumatic disease
  • Rheumatoid arthritis

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Coxibs
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli16.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

31registered studies name this medicine, for any condition. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Valdecoxib in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Valdecoxib with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Double-blind, Double-dummy, Multicenter, Randomized Study of the Efficacy and Tolerability of Valdecoxib 40 mg Versus Rofecoxib 50 mg in Treating the Symptoms of Ankle Sprain

    NCT00657449 · start 2003-06-04

    Registered record
    Registry ID
    NCT00657449
    Conditions
    Acute Pain
    Interventions
    valdecoxib; rofecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2003-06-04
    Completion
    2004-10-05
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain
    Interventionvaldecoxib; rofecoxib
    PhasePhase 4
    Registry statusTerminated

  • A Dose-Ranging Study Of Valdecoxib 5 Mg, 10 Mg, And 20 Mg Once Daily Versus Placebo In Patients With Osteoarthritis Of The Knee (Japan)

    NCT00650624 · start 2003-06

    Registered record
    Registry ID
    NCT00650624
    Conditions
    Osteoarthritis, Knee
    Interventions
    valdecoxib; valdecoxib; valdecoxib; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-06
    Completion
    2004-01
    Enrolment
    416

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    Interventionvaldecoxib; valdecoxib; valdecoxib; placebo
    PhasePhase 2
    Registry statusCompleted

  • A Study of the Recovery Benefits After Treatment With Parecoxib/Valdecoxib in Patients Undergoing Abdominal Surgery

    NCT00651300 · start 2003-04

    Registered record
    Registry ID
    NCT00651300
    Conditions
    Pain
    Interventions
    Parecoxib/Valdecoxib; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2003-04
    Completion
    2004-03
    Enrolment
    91

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionParecoxib/Valdecoxib; Placebo
    PhasePhase 3
    Registry statusTerminated

  • A Comparison Of Valdecoxib 20 Mg Twice Daily and 40 Mg Daily and Placebo In The Treatment Of Sore Throat

    NCT00647829 · start 2003-02

    Registered record
    Registry ID
    NCT00647829
    Conditions
    Pharyngitis
    Interventions
    valdecoxib; valdecoxib; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-02
    Completion
    2003-12
    Enrolment
    197

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharyngitis
    Interventionvaldecoxib; valdecoxib; placebo
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients

    NCT00650455 · start 2003-02

    Registered record
    Registry ID
    NCT00650455
    Conditions
    Arthritis, Rheumatoid
    Interventions
    valdecoxib; naproxen; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-02
    Completion
    2005-01
    Enrolment
    489

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Rheumatoid
    Interventionvaldecoxib; naproxen; placebo
    PhasePhase 4
    Registry statusCompleted

  • A Study Comparing the Efficacy and Safety of Valdecoxib Plus Parecoxib Versus Valdecoxib Plus Placebo for the Treatment of Pain After Coronary Artery Bypass Surgery

    NCT00636064 · start 2003-01

    Registered record
    Registry ID
    NCT00636064
    Conditions
    Pain
    Interventions
    Parecoxib Sodium/Valdecoxib; Placebo/Valdecoxib; Placebo/Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-01
    Completion
    2004-01
    Enrolment
    1,671

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionParecoxib Sodium/Valdecoxib; Placebo/Valdecoxib; Placebo/Placebo
    PhasePhase 3
    Registry statusCompleted

  • A Double Blind, Double Dummy, Randomized, Comparative Study Of The Efficacy And Safety Of Valdecoxib 40 Mg Twice Daily, As Needed In The First Menstrual Cycle Day And Then Once A Day, And Piroxicam 40 Mg Once A Day In The Treatment Of Patients With Primary Dysmenorrhea

    NCT00649415 · start 2003-01

    Registered record
    Registry ID
    NCT00649415
    Conditions
    Dysmenorrhea
    Interventions
    piroxicam; valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-01
    Completion
    2003-07
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDysmenorrhea
    Interventionpiroxicam; valdecoxib
    PhasePhase 4
    Registry statusCompleted

  • Analgesic Efficacy Of Valdecoxib In Patients Following Bunion Surgery

    NCT00653354 · start 2002-12

    Registered record
    Registry ID
    NCT00653354
    Conditions
    Pain, Post-surgical
    Interventions
    valdecoxib; valdecoxib/placebo; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-12
    Completion
    2003-03
    Enrolment
    360

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Post-surgical
    Interventionvaldecoxib; valdecoxib/placebo; placebo
    PhasePhase 3
    Registry statusCompleted

  • A Multi-Center, Randomized, Double-Blind, Parallel Group Study To Compare The Efficacy And Tolerability Of Valdecoxib And Diclofenac In Patients With A Sprained Ankle

    NCT00671320 · start 2002-12

    Registered record
    Registry ID
    NCT00671320
    Conditions
    Pain; Sprains and Strains; Sprain
    Interventions
    valdecoxib; diclofenac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-12
    Completion
    2003-10
    Enrolment
    202

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Sprains and Strains; Sprain
    Interventionvaldecoxib; diclofenac
    PhasePhase 4
    Registry statusCompleted

  • Perioperative Inflammation and Cyclooxygenase 2 (COX-2)

    NCT00122096 · start 2002-11

    Registered record
    Registry ID
    NCT00122096
    Conditions
    Neurosurgery; Pain
    Interventions
    valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-11
    Completion
    2006-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeurosurgery; Pain
    Interventionvaldecoxib
    PhasePhase 4
    Registry statusCompleted

  • Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain

    NCT00649610 · start 2002-11

    Registered record
    Registry ID
    NCT00649610
    Conditions
    Low Back Pain
    Interventions
    valdecoxib; diclofenac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-11
    Completion
    2003-05
    Enrolment
    340

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    Interventionvaldecoxib; diclofenac
    PhasePhase 4
    Registry statusCompleted

  • A Randomized, Double-Blind Study of the Efficacy and Safety of Valdecoxib Compared to Placebo for Treatment of Post- Cholecystectomy Surgery Pain

    NCT00661635 · start 2002-11

    Registered record
    Registry ID
    NCT00661635
    Conditions
    Laparoscopic Cholecystectomy; Pain
    Interventions
    placebo; valdecoxib; valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-11
    Completion
    2003-07
    Enrolment
    490

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Cholecystectomy; Pain
    Interventionplacebo; valdecoxib; valdecoxib
    PhasePhase 3
    Registry statusCompleted

  • Analgesic Efficacy And Safety of Valdecoxib For Treatment Of Post-Surgical Pain From Bunionectomy Surgery

    NCT00683137 · start 2002-10

    Registered record
    Registry ID
    NCT00683137
    Conditions
    Pain; Hallux Valgus
    Interventions
    valdecoxib; valdecoxib; valdecoxib/placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-10
    Completion
    2003-02
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Hallux Valgus
    Interventionvaldecoxib; valdecoxib; valdecoxib/placebo
    PhasePhase 3
    Registry statusCompleted

  • A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-190)(COMPLETED)

    NCT00092339 · start 2002-08-01

    Registered record
    Registry ID
    NCT00092339
    Conditions
    Postoperative Pain
    Interventions
    MK0966, rofecoxib; Comparator: valdecoxib, placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-08-01
    Completion
    2002-09-15
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionMK0966, rofecoxib; Comparator: valdecoxib, placebo
    PhasePhase 3
    Registry statusCompleted

  • A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)

    NCT00092300 · start 2002-05

    Registered record
    Registry ID
    NCT00092300
    Conditions
    Postoperative Pain
    Interventions
    MK0966, rofecoxib; Comparator: valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-05
    Completion
    Not recorded
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionMK0966, rofecoxib; Comparator: valdecoxib
    PhasePhase 3
    Registry statusCompleted