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AMR Drug RepurposingSmart Screeningresearch prototype

Quinine Sulfate

FDA-approved product (capsule, oral), marketed as Qualaquin, Quinine Sulfate.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Quinine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Malaria
  • Muscle cramp
  • Plasmodium falciparum malaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Quinine and derivatives; Methanolquinolines
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01BC01

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis13.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 0 of 1 lab record
Open Quinine Sulfate in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quinine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of ArTiMist™ in Children

    NCT01047436 · start 2009-12

    Registered record
    Registry ID
    NCT01047436
    Conditions
    Falciparum Malaria
    Interventions
    Quinine; Artemether
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-12
    Completion
    2010-01
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFalciparum Malaria
    InterventionQuinine; Artemether
    PhasePhase 2
    Registry statusCompleted

  • Safety and Pharmacokinetics of Quinidine Alone and in Combination With Dabigatran Etexilate

    NCT02171624 · start 2009-03

    Registered record
    Registry ID
    NCT02171624
    Conditions
    Healthy
    Interventions
    dabigatran etexilate; quinidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-03
    Completion
    Not recorded
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventiondabigatran etexilate; quinidine
    PhasePhase 1
    Registry statusCompleted

  • Drug-Drug Interaction Study Between Quinine Sulfate and Rosiglitazone

    NCT00785213 · start 2008-09

    Registered record
    Registry ID
    NCT00785213
    Conditions
    Healthy
    Interventions
    Rosiglitazone 4 mg Tablets; Rosiglitazone 4 mg Tablets; Quinine Sulfate 324 mg Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-10
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionRosiglitazone 4 mg Tablets; Rosiglitazone 4 mg Tablets; Quinine Sulfate 324 mg Capsules
    PhasePhase 1
    Registry statusCompleted

  • Drug - Drug Interaction Study of Quinine Sulfate and Ciprofloxacin

    NCT00785980 · start 2008-09

    Registered record
    Registry ID
    NCT00785980
    Conditions
    Healthy
    Interventions
    Quinine Sulfate Capsules 324 mg; Ciprofloxacin 500 mg; Quinine Sulfate Capsules 324 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-10
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinine Sulfate Capsules 324 mg; Ciprofloxacin 500 mg; Quinine Sulfate Capsules 324 mg
    PhasePhase 1
    Registry statusCompleted

  • Artemisinin Resistance in Bangladesh

    NCT00639873 · start 2008-06

    Registered record
    Registry ID
    NCT00639873
    Conditions
    Malaria
    Interventions
    Artesunate; quinine-doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-06
    Completion
    2009-11
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtesunate; quinine-doxycycline
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis

    NCT00613743 · start 2007-12

    Registered record
    Registry ID
    NCT00613743
    Conditions
    Cancer; Mucositis
    Interventions
    mouth wash with morphine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-12
    Completion
    2008-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer; Mucositis
    Interventionmouth wash with morphine; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal Impairment

    NCT00785551 · start 2007-11

    Registered record
    Registry ID
    NCT00785551
    Conditions
    Healthy; Renal Impairment
    Interventions
    quinine sulfate; quinine sulfate; quinine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2007-11
    Completion
    2011-01
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Renal Impairment
    Interventionquinine sulfate; quinine sulfate; quinine sulfate
    PhasePhase 1
    Registry statusTerminated

  • Randomized Trial of Erythropoietin During Cerebral Malaria

    NCT00697164 · start 2007-10

    Registered record
    Registry ID
    NCT00697164
    Conditions
    Cerebral Malaria
    Interventions
    Placebo; Erythropoietin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2007-10
    Completion
    2009-03
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCerebral Malaria
    InterventionPlacebo; Erythropoietin
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Effectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan Children

    NCT00540202 · start 2007-09

    Registered record
    Registry ID
    NCT00540202
    Conditions
    Uncomplicated Malaria
    Interventions
    artemether-lumefantrine; Oral quinine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-09
    Completion
    2008-04
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUncomplicated Malaria
    Interventionartemether-lumefantrine; Oral quinine
    PhasePhase 4
    Registry statusUnknown

  • Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline

    NCT00779259 · start 2007-08

    Registered record
    Registry ID
    NCT00779259
    Conditions
    Pharmacokinetics
    Interventions
    Theophylline 300mg; Quinine 648 mg; Theophylline 300 mg; Quinine 648 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-08
    Completion
    2007-09
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics
    InterventionTheophylline 300mg; Quinine 648 mg; Theophylline 300 mg; Quinine 648 mg
    PhasePhase 1
    Registry statusCompleted

  • Comparison Bioavailability Study of Quinine Sulfate in Chocolate Pudding

    NCT00806078 · start 2007-07

    Registered record
    Registry ID
    NCT00806078
    Conditions
    Healthy
    Interventions
    quinine sulfate; quinine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-07
    Completion
    2007-08
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionquinine sulfate; quinine sulfate
    PhasePhase 1
    Registry statusCompleted

  • Drug-Drug Interaction Study of Qualaquin and Midazolam

    NCT00785486 · start 2007-03

    Registered record
    Registry ID
    NCT00785486
    Conditions
    Healthy
    Interventions
    Midazolam Alone; Qualaquin (quinine) alone steady state; Midazolam and Qualaquin at steady state
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-03
    Completion
    2007-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionMidazolam Alone; Qualaquin (quinine) alone steady state; Midazolam and Qualaquin at steady state
    PhasePhase 1
    Registry statusCompleted

  • Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During Pregnancy

    NCT00495508 · start 2006-10

    Registered record
    Registry ID
    NCT00495508
    Conditions
    Malaria
    Interventions
    Quinine; artemether / lumefantrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10
    Completion
    2009-06
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionQuinine; artemether / lumefantrine
    PhasePhase 4
    Registry statusCompleted

  • Investigation of the Efficacy of Quinine Sulphate Administered Via Taste-Masked Pellets to Children With Falciparum Malaria

    NCT00329134 · start 2006-07

    Registered record
    Registry ID
    NCT00329134
    Conditions
    Malaria
    Interventions
    Administration of quinine sulphate taste-masked pellets
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-05
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionAdministration of quinine sulphate taste-masked pellets
    PhasePhase 2
    Registry statusCompleted

  • A Dose Proportionality Study of Quinine Sulfate Capsules Under Fasting Conditions

    NCT00726895 · start 2004-05

    Registered record
    Registry ID
    NCT00726895
    Conditions
    Healthy
    Interventions
    Quinine Sulfate Capsules 324 mg; Quinine Sulfate Capsules 324 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-05
    Completion
    2004-06
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionQuinine Sulfate Capsules 324 mg; Quinine Sulfate Capsules 324 mg
    PhasePhase 1
    Registry statusCompleted