Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Valdecoxib

FDA-approved product (tablet, oral), marketed as Bextra.

Registered studies
31
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Valdecoxib
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Dysmenorrhea
  • Osteoarthritis
  • Rheumatic disease
  • Rheumatoid arthritis

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Coxibs
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli16.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae4.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

31registered studies name this medicine, for any condition. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Valdecoxib in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Valdecoxib with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Intravenous Dynastat on Postoperative Sore Throat

    NCT03915561 · start 2019-03-01

    Registered record
    Registry ID
    NCT03915561
    Conditions
    Sore Throat; Postoperative Complications
    Interventions
    Parecoxib Injectable Product; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2019-03-01
    Completion
    2020-11-30
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSore Throat; Postoperative Complications
    InterventionParecoxib Injectable Product; Normal saline
    PhasePhase 2
    Registry statusUnknown

  • Effect Study of Parecoxib to Treat Emergence Delirium and Postoperative Pain

    NCT01221025 · start 2010-09

    Registered record
    Registry ID
    NCT01221025
    Conditions
    Emergence Delirium; Postoperative Pain
    Interventions
    Parecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2010-09
    Completion
    2012-06
    Enrolment
    900

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmergence Delirium; Postoperative Pain
    InterventionParecoxib
    PhasePhase 4
    Registry statusUnknown

  • Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain

    NCT00115752 · start 2005-06-20

    Registered record
    Registry ID
    NCT00115752
    Conditions
    Pain
    Interventions
    Valdecoxib; COX Inhibitor
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-06-20
    Completion
    2006-10-04
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionValdecoxib; COX Inhibitor
    PhasePhase 2
    Registry statusCompleted

  • Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers

    NCT00260325 · start 2004-08

    Registered record
    Registry ID
    NCT00260325
    Conditions
    Pain; Hyperalgesia
    Interventions
    valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-08
    Completion
    2006-04
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Hyperalgesia
    Interventionvaldecoxib
    PhasePhase 4
    Registry statusCompleted

  • Predicting Patients' Response to Spinal Manipulation

    NCT00285649 · start 2004-07

    Registered record
    Registry ID
    NCT00285649
    Conditions
    Low Back Pain
    Interventions
    HVLA-SM; LVVA-SM; Usual Medical Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-07
    Completion
    2007-03
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    InterventionHVLA-SM; LVVA-SM; Usual Medical Care
    PhaseNot applicable
    Registry statusCompleted

  • Elderly Back Pain: Comparing Chiropractic to Medical Care

    NCT00602901 · start 2004-07

    Registered record
    Registry ID
    NCT00602901
    Conditions
    Subacute Low Back Pain; Chronic Low Back Pain
    Interventions
    HVLA-SM; LVVA-SM; Usual medical care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-07
    Completion
    2007-03
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubacute Low Back Pain; Chronic Low Back Pain
    InterventionHVLA-SM; LVVA-SM; Usual medical care
    PhasePhase 2
    Registry statusCompleted

  • A Multicenter, Open Label Trial To Evaluate Pain Relief With Intravenous Followed By Oral Therapy With Parecoxib/Valdecoxib 40 Mg/Day For Treatment Of Post-Laparoscopic Surgery Pain

    NCT00660855 · start 2004-06

    Registered record
    Registry ID
    NCT00660855
    Conditions
    Pain, Post Surgical
    Interventions
    parecoxib/valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2004-06
    Completion
    2004-07
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Post Surgical
    Interventionparecoxib/valdecoxib
    PhasePhase 4
    Registry statusTerminated

  • Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee

    NCT00652808 · start 2004-05

    Registered record
    Registry ID
    NCT00652808
    Conditions
    Osteoarthritis; Knee
    Interventions
    valdecoxib; naproxen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-05
    Completion
    2004-09
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Knee
    Interventionvaldecoxib; naproxen
    PhasePhase 3
    Registry statusCompleted

  • Double-Blind, Randomized Study Of The Analgesic Efficacy And Safety Of Valdecoxib 20 Mg Daily And Valdecoxib 20 Mg Twice Daily Compared To Placebo For Management Of Acute Postsurgical Pain In Anterior Cruciate Ligament (ACL) Reconstruction

    NCT00650039 · start 2004-03

    Registered record
    Registry ID
    NCT00650039
    Conditions
    Pain
    Interventions
    placebo; valdecoxib; valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03
    Completion
    2005-02
    Enrolment
    488

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    Interventionplacebo; valdecoxib; valdecoxib
    PhasePhase 3
    Registry statusCompleted

  • A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction

    NCT00650598 · start 2004-03

    Registered record
    Registry ID
    NCT00650598
    Conditions
    Pain, Postoperative
    Interventions
    valdecoxib; diclofenac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-03
    Completion
    2004-08
    Enrolment
    328

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    Interventionvaldecoxib; diclofenac
    PhasePhase 4
    Registry statusCompleted

  • NSAIDs With Morphine-PCA Compared to Epidural Analgesia in Thoracotomy Pain

    NCT01541137 · start 2004-03

    Registered record
    Registry ID
    NCT01541137
    Conditions
    Postoperative Pain
    Interventions
    Diclofenac; parecoxib/ valdecoxib; patient controlled epidural analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-03
    Completion
    2008-09
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionDiclofenac; parecoxib/ valdecoxib; patient controlled epidural analgesia
    PhaseNot applicable
    Registry statusCompleted

  • Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages

    NCT00763997 · start 2004-02

    Registered record
    Registry ID
    NCT00763997
    Conditions
    Platelet Aggregation
    Interventions
    dipyrone; Ibuprofen; Acetaminophen; Acetaminophen; Parecoxib/Valdecoxib; Blood samples
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-02
    Completion
    2004-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlatelet Aggregation
    Interventiondipyrone; Ibuprofen; Acetaminophen; Acetaminophen +2 more
    PhaseNot applicable
    Registry statusCompleted

  • COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined

    NCT01361789 · start 2004-01

    Registered record
    Registry ID
    NCT01361789
    Conditions
    Rupture of Anterior Cruciate Ligament
    Interventions
    parecoxib, valdecoxib, etoricoxib; Dexamethasone; parecoxib, valdecoxib, parecoxib and dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01
    Completion
    2009-12
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRupture of Anterior Cruciate Ligament
    Interventionparecoxib, valdecoxib, etoricoxib; Dexamethasone; parecoxib, valdecoxib, parecoxib and dexamethasone
    PhasePhase 4
    Registry statusCompleted

  • Efficacy Study of Glyceryl-Trinitrate Patch and Parecoxib (Valdecoxib) for the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography (ERCP)

    NCT00419549 · start 2003-10

    Registered record
    Registry ID
    NCT00419549
    Conditions
    ERCP; Pancreatitis
    Interventions
    Glyceryl - trinitrate; Valdecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2003-10
    Completion
    2005-09
    Enrolment
    371

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionERCP; Pancreatitis
    InterventionGlyceryl - trinitrate; Valdecoxib
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • A Double-Blind, Double Dummy, Randomized Comparison Study Of The Efficacy And Safety Of Valdecoxib 10mg Once Daily And Naproxen 500mg Twice Daily In Treating The Signs And Symptoms Of Osteoarthritis Of The Knee Or Hip In Taiwan

    NCT00648258 · start 2003-07

    Registered record
    Registry ID
    NCT00648258
    Conditions
    Osteoarthritis
    Interventions
    valdecoxib; naproxen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-07
    Completion
    2004-04
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    Interventionvaldecoxib; naproxen
    PhasePhase 3
    Registry statusCompleted