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AMR Drug RepurposingSmart Screeningresearch prototype

Amoxicillin

FDA-approved product (capsule, oral), marketed as Amoxicillin, Amoxicillin Pediatric, Amoxil and 7 more.

Registered studies
50+
Lab records
107
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Amoxicillin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Duodenal ulcer
  • Gonorrhea
  • Infection
  • Infectious otitis media
  • Otitis media
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Tonsillitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA04

Repurposing investigation

Amoxicillin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli30.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae5.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis33.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 20 of 26 lab records
  • E. coli: measured active in 5 of 10 lab records
  • K. pneumoniae: measured active in 3 of 71 lab records
Open Amoxicillin in ChEMBL Registered studies below
Show the 107 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amoxicillin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

    NCT02281929 · start 2015-06-13

    Registered record
    Registry ID
    NCT02281929
    Conditions
    Alcoholic Hepatitis; Alcoholic Liver Disease
    Interventions
    Amoxicillin; Placebo; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-06-13
    Completion
    2019-11-19
    Enrolment
    297

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholic Hepatitis; Alcoholic Liver Disease
    InterventionAmoxicillin; Placebo; Prednisolone
    PhasePhase 3
    Registry statusCompleted

  • Preschool Wheeze: Inflammation/Infection Guided Management

    NCT02517099 · start 2015-06-05

    Registered record
    Registry ID
    NCT02517099
    Conditions
    Asthma
    Interventions
    Beclometasone; Co-amoxiclav; Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06-05
    Completion
    2018-08-17
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionBeclometasone; Co-amoxiclav; Azithromycin
    PhasePhase 2
    Registry statusCompleted

  • Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis

    NCT03615781 · start 2015-06-01

    Registered record
    Registry ID
    NCT03615781
    Conditions
    Arthritis, Septic
    Interventions
    Two week's arm - surgery; Four week's arm - surgery; Two week's arm - drugs; Four week's arm - drugs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2018-05-18
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Septic
    InterventionTwo week's arm - surgery; Four week's arm - surgery; Two week's arm - drugs; Four week's arm - drugs
    PhaseNot applicable
    Registry statusCompleted

  • Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health

    NCT05553743 · start 2014-03-27

    Registered record
    Registry ID
    NCT05553743
    Conditions
    Breastfeeding; COVID-19 Infection; COVID-19 Vaccine; Remdesivir; Antibiotics
    Interventions
    COVID-19 Exposure; Antibiotic
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2014-03-27
    Completion
    2040-03
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreastfeeding; COVID-19 Infection; COVID-19 Vaccine; Remdesivir +1 more
    InterventionCOVID-19 Exposure; Antibiotic
    PhaseNot recorded
    Registry statusRecruiting

  • A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide

    NCT02090738 · start 2014-03

    Registered record
    Registry ID
    NCT02090738
    Conditions
    H. Pylori Infection
    Interventions
    Acetazolamide group; Standard regimen group
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2014-03
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionH. Pylori Infection
    InterventionAcetazolamide group; Standard regimen group
    PhasePhase 2
    Registry statusWithdrawn

  • Phase I Study of Safety and Immunogenicity of ADU-623

    NCT01967758 · start 2014-01-08

    Registered record
    Registry ID
    NCT01967758
    Conditions
    Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    Interventions
    Cohort 1; Cohort 2; Cohort 3; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01-08
    Completion
    2018-08-15
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAstrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    InterventionCohort 1; Cohort 2; Cohort 3; Antibiotics
    PhasePhase 1
    Registry statusCompleted

  • A Study to Evaluate the Effect and Safety of Idoform Plus on Bowel Side Effects in Healthy Subjects Treated With Amoxicillin/ Clavulanate

    NCT01491659 · start 2013-01

    Registered record
    Registry ID
    NCT01491659
    Conditions
    Diarrhoea
    Interventions
    Idoform Plus; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2013-01
    Completion
    2013-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiarrhoea
    InterventionIdoform Plus; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis

    NCT00716183 · start 2008-07

    Registered record
    Registry ID
    NCT00716183
    Conditions
    Mastitis
    Interventions
    Lactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-05
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMastitis
    InterventionLactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures

    NCT01524081 · start 2008-07

    Registered record
    Registry ID
    NCT01524081
    Conditions
    Acute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    Interventions
    Metronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2011-11
    Enrolment
    187

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    InterventionMetronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)

    NCT01406275 · start 2008-01

    Registered record
    Registry ID
    NCT01406275
    Conditions
    Otitis Maedia
    Interventions
    Amoxicillin and clavulanate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-12
    Enrolment
    363

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Maedia
    InterventionAmoxicillin and clavulanate
    PhaseNot recorded
    Registry statusCompleted

  • Middle Meatal Bacteriology During Acute Respiratory Infection in Children

    NCT00545961 · start 2007-11

    Registered record
    Registry ID
    NCT00545961
    Conditions
    Acute Respiratory Infection; Sinusitis
    Interventions
    placebo; amoxicillin clavulanate acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-11
    Completion
    2009-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Infection; Sinusitis
    Interventionplacebo; amoxicillin clavulanate acid
    PhasePhase 4
    Registry statusUnknown

  • Zmax Compared to Augmentin in Sinusitis

    NCT00367120 · start 2006-06

    Registered record
    Registry ID
    NCT00367120
    Conditions
    Sinusitis
    Interventions
    Azithromycin Extended Release; Amoxicillin/Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-02
    Enrolment
    762

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAzithromycin Extended Release; Amoxicillin/Clavulanate
    PhasePhase 4
    Registry statusCompleted

  • Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment

    NCT03933501 · start 2006-01-01

    Registered record
    Registry ID
    NCT03933501
    Conditions
    Generalized Aggressive Periodontitis
    Interventions
    amoxicillin and metronidazole; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01-01
    Completion
    2018-12-01
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Aggressive Periodontitis
    Interventionamoxicillin and metronidazole; Placebos
    PhasePhase 4
    Registry statusCompleted

  • Guidelines for Acute Sinusitis

    NCT00132275 · start 2003-11

    Registered record
    Registry ID
    NCT00132275
    Conditions
    Sinusitis
    Interventions
    Amoxicillin potassium clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-11
    Completion
    2006-08
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAmoxicillin potassium clavulanate
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

    NCT00066066 · start 2003-07

    Registered record
    Registry ID
    NCT00066066
    Conditions
    Periodontitis; Periodontal Diseases
    Interventions
    Scaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-07
    Completion
    2009-07
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis; Periodontal Diseases
    InterventionScaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    PhasePhase 2
    Registry statusCompleted