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AMR Drug RepurposingSmart Screeningresearch prototype

Quinine Sulfate

FDA-approved product (capsule, oral), marketed as Qualaquin, Quinine Sulfate.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Quinine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Malaria
  • Muscle cramp
  • Plasmodium falciparum malaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Quinine and derivatives; Methanolquinolines
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01BC01

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis13.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 0 of 1 lab record
Open Quinine Sulfate in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quinine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Cohort Event Monitoring in Sub Saharan Africa

    NCT02817919 · start 2016-05

    Registered record
    Registry ID
    NCT02817919
    Conditions
    Malaria
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-05
    Completion
    2017-03
    Enrolment
    1,126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Validation of Aspiration Markers in Intubated Patients

    NCT02598713 · start 2015-12

    Registered record
    Registry ID
    NCT02598713
    Conditions
    Pneumonia; Aspiration
    Interventions
    Aspiration Marker
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2015-12
    Completion
    2024-06-30
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Aspiration
    InterventionAspiration Marker
    PhasePhase 1
    Registry statusWithdrawn

  • Quantitative Evaluation of Bitter Taste in Obesity

    NCT03149666 · start 2015-02-01

    Registered record
    Registry ID
    NCT03149666
    Conditions
    Obesity
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-02-01
    Completion
    2016-07-01
    Enrolment
    262

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of a Compliance Marker in Prescription Opioid Abusers With Chronic Pain

    NCT02276989 · start 2014-12

    Registered record
    Registry ID
    NCT02276989
    Conditions
    Compliance; Chronic Pain
    Interventions
    acetazolamide; Quinine; Riboflavin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2014-12
    Completion
    2016-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCompliance; Chronic Pain
    Interventionacetazolamide; Quinine; Riboflavin
    PhasePhase 2
    Registry statusWithdrawn

  • Sorting of Oral Sensations

    NCT02390180 · start 2014-10

    Registered record
    Registry ID
    NCT02390180
    Conditions
    Taste Qualities; Primary Tastes
    Interventions
    Tasting solutions
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-10
    Completion
    2015-03
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTaste Qualities; Primary Tastes
    InterventionTasting solutions
    PhaseNot recorded
    Registry statusCompleted

  • Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With Malaria

    NCT02092766 · start 2014-06

    Registered record
    Registry ID
    NCT02092766
    Conditions
    Anaemia
    Interventions
    artesunate; quinine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-06
    Completion
    2015-04
    Enrolment
    217

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnaemia
    Interventionartesunate; quinine
    PhasePhase 4
    Registry statusCompleted

  • A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon

    NCT02563704 · start 2013-09

    Registered record
    Registry ID
    NCT02563704
    Conditions
    Malaria
    Interventions
    Artesunate; Quinine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-09
    Completion
    2014-03
    Enrolment
    238

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtesunate; Quinine
    PhasePhase 3
    Registry statusCompleted

  • Malaria Treatment With Injectable ArteSunate

    NCT01828333 · start 2013-04

    Registered record
    Registry ID
    NCT01828333
    Conditions
    Severe Malaria
    Interventions
    No intervention
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-04
    Completion
    2013-06
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Malaria
    InterventionNo intervention
    PhaseNot recorded
    Registry statusCompleted

  • Taste Physiology in Healthy, Normal-weight Volunteers

    NCT02255812 · start 2013-03

    Registered record
    Registry ID
    NCT02255812
    Conditions
    Exploratory Behavior
    Interventions
    Single intragastric instillation of 200 mL tap water via nasogastric tube; Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube; Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube; Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube; Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube; Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-03
    Completion
    2013-10
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExploratory Behavior
    InterventionSingle intragastric instillation of 200 mL tap water via nasogastric tube; Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube; Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube; Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

    NCT01851473 · start 2012-10-24

    Registered record
    Registry ID
    NCT01851473
    Conditions
    Cocaine Use; Pharmacokinetics
    Interventions
    cocaine; quinine; acetazolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-10-24
    Completion
    2015-10-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Use; Pharmacokinetics
    Interventioncocaine; quinine; acetazolamide
    PhasePhase 1
    Registry statusCompleted

  • Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)

    NCT01594827 · start 2012-10

    Registered record
    Registry ID
    NCT01594827
    Conditions
    Cystic Fibrosis
    Interventions
    Inhaled Vancomycin; Placebo (Sterile Water); Rifampin; Trimethoprim/Sulfamethoxazole (TMP/SMX); Doxycycline; Mupirocin Intranasal Creme; 4% chlorhexidine gluconate liquid skin cleanser
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-10
    Completion
    2017-12-30
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis
    InterventionInhaled Vancomycin; Placebo (Sterile Water); Rifampin; Trimethoprim/Sulfamethoxazole (TMP/SMX) +3 more
    PhasePhase 2
    Registry statusCompleted

  • Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria

    NCT01374581 · start 2012-05

    Registered record
    Registry ID
    NCT01374581
    Conditions
    Malaria
    Interventions
    Artemether/Lumefantrine; Artesunate/Amodiaquine; Quinine + Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-05
    Completion
    2014-06
    Enrolment
    2,117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtemether/Lumefantrine; Artesunate/Amodiaquine; Quinine + Clindamycin
    PhasePhase 3
    Registry statusCompleted

  • The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake

    NCT02759926 · start 2011-08

    Registered record
    Registry ID
    NCT02759926
    Conditions
    Healthy; Obesity
    Interventions
    Denatonium benzoate; Quinine hydrochloride; Tap water
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2011-08
    Completion
    Not recorded
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Obesity
    InterventionDenatonium benzoate; Quinine hydrochloride; Tap water
    PhaseNot applicable
    Registry statusUnknown

  • Superiority of ArTiMist Versus Quinine in Children With Severe Malaria

    NCT01258049 · start 2010-12

    Registered record
    Registry ID
    NCT01258049
    Conditions
    Plasmodium Falciparum Malaria
    Interventions
    Artemether Sublingual Spray; Quinine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-12
    Completion
    2012-09
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlasmodium Falciparum Malaria
    InterventionArtemether Sublingual Spray; Quinine
    PhasePhase 3
    Registry statusCompleted

  • Artemether-Lumefantrine Effectiveness in Guinea-Bissau

    NCT01157689 · start 2010-03

    Registered record
    Registry ID
    NCT01157689
    Conditions
    Malaria
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-03
    Completion
    2016-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted