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AMR Drug RepurposingSmart Screeningresearch prototype

Tannic Acid

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Tannic Acid
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Tannic Acid. Its therapeutic class is shown instead.

Anti-infective classification
Neither a WHO ATC code nor an FDA pharmacologic class was found for it, so whether it is already an antimicrobial is not established. It needs review and is not counted as a repurposing candidate.

Repurposing investigation

Tannic Acid reaches ≥40% AI-predicted activity against MRSA, but no WHO ATC code or FDA pharmacologic class says whether it is already an antimicrobial. It needs review, so it is not counted among the repurposing candidates.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis34.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tannic Acid in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tannic Acid with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Audistim® Day/Night on Hearing Comfort and Patient Quality of Life of Patients With Chronic Tinnitus.

    NCT05300594 · start 2022-03-01

    Registered record
    Registry ID
    NCT05300594
    Conditions
    Tinnitus
    Interventions
    Plant extracts, vitamins and mineral; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-03-01
    Completion
    2023-06-05
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTinnitus
    InterventionPlant extracts, vitamins and mineral; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Examine the Effect of a Thermogenic Energy Drink in Healthy Adults

    NCT05061797 · start 2021-08-23

    Registered record
    Registry ID
    NCT05061797
    Conditions
    Metabolism
    Interventions
    Thermogenic Energy Drink - Active Study Product Formula; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-08-23
    Completion
    2021-11-16
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolism
    InterventionThermogenic Energy Drink - Active Study Product Formula; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Water Soluble Vitamins and Trace Elements Loss in Hemodiafiltration Patients

    NCT05099185 · start 2021-07-19

    Registered record
    Registry ID
    NCT05099185
    Conditions
    Chronic Hemolysis
    Interventions
    Water-soluble vitamins and trace elements measures
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-07-19
    Completion
    2021-12-10
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hemolysis
    InterventionWater-soluble vitamins and trace elements measures
    PhaseNot recorded
    Registry statusCompleted

  • The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient

    NCT04689971 · start 2020-11-03

    Registered record
    Registry ID
    NCT04689971
    Conditions
    Painful Diabetic Neuropathy
    Interventions
    Standard therapy; Vitamin B combination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2020-11-03
    Completion
    2021-11
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPainful Diabetic Neuropathy
    InterventionStandard therapy; Vitamin B combination
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Open Label Study: Treatment of ALS Fatigue With PolyMVA

    NCT04557410 · start 2020-09-23

    Registered record
    Registry ID
    NCT04557410
    Conditions
    Amyotrophic Lateral Sclerosis
    Interventions
    PolyMVA
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-09-23
    Completion
    2021-05-25
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmyotrophic Lateral Sclerosis
    InterventionPolyMVA
    PhasePhase 1
    Registry statusCompleted

  • HGWD Improve the Paclitaxel-related Neurotoxicity in Patients With BC

    NCT05566457 · start 2020-01-01

    Registered record
    Registry ID
    NCT05566457
    Conditions
    Breast Cancer
    Interventions
    Huangqi Guizhi Wuwu decoction (HGWD) infusion packs
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2020-01-01
    Completion
    2023-01-01
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionHuangqi Guizhi Wuwu decoction (HGWD) infusion packs
    PhasePhase 2
    Registry statusUnknown

  • Effect of a Fortified Balanced Energy-Protein Supplement on Birth Outcome and Child Growth in Houndé District, Burkina Faso.

    NCT03533712 · start 2019-10-30

    Registered record
    Registry ID
    NCT03533712
    Conditions
    Small for Gestational Age at Delivery; Low Birth Weight; Prematurity; Infant Malnutrition
    Interventions
    Fortified balanced energy-protein (BEP) supplement; Fe and folic acid supplement
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-10-30
    Completion
    2022-03-15
    Enrolment
    1,788

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSmall for Gestational Age at Delivery; Low Birth Weight; Prematurity; Infant Malnutrition
    InterventionFortified balanced energy-protein (BEP) supplement; Fe and folic acid supplement
    PhasePhase 4
    Registry statusCompleted

  • Quadruple Fortified Salt Clinical Trial

    NCT04404751 · start 2019-08-23

    Registered record
    Registry ID
    NCT04404751
    Conditions
    Anemia
    Interventions
    Iodised salt with Iron, Folic acid and Vitamin B12
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-08-23
    Completion
    2020-12-31
    Enrolment
    174

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnemia
    InterventionIodised salt with Iron, Folic acid and Vitamin B12
    PhaseNot applicable
    Registry statusCompleted

  • Effectiveness of Tricortin 1000 in Patients Affected by Chronic Low Back Pain

    NCT04585334 · start 2019-03-25

    Registered record
    Registry ID
    NCT04585334
    Conditions
    Low Back Pain, Mechanical
    Interventions
    Tricortin 1000; Itami; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-03-25
    Completion
    2025-01
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain, Mechanical
    InterventionTricortin 1000; Itami; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Biomarker Feedback on Health and Wellbeing and Exercise Adherence Following a 6 Month Weight Management Course

    NCT03809871 · start 2019-01-14

    Registered record
    Registry ID
    NCT03809871
    Conditions
    Exercise Training; Biomarkers
    Interventions
    Cardiometabolic biomarkers
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-14
    Completion
    2019-09-24
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExercise Training; Biomarkers
    InterventionCardiometabolic biomarkers
    PhaseNot applicable
    Registry statusCompleted

  • Biological Effects of Treatment With Resveratrol in ART Patients

    NCT04386499 · start 2019-01-10

    Registered record
    Registry ID
    NCT04386499
    Conditions
    Infertility, Female
    Interventions
    Resveratrol; Folic acid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-10
    Completion
    2020-05-05
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    InterventionResveratrol; Folic acid
    PhaseNot applicable
    Registry statusCompleted

  • Evaluate the Neuroprotective Effect of Vitamin B6 and Vitamin B12 Against Vincristine Induced Neurotoxicity in Acute Lymphoblastic Leukaemia Patients

    NCT03593304 · start 2018-03-29

    Registered record
    Registry ID
    NCT03593304
    Conditions
    Vincristine Induced Neurotoxicity; Acute Lymphoblastic Leukaemia
    Interventions
    Injection Mecobalamin; Tablet Pyridoxine hydrochlorid; Normal saline; Oral Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2018-03-29
    Completion
    2019-03-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVincristine Induced Neurotoxicity; Acute Lymphoblastic Leukaemia
    InterventionInjection Mecobalamin; Tablet Pyridoxine hydrochlorid; Normal saline; Oral Placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Effect of Inorganic Nitrate Supplement on Blood Pressure

    NCT03909789 · start 2017-11-17

    Registered record
    Registry ID
    NCT03909789
    Conditions
    Blood Pressure; Endothelial Dysfunction
    Interventions
    Plant based bioequivalent Nitrate supplementation; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-11-17
    Completion
    2018-06-22
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Pressure; Endothelial Dysfunction
    InterventionPlant based bioequivalent Nitrate supplementation; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Red Furu Consumption on Serum Vitamin B12 and Homocysteine Concentration In Healthy Young Volunteers

    NCT03844958 · start 2017-06-15

    Registered record
    Registry ID
    NCT03844958
    Conditions
    Healthy
    Interventions
    Red Furu; Tofu
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-06-15
    Completion
    2017-06-19
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionRed Furu; Tofu
    PhaseNot applicable
    Registry statusCompleted

  • The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota

    NCT03365583 · start 2017-03-03

    Registered record
    Registry ID
    NCT03365583
    Conditions
    Vitamin B 12 Deficiency
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-03-03
    Completion
    2017-11-03
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin B 12 Deficiency
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted