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AMR Drug RepurposingSmart Screeningresearch prototype

Cloxacillin Sodium

FDA-approved product (for solution, oral), marketed as Cloxacillin Sodium, Cloxapen, Tegopen.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Cloxacillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Beta-lactamase resistant penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CF02

Repurposing investigation

Cloxacillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA20.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae69.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 1 of 1 lab record
Open Cloxacillin Sodium in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cloxacillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Ceftriaxone as Home IV for Staph Infections

    NCT04141787 · start 2019-07-11

    Registered record
    Registry ID
    NCT04141787
    Conditions
    Staphylococcal Infections; Osteomyelitis; CNS Infection; Septic Arthritis; Diabetic Foot Infection; Vertebral Osteomyelitis; Abscess; Coagulase Negative Staphylococcal Infection
    Interventions
    Ceftriaxone; Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-07-11
    Completion
    2024-03-30
    Enrolment
    310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Infections; Osteomyelitis; CNS Infection; Septic Arthritis +4 more
    InterventionCeftriaxone; Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
    PhasePhase 4
    Registry statusUnknown

  • Penicillin Against Flucloxacillin Treatment Evaluation

    NCT03632642 · start 2019-07-01

    Registered record
    Registry ID
    NCT03632642
    Conditions
    Staphylococcus Aureus
    Interventions
    Benzylpenicillin; Flucloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2019-07-01
    Completion
    2020-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionBenzylpenicillin; Flucloxacillin
    PhasePhase 4
    Registry statusWithdrawn

  • Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin

    NCT03246360 · start 2017-11-23

    Registered record
    Registry ID
    NCT03246360
    Conditions
    Infection; Methicillin Susceptible Staphylococcus Aureus Infection; Cloxacillin Treatment
    Interventions
    Modification for administration mode of cloxacillin antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-11-23
    Completion
    2018-09-18
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Methicillin Susceptible Staphylococcus Aureus Infection; Cloxacillin Treatment
    InterventionModification for administration mode of cloxacillin antibiotic
    PhaseNot applicable
    Registry statusCompleted

  • Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia

    NCT03108690 · start 2017-10-01

    Registered record
    Registry ID
    NCT03108690
    Conditions
    Bacteremia
    Interventions
    Continuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-10-01
    Completion
    2023-03-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionContinuous infusion of beta-lactam antibiotics .; Therapeutic drug monitoring of beta-lactam antibiotics.
    PhasePhase 4
    Registry statusWithdrawn

  • Pharmacokinetics of Flucloxacillin Given by Continuous or Intermittent Infusion to ICU Patients

    NCT02993575 · start 2017-06-01

    Registered record
    Registry ID
    NCT02993575
    Conditions
    Bacterial Infections
    Interventions
    Flucloxacillin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-06-01
    Completion
    2018-04-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    InterventionFlucloxacillin
    PhaseNot recorded
    Registry statusCompleted

  • Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

    NCT02814916 · start 2017-03-30

    Registered record
    Registry ID
    NCT02814916
    Conditions
    Methicillin-Resistant Staphylococcus Aureus; Bacterial Infections; Staphylococcal Skin Infections
    Interventions
    Dalbavancin; Vancomycin; Oxacillin; Flucloxacillin; Cefadroxil; Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-03-30
    Completion
    2024-01-01
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus; Bacterial Infections; Staphylococcal Skin Infections
    InterventionDalbavancin; Vancomycin; Oxacillin; Flucloxacillin +2 more
    PhasePhase 3
    Registry statusCompleted

  • Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS)

    NCT03120663 · start 2016-11-30

    Registered record
    Registry ID
    NCT03120663
    Conditions
    Surgery
    Interventions
    amoxicillin-clavulanic acid
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-11-30
    Completion
    2018-09-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery
    Interventionamoxicillin-clavulanic acid
    PhaseNot recorded
    Registry statusUnknown

  • Dicloxacillin: Clinical Relevance of Drug-drug Interactions by Induction of Drug Metabolism.

    NCT02983890 · start 2016-10-06

    Registered record
    Registry ID
    NCT02983890
    Conditions
    Healthy
    Interventions
    Dicloxacillin; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-10-06
    Completion
    2017-10-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionDicloxacillin; Placebos
    PhasePhase 1
    Registry statusCompleted

  • Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infection

    NCT02365493 · start 2015-08-26

    Registered record
    Registry ID
    NCT02365493
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Beta-Lactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-08-26
    Completion
    2018-10-24
    Enrolment
    358

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionBeta-Lactam
    PhasePhase 3
    Registry statusTerminated

  • Comparing the Intravenous Treatment of Skin Infections in Children, Home Versus Hospital

    NCT02334124 · start 2015-01

    Registered record
    Registry ID
    NCT02334124
    Conditions
    Cellulitis
    Interventions
    Home; Ward; ceftriaxone; flucloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2022-11
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCellulitis
    InterventionHome; Ward; ceftriaxone; flucloxacillin
    PhaseNot applicable
    Registry statusCompleted

  • A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial

    NCT02208063 · start 2014-12

    Registered record
    Registry ID
    NCT02208063
    Conditions
    Bacteremia
    Interventions
    Telavancin; Vancomycin; Daptomycin; Synthetic penicillin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2014-12
    Completion
    2018-04-12
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionTelavancin; Vancomycin; Daptomycin; Synthetic penicillin +1 more
    PhasePhase 3
    Registry statusTerminated

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

    NCT01792804 · start 2013-12

    Registered record
    Registry ID
    NCT01792804
    Conditions
    Staphylococcus Aureus Infection
    Interventions
    Trimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin; Cloxacillin; Vancomycin; Daptomycin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-12
    Completion
    2020-03-26
    Enrolment
    215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Infection
    InterventionTrimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin +4 more
    PhasePhase 3
    Registry statusCompleted

  • Adjunctive Clindamycin for Cellulitis: C4C Trial.

    NCT01876628 · start 2013-10

    Registered record
    Registry ID
    NCT01876628
    Conditions
    Cellulitis
    Interventions
    Flucloxacillin; Clindamycin; Placebo oral capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-10
    Completion
    2016-03
    Enrolment
    410

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCellulitis
    InterventionFlucloxacillin; Clindamycin; Placebo oral capsule
    PhasePhase 4
    Registry statusCompleted

  • 2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)

    NCT01582360 · start 2013-05

    Registered record
    Registry ID
    NCT01582360
    Conditions
    Critically Ill; Acute Renal Failure; Acute Kidney Injury
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2013-05
    Completion
    2018-01
    Enrolment
    640

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritically Ill; Acute Renal Failure; Acute Kidney Injury
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown