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AMR Drug RepurposingSmart Screeningresearch prototype

Quinine Sulfate

FDA-approved product (capsule, oral), marketed as Qualaquin, Quinine Sulfate.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Quinine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Malaria
  • Muscle cramp
  • Plasmodium falciparum malaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Quinine and derivatives; Methanolquinolines
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01BC01

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis13.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 0 of 1 lab record
Open Quinine Sulfate in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quinine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities

    NCT07572396 · start 2026-04-30

    Registered record
    Registry ID
    NCT07572396
    Conditions
    High-risk HPV (Any Strain); LSIL, Low Grade Squamous Intraepithelial Lesion; ASC-US; HPV Infection; Cervical Abnormalities; Uterine Cervical Dysplasia
    Interventions
    EGCG and Quinine Sulfate Vaginal Suppository; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-04-30
    Completion
    2027-01-27
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh-risk HPV (Any Strain); LSIL, Low Grade Squamous Intraepithelial Lesion; ASC-US; HPV Infection +2 more
    InterventionEGCG and Quinine Sulfate Vaginal Suppository; Placebo
    PhasePhase 2
    Registry statusRecruiting

  • Safety of Antimalarials in the FIRst trimEster

    NCT06962319 · start 2025-09-30

    Registered record
    Registry ID
    NCT06962319
    Conditions
    Malaria, Pregnancy; Malaria, Antepartum; Malaria (Uncomplicated)
    Interventions
    dihydroartemisinin-piperaquine (DP); Pyronaridine-artesunate (PA); Artemether-lumefantrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-09-30
    Completion
    2029-08
    Enrolment
    1,510

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria, Pregnancy; Malaria, Antepartum; Malaria (Uncomplicated)
    Interventiondihydroartemisinin-piperaquine (DP); Pyronaridine-artesunate (PA); Artemether-lumefantrine
    PhasePhase 3
    Registry statusRecruiting

  • Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic Control

    NCT05682339 · start 2023-06-19

    Registered record
    Registry ID
    NCT05682339
    Conditions
    Healthy
    Interventions
    Quinine; L-isoleucine; Combination of quinine and L-isoleucine; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-19
    Completion
    2024-06-24
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinine; L-isoleucine; Combination of quinine and L-isoleucine; Control
    PhaseNot applicable
    Registry statusCompleted

  • Studies on the Impact of Taste-aware Intelligent Analysis of Oral Nutritional Supplements

    NCT05651321 · start 2023-04

    Registered record
    Registry ID
    NCT05651321
    Conditions
    Cancer- and Cancer Treatment-Related Conditions; Stroke
    Interventions
    Samples materials of basic taste stimuli and enteral nutrition preparations
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-04
    Completion
    2024-12
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer- and Cancer Treatment-Related Conditions; Stroke
    InterventionSamples materials of basic taste stimuli and enteral nutrition preparations
    PhaseNot recorded
    Registry statusUnknown

  • Efficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative Study

    NCT06472258 · start 2023-03-01

    Registered record
    Registry ID
    NCT06472258
    Conditions
    Malaria
    Interventions
    IV Artesunate; IV Quinine Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-01
    Completion
    2023-06-30
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionIV Artesunate; IV Quinine Hydrochloride
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic Control

    NCT05720390 · start 2023-02-02

    Registered record
    Registry ID
    NCT05720390
    Conditions
    Healthy
    Interventions
    Quinine; L-leucine; Combination of quinine and L-leucine; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-02-02
    Completion
    2024-04-09
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinine; L-leucine; Combination of quinine and L-leucine; Control
    PhaseNot applicable
    Registry statusCompleted

  • Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 )

    NCT05808231 · start 2021-04-26

    Registered record
    Registry ID
    NCT05808231
    Conditions
    COVID-19
    Interventions
    Standard of Care + Quinine Sulfate; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-04-26
    Completion
    2023-05-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19
    InterventionStandard of Care + Quinine Sulfate; Standard of Care
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide Release

    NCT04873011 · start 2020-10-29

    Registered record
    Registry ID
    NCT04873011
    Conditions
    Obesity
    Interventions
    Quinine Hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2020-10-29
    Completion
    2025-10-29
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionQuinine Hydrochloride; Placebo
    PhasePhase 1
    Registry statusUnknown

  • Evaluation of Targeted Mass Drug Administration for Malaria in Ethiopia

    NCT04241705 · start 2020-01-20

    Registered record
    Registry ID
    NCT04241705
    Conditions
    Malaria
    Interventions
    Treatment of positive individuals per national treatment guidelines; Presumptive treatment with artemether-lumefantrine (AL) plus 14 days of primaquine (PQ); Optimized malaria control interventions
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-01-20
    Completion
    2022-01-20
    Enrolment
    48,960

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionTreatment of positive individuals per national treatment guidelines; Presumptive treatment with artemether-lumefantrine (AL) plus 14 days of primaquine (PQ); Optimized malaria control interventions
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Hydroxychloroquine Sulphate in Healthy Lean Females

    NCT04005768 · start 2019-08-01

    Registered record
    Registry ID
    NCT04005768
    Conditions
    Obesity
    Interventions
    Hydroxychloroquine Sulphate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-08-01
    Completion
    2019-10-01
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionHydroxychloroquine Sulphate; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Quinine and Food Intake

    NCT03565133 · start 2018-08-17

    Registered record
    Registry ID
    NCT03565133
    Conditions
    Obesity
    Interventions
    Quinine sham feeding quinine; Gastric quinine; Oral sham feeding placebo; Gastric placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-08-17
    Completion
    2019-08-15
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionQuinine sham feeding quinine; Gastric quinine; Oral sham feeding placebo; Gastric placebo
    PhaseNot applicable
    Registry statusCompleted

  • Nutrition Intervention to Promote Immune Recovery From Sleep Restriction

    NCT03525184 · start 2018-02-12

    Registered record
    Registry ID
    NCT03525184
    Conditions
    Sleep Restriction
    Interventions
    Additional protein and multi-nutrient beverage; Placebo beverage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-02-12
    Completion
    2019-12-10
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Restriction
    InterventionAdditional protein and multi-nutrient beverage; Placebo beverage
    PhaseNot applicable
    Registry statusCompleted

  • Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation

    NCT03276481 · start 2017-08-28

    Registered record
    Registry ID
    NCT03276481
    Conditions
    Multiple Myeloma
    Interventions
    Oral microbiota assessment; Comprehensive chemical gustometry; Measurement of salivary flow; Surveys assessing taste disturbances
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-08-28
    Completion
    2023-07-12
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma
    InterventionOral microbiota assessment; Comprehensive chemical gustometry; Measurement of salivary flow; Surveys assessing taste disturbances
    PhaseNot recorded
    Registry statusCompleted

  • IG vs ID Bitter Administration

    NCT03985865 · start 2017-03-02

    Registered record
    Registry ID
    NCT03985865
    Conditions
    Obesity
    Interventions
    Intragastric quinine hydrochloride; Intragastric denatonium benzoate; Intragastric placebo; Intraduodenal quinine hydrochloride; Intraduodenal denatonium benzoate; Intraduodenal placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-03-02
    Completion
    2018-05-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionIntragastric quinine hydrochloride; Intragastric denatonium benzoate; Intragastric placebo; Intraduodenal quinine hydrochloride +2 more
    PhasePhase 4
    Registry statusCompleted

  • Routine Antenatal Care Versus Screening and Treatment of Malaria in Pregnancy in Rwanda

    NCT03508349 · start 2016-09-05

    Registered record
    Registry ID
    NCT03508349
    Conditions
    Malaria in Pregnancy
    Interventions
    IST
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-09-05
    Completion
    2019-03-18
    Enrolment
    1,786

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria in Pregnancy
    InterventionIST
    PhaseNot applicable
    Registry statusCompleted