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AMR Drug RepurposingSmart Screeningresearch prototype

Amoxicillin

FDA-approved product (capsule, oral), marketed as Amoxicillin, Amoxicillin Pediatric, Amoxil and 7 more.

Registered studies
50+
Lab records
107
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Amoxicillin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Duodenal ulcer
  • Gonorrhea
  • Infection
  • Infectious otitis media
  • Otitis media
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Tonsillitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA04

Repurposing investigation

Amoxicillin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli30.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae5.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis33.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 20 of 26 lab records
  • E. coli: measured active in 5 of 10 lab records
  • K. pneumoniae: measured active in 3 of 71 lab records
Open Amoxicillin in ChEMBL Registered studies below
Show the 107 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amoxicillin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Enhancing Amoxicillin Pharmacokinetics and Pharmacodynamics Parameters With Probenecid in Bone and Joint Infections

    NCT07764302 · start 2026-12

    Registered record
    Registry ID
    NCT07764302
    Conditions
    Osteoarticular Infections (OAIs)
    Interventions
    Oral probenecid added to oral amoxicillin for osteoarticular infections
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-12
    Completion
    2029-09
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarticular Infections (OAIs)
    InterventionOral probenecid added to oral amoxicillin for osteoarticular infections
    PhasePhase 3
    Registry statusNot yet recruiting

  • Extended Azithromycin Treatment in Prelabor Rupture of Membranes

    NCT07669207 · start 2026-08-19

    Registered record
    Registry ID
    NCT07669207
    Conditions
    Preterm Prelabor Rupture of Membranes; PPROM
    Interventions
    Azithromycin (Azithro); Standard Azithromycin Dosing
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-08-19
    Completion
    2028-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Prelabor Rupture of Membranes; PPROM
    InterventionAzithromycin (Azithro); Standard Azithromycin Dosing
    PhasePhase 4
    Registry statusRecruiting

  • Effect of Bismuth Add-on to Dual Therapy for Helicobacter Pylori Eradication

    NCT07576959 · start 2026-04-08

    Registered record
    Registry ID
    NCT07576959
    Conditions
    HELICOBACTER PYLORI INFECTIONS
    Interventions
    Bismuth Add-on to Vonoprazan Dual Therapy; Vonoprazan dual therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2026-04-08
    Completion
    2032-12-31
    Enrolment
    990

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHELICOBACTER PYLORI INFECTIONS
    InterventionBismuth Add-on to Vonoprazan Dual Therapy; Vonoprazan dual therapy
    PhasePhase 3
    Registry statusRecruiting

  • Traditional vs. Posterior Nasal Radiofrequency Ablation for Chronic Rhinitis

    NCT07323888 · start 2026-03-01

    Registered record
    Registry ID
    NCT07323888
    Conditions
    Nasal Obstruction; Chronic Rhinitis; Nonallergic Rhinitis; Rhinorrhea; Inferior Turbinate Hypertrophy
    Interventions
    Traditional Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Radiofrequency Ablation; Traditional Radiofrequency Ablation of Inferior Turbinates
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2026-03-01
    Completion
    2027-05-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasal Obstruction; Chronic Rhinitis; Nonallergic Rhinitis; Rhinorrhea +1 more
    InterventionTraditional Radiofrequency Ablation of Inferior Turbinates With Posterior Nasal Radiofrequency Ablation; Traditional Radiofrequency Ablation of Inferior Turbinates
    PhaseNot applicable
    Registry statusActive not recruiting

  • The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health

    NCT06378502 · start 2024-05-03

    Registered record
    Registry ID
    NCT06378502
    Conditions
    Antibiotic
    Interventions
    Amoxicillin Short; Amoxicillin Long
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-05-03
    Completion
    2026-06-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic
    InterventionAmoxicillin Short; Amoxicillin Long
    PhasePhase 4
    Registry statusUnknown

  • Comparison of Two Dual Therapies in the First-line Treatment of Helicobacter Pylori Infection （SHARE2301）

    NCT05870683 · start 2023-05-24

    Registered record
    Registry ID
    NCT05870683
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Tegoprazan; Amoxicillin; Esomeprazole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-05-24
    Completion
    2023-12-30
    Enrolment
    368

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionTegoprazan; Amoxicillin; Esomeprazole
    PhaseNot applicable
    Registry statusUnknown

  • Helicobacter Pylori and Vonoprazan Dual Therapy

    NCT05649709 · start 2023-02-13

    Registered record
    Registry ID
    NCT05649709
    Conditions
    Helicobacter Pylori
    Interventions
    L-VA dual therapy; H-VA dual therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-02-13
    Completion
    2024-01-25
    Enrolment
    504

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori
    InterventionL-VA dual therapy; H-VA dual therapy
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation

    NCT04552080 · start 2022-12-29

    Registered record
    Registry ID
    NCT04552080
    Conditions
    Patients Undergoing Oral Implant Therapy
    Interventions
    Amoxicillin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-12-29
    Completion
    2026-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Undergoing Oral Implant Therapy
    InterventionAmoxicillin; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome

    NCT05302531 · start 2022-12-09

    Registered record
    Registry ID
    NCT05302531
    Conditions
    Short Bowel Syndrome; Infection, Bacterial
    Interventions
    Amoxicillin; Levofloxacin; Ofloxacin; Sulfamethoxazole trimethoprim
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-12-09
    Completion
    2025-02
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShort Bowel Syndrome; Infection, Bacterial
    InterventionAmoxicillin; Levofloxacin; Ofloxacin; Sulfamethoxazole trimethoprim
    PhasePhase 1
    Registry statusUnknown

  • One vs Two Weeks Treatment for H.Pylori Eradication A RANDOMIZED NON-INFERIORITY PLACEBO CONTROLLED TRIAL

    NCT05728424 · start 2022-09-20

    Registered record
    Registry ID
    NCT05728424
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Vonoprazan, Amoxicillin, Levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-09-20
    Completion
    2023-05-01
    Enrolment
    246

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionVonoprazan, Amoxicillin, Levofloxacin
    PhasePhase 3
    Registry statusUnknown

  • Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication

    NCT05469685 · start 2022-08-01

    Registered record
    Registry ID
    NCT05469685
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Vonoprazan; Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-08-01
    Completion
    2023-09-30
    Enrolment
    914

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionVonoprazan; Amoxicillin
    PhasePhase 4
    Registry statusCompleted

  • Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.

    NCT05432115 · start 2022-06-25

    Registered record
    Registry ID
    NCT05432115
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Tetracyclin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-06-25
    Completion
    2023-10
    Enrolment
    407

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionTetracyclin
    PhasePhase 4
    Registry statusUnknown

  • Collaborative Urological Prosthetics Investigation Directive Research Group

    NCT05100654 · start 2022-04-22

    Registered record
    Registry ID
    NCT05100654
    Conditions
    Erectile Dysfunction; Penile Prosthesis Infection
    Interventions
    Doxycycline; Ciprofloxacin; Augmentin; Bactrim
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Active not recruiting
    Start
    2022-04-22
    Completion
    2028-01-01
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction; Penile Prosthesis Infection
    InterventionDoxycycline; Ciprofloxacin; Augmentin; Bactrim
    PhaseEarly phase 1
    Registry statusActive not recruiting

  • Bismuth-containing Quadruple Therapy for Helicobacter Pylori Eradication: A Randomized Clinical Trial of 10 and 14 Days

    NCT04901117 · start 2021-06

    Registered record
    Registry ID
    NCT04901117
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Amoxicillin; Clarithromycin; Tetracycline; Metronidazole; Bismuth Potassium Citrate; Colloidal Bismuth Pectin; Vonoprazan fumarate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-06
    Completion
    2023-08
    Enrolment
    1,300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionAmoxicillin; Clarithromycin; Tetracycline; Metronidazole +3 more
    PhasePhase 4
    Registry statusUnknown

  • Effects of Nasal-spraying LiveSpo Navax in Treatment of Influenza Virus in Children

    NCT05378022 · start 2020-12-21

    Registered record
    Registry ID
    NCT05378022
    Conditions
    Acute Respiratory Tract Infections
    Interventions
    LiveSpo Navax; 0.9% NaCl physiological saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-12-21
    Completion
    2022-04-22
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Tract Infections
    InterventionLiveSpo Navax; 0.9% NaCl physiological saline
    PhaseNot applicable
    Registry statusCompleted