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AMR Drug RepurposingSmart Screeningresearch prototype

Tannic Acid

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Tannic Acid
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Tannic Acid. Its therapeutic class is shown instead.

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

Tannic Acid reaches ≥40% AI-predicted activity against MRSA, but no WHO ATC code or FDA pharmacologic class says whether it is already an antimicrobial. It needs review, so it is not counted among the repurposing candidates.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis34.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tannic Acid in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tannic Acid with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of a Dairy Product for Pregnant and Lactating Women on the Composition of Human Milk

    NCT07173881 · start 2025-08-01

    Registered record
    Registry ID
    NCT07173881
    Conditions
    Pregnancy
    Interventions
    Fortified powder milk
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-08-01
    Completion
    2026-01-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy
    InterventionFortified powder milk
    PhaseNot applicable
    Registry statusRecruiting

  • Metformin Effects on Metabolic, Vitamin B12, Iron, Erythropoietin, and Hematological Parameters in Women With PCOS

    NCT07793838 · start 2025-08-01

    Registered record
    Registry ID
    NCT07793838
    Conditions
    Polycystic Ovary Syndrome (PCOS) Women
    Interventions
    Metformin; Matching Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-08-01
    Completion
    2026-08-01
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Ovary Syndrome (PCOS) Women
    InterventionMetformin; Matching Placebo
    PhasePhase 4
    Registry statusCompleted

  • Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocol

    NCT06990854 · start 2025-07-01

    Registered record
    Registry ID
    NCT06990854
    Conditions
    Postherpetic Neuralgia ( PHN )
    Interventions
    Electroacupuncture (Hans-100A, Nanjing Jisheng Medical Technology, China); Pharmacotherapy：① Pregabalin ( Lyrica™ ，Pfizer Inc. America) ② Methylcobalamin ( Mecobalamin tablets， Weicai (China) Pharmaceutical Co., Ltd， China）; Streitberger Placebo Needle Set ( Asiamed )
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-07-01
    Completion
    2026-12
    Enrolment
    207

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostherpetic Neuralgia ( PHN )
    InterventionElectroacupuncture (Hans-100A, Nanjing Jisheng Medical Technology, China); Pharmacotherapy：① Pregabalin ( Lyrica™ ，Pfizer Inc. America) ② Methylcobalamin ( Mecobalamin tablets， Weicai (China) Pharmaceutical Co., Ltd， China）; Streitberger Placebo Needle Set ( Asiamed )
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain

    NCT06516094 · start 2024-04-11

    Registered record
    Registry ID
    NCT06516094
    Conditions
    Chronic Low-back Pain
    Interventions
    Celecoxib+Pregabalin+Vitamin B fixed dose; Celecoxib + Vitamin B fixed dose; Pregabalin + Vitamin B fixed dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2024-04-11
    Completion
    2025-01-07
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Low-back Pain
    InterventionCelecoxib+Pregabalin+Vitamin B fixed dose; Celecoxib + Vitamin B fixed dose; Pregabalin + Vitamin B fixed dose
    PhasePhase 3
    Registry statusCompleted

  • Effect of Stellate Ganglion Block on Drooling in Parkinson's Syndrome

    NCT06370195 · start 2024-04

    Registered record
    Registry ID
    NCT06370195
    Conditions
    Parkinson's Syndrome
    Interventions
    Comprehensive rehabilitation; Stellate ganglion block; Lidocaine hydrochloride; Placebo injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-04
    Completion
    2024-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson's Syndrome
    InterventionComprehensive rehabilitation; Stellate ganglion block; Lidocaine hydrochloride; Placebo injection
    PhaseNot applicable
    Registry statusUnknown

  • Effectiveness of Stellate Ganglion Block for the Treatment of Obstructive Sleep Apnea

    NCT06319612 · start 2024-03

    Registered record
    Registry ID
    NCT06319612
    Conditions
    Obstructive Sleep Apnea
    Interventions
    routine rehabilitation treatment; Stellate ganglion block; Lidocaine Hydrochloride; Placebo injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-03
    Completion
    2024-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstructive Sleep Apnea
    Interventionroutine rehabilitation treatment; Stellate ganglion block; Lidocaine Hydrochloride; Placebo injection
    PhaseNot applicable
    Registry statusUnknown

  • Efficacy of Stellate Ganglion Block in Children With Cerebral Palsy and Dysphagia

    NCT06211426 · start 2024-01-15

    Registered record
    Registry ID
    NCT06211426
    Conditions
    Cerebral Palsy
    Interventions
    routine rehabilitation treatment; Stellate ganglion block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2024-01-15
    Completion
    2024-04-30
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCerebral Palsy
    Interventionroutine rehabilitation treatment; Stellate ganglion block
    PhaseNot applicable
    Registry statusWithdrawn

  • Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls

    NCT06100146 · start 2023-12-11

    Registered record
    Registry ID
    NCT06100146
    Conditions
    Folate Deficiency; Vitamin B 12 Deficiency; Anemia, Megaloblastic; Cognitive Development; Depressive Symptoms
    Interventions
    Folic acid and vitamin B12 fortified flour; Unfortified cereal flour
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-12-11
    Completion
    2024-08-31
    Enrolment
    472

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFolate Deficiency; Vitamin B 12 Deficiency; Anemia, Megaloblastic; Cognitive Development +1 more
    InterventionFolic acid and vitamin B12 fortified flour; Unfortified cereal flour
    PhaseNot applicable
    Registry statusCompleted

  • SERUM VITAMIN B12 LEVELS IN PATIENTS WITH HEMORRHAGIC VS ISCHEMIC CEREBROVASCULAR EVENT.

    NCT06190314 · start 2023-11-13

    Registered record
    Registry ID
    NCT06190314
    Conditions
    Cerebrovascular Event; Vitamin b12; Hemorrhagic Stroke; Ischemic Stroke
    Interventions
    Measure serum vitamin b12 levels
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-11-13
    Completion
    2024-11-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCerebrovascular Event; Vitamin b12; Hemorrhagic Stroke; Ischemic Stroke
    InterventionMeasure serum vitamin b12 levels
    PhaseNot recorded
    Registry statusUnknown

  • Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels.

    NCT06264570 · start 2023-10-23

    Registered record
    Registry ID
    NCT06264570
    Conditions
    Hyperhomocysteinemia
    Interventions
    B-TMG supplementation; B-SAM supplementation; B-TMG placebo; B-SAM placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2023-10-23
    Completion
    2026-10-30
    Enrolment
    111

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperhomocysteinemia
    InterventionB-TMG supplementation; B-SAM supplementation; B-TMG placebo; B-SAM placebo
    PhaseNot applicable
    Registry statusRecruiting

  • Effects of a Female Hormone Balance Supplement on Symptoms of Polycystic Ovary Syndrome and Severe Premenstrual Syndrome

    NCT06124300 · start 2023-08-30

    Registered record
    Registry ID
    NCT06124300
    Conditions
    Polycystic Ovary Syndrome; Premenstrual Syndrome
    Interventions
    Female Hormone Balance Supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-08-30
    Completion
    2024-01-19
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Ovary Syndrome; Premenstrual Syndrome
    InterventionFemale Hormone Balance Supplement
    PhaseNot applicable
    Registry statusCompleted

  • Pembrolizumab Plus Bevacizumab and Chemotherapy for Non-Squamous NSCLC Patients

    NCT05751187 · start 2023-06-27

    Registered record
    Registry ID
    NCT05751187
    Conditions
    Non-squamous NSCLC
    Interventions
    Pembrolizumab; Bevacizumab; Pemetrexed; Cisplatin; Carboplatin; Folic acid 350-1000 μg; Vitamin B12 1000 μg; Dexamethasone 4 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2023-06-27
    Completion
    2027-12-30
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-squamous NSCLC
    InterventionPembrolizumab; Bevacizumab; Pemetrexed; Cisplatin +4 more
    PhasePhase 2
    Registry statusActive not recruiting

  • Effects of a Combination of Polyphenol-rich Extracts on the Protection of Retinal Cells Against Blue Light in the Prevention of Ocular Diseases

    NCT06004570 · start 2023-06-15

    Registered record
    Registry ID
    NCT06004570
    Conditions
    Eye Abnormalities
    Interventions
    Complex product; Polyphenol-rich extracts; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-15
    Completion
    2023-09-30
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEye Abnormalities
    InterventionComplex product; Polyphenol-rich extracts; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age

    NCT05682261 · start 2023-03-23

    Registered record
    Registry ID
    NCT05682261
    Conditions
    Anemia
    Interventions
    UNIMMAP-MMS; IFA; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-23
    Completion
    2023-10-17
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnemia
    InterventionUNIMMAP-MMS; IFA; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • An Exploratory Investigation of a Supplement to Promote Brain Health

    NCT05520424 · start 2022-06-15

    Registered record
    Registry ID
    NCT05520424
    Conditions
    Memory Deficits; Cognitive Change; Stress
    Interventions
    The Daily Supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-06-15
    Completion
    2022-10-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMemory Deficits; Cognitive Change; Stress
    InterventionThe Daily Supplement
    PhaseNot applicable
    Registry statusCompleted