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AMR Drug RepurposingSmart Screeningresearch prototype

Amoxicillin

FDA-approved product (capsule, oral), marketed as Amoxicillin, Amoxicillin Pediatric, Amoxil and 7 more.

Registered studies
50+
Lab records
107
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Amoxicillin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Duodenal ulcer
  • Gonorrhea
  • Infection
  • Infectious otitis media
  • Otitis media
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Tonsillitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA04

Repurposing investigation

Amoxicillin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli30.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae5.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis33.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 20 of 26 lab records
  • E. coli: measured active in 5 of 10 lab records
  • K. pneumoniae: measured active in 3 of 71 lab records
Open Amoxicillin in ChEMBL Registered studies below
Show the 107 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amoxicillin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal

    NCT03702270 · start 2020-11-11

    Registered record
    Registry ID
    NCT03702270
    Conditions
    Penicillin Allergy
    Interventions
    Penicillin Allergic Risk Stratification Best Practice Alert
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-11-11
    Completion
    2023-05-11
    Enrolment
    2,052

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPenicillin Allergy
    InterventionPenicillin Allergic Risk Stratification Best Practice Alert
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

    NCT04041791 · start 2019-08-19

    Registered record
    Registry ID
    NCT04041791
    Conditions
    Pneumonia
    Interventions
    Benzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate; Intravenous fluid; Nasogastric feeds; Ampicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-08-19
    Completion
    2024-04-05
    Enrolment
    4,392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionBenzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate +3 more
    PhasePhase 3
    Registry statusCompleted

  • Intraluminal Mono-antibiotic Therapy for Helicobacter Pylori Infection - A Comparison of Levofloxacin Powder and Levofloxacin Solution

    NCT03832465 · start 2019-06-14

    Registered record
    Registry ID
    NCT03832465
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Levofloxacin film-coated tablet; Levofloxacin intravenous solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-06-14
    Completion
    2020-12-27
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionLevofloxacin film-coated tablet; Levofloxacin intravenous solution
    PhasePhase 4
    Registry statusCompleted

  • Empirical vs Tailored Therapy for H. Pylori Infection

    NCT04006340 · start 2019-01-04

    Registered record
    Registry ID
    NCT04006340
    Conditions
    Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation; Helicobacter Pylori Infection
    Interventions
    triple therapy; quadruple therapy; dual-priming oligonucleotide-based multiplex (DPO)-PCR test
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-01-04
    Completion
    2019-08-31
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation; Helicobacter Pylori Infection
    Interventiontriple therapy; quadruple therapy; dual-priming oligonucleotide-based multiplex (DPO)-PCR test
    PhaseNot applicable
    Registry statusUnknown

  • Tailored Therapy for Clarithromycin-Resistant H. Pylori

    NCT03431688 · start 2018-10-01

    Registered record
    Registry ID
    NCT03431688
    Conditions
    Helicobacter Pylori Infection
    Interventions
    PAM; PBMT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-10-01
    Completion
    2020-12-30
    Enrolment
    782

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionPAM; PBMT
    PhaseNot applicable
    Registry statusCompleted

  • RCT of Efficacy of Amoxicillin Over Ampicillin on Severe Pneumonia

    NCT03369093 · start 2018-01-01

    Registered record
    Registry ID
    NCT03369093
    Conditions
    Treatment Failure; Lethargy; Altered Mental Status; Convulsion, Non-Epileptic; Hypoxia; Feeding; Difficult, Newborn
    Interventions
    Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-01
    Completion
    2019-12-31
    Enrolment
    308

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTreatment Failure; Lethargy; Altered Mental Status; Convulsion, Non-Epileptic +3 more
    InterventionAmoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Helicobacter Pylori Eradication in Functional Dyspepsia

    NCT04697641 · start 2017-09-01

    Registered record
    Registry ID
    NCT04697641
    Conditions
    Dyspepsia; Helicobacter Pylori Infection
    Interventions
    Clarithromycin 500mg; Amoxicillin 1000 MG; Pantoprazole 40mg; Levosulpiride; Acotiamide; Itopride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-09-01
    Completion
    2019-05-31
    Enrolment
    202

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyspepsia; Helicobacter Pylori Infection
    InterventionClarithromycin 500mg; Amoxicillin 1000 MG; Pantoprazole 40mg; Levosulpiride +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES)

    NCT03607734 · start 2017-04-24

    Registered record
    Registry ID
    NCT03607734
    Conditions
    Allergy
    Interventions
    Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-04-24
    Completion
    2017-10-02
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    InterventionAmoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • A Study on Eradication Rate of Triple Therapy According to Treatment Period and CYP2C19 Polymorphisms in H.Pylori Patients

    NCT03099876 · start 2017-03-01

    Registered record
    Registry ID
    NCT03099876
    Conditions
    Helicobacter Pylori Infection
    Interventions
    treatment period
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-03-01
    Completion
    2018-12-01
    Enrolment
    320

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    Interventiontreatment period
    PhaseNot recorded
    Registry statusUnknown

  • Tailored H. Pylori Eradication Based on Clarithromycin Resistance

    NCT03884348 · start 2017-01-01

    Registered record
    Registry ID
    NCT03884348
    Conditions
    Helicobacter Pylori Infection; Antibiotic Resistant Strain
    Interventions
    proton pump inhibitor, amoxicillin, clarithromycin; proton pump inhibitor, amoxicillin, metronidazole
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-01-01
    Completion
    2018-12-31
    Enrolment
    431

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection; Antibiotic Resistant Strain
    Interventionproton pump inhibitor, amoxicillin, clarithromycin; proton pump inhibitor, amoxicillin, metronidazole
    PhaseNot recorded
    Registry statusCompleted

  • Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study

    NCT03003273 · start 2017-01

    Registered record
    Registry ID
    NCT03003273
    Conditions
    Neutropenia, Febrile; Pediatric Cancer
    Interventions
    stoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2017-01
    Completion
    2018-12
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia, Febrile; Pediatric Cancer
    Interventionstoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    PhasePhase 3
    Registry statusTerminated

  • Helicobacter Pylori Eradication Study

    NCT03130452 · start 2016-12-17

    Registered record
    Registry ID
    NCT03130452
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Lansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-12-17
    Completion
    2019-05-31
    Enrolment
    423

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionLansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    PhasePhase 4
    Registry statusCompleted

  • Platform Switched Implant and Bone Level Alteration

    NCT02867982 · start 2016-07

    Registered record
    Registry ID
    NCT02867982
    Conditions
    Edentulous; Bone Resorption
    Interventions
    Subcrestal implant placement; Paracrestal implant placement; prophylactic antibiotics; dental implant; x-ray examination
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-07
    Completion
    2020-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEdentulous; Bone Resorption
    InterventionSubcrestal implant placement; Paracrestal implant placement; prophylactic antibiotics; dental implant +1 more
    PhaseNot applicable
    Registry statusUnknown

  • The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients

    NCT02648659 · start 2016-03-02

    Registered record
    Registry ID
    NCT02648659
    Conditions
    Peptic Ulcer
    Interventions
    Ilaprazole; Amoxicillin; Clarithromycin; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03-02
    Completion
    2017-02-14
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeptic Ulcer
    InterventionIlaprazole; Amoxicillin; Clarithromycin; Metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Integrated Community Case Management Study in Eastern Province, Zambia

    NCT02866097 · start 2016-03

    Registered record
    Registry ID
    NCT02866097
    Conditions
    Malaria; Diarrhea; Pneumonia
    Interventions
    mHealth inventory management; Supportive supervision; ICCM current standard of care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-03
    Completion
    2016-09
    Enrolment
    3,840

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Diarrhea; Pneumonia
    InterventionmHealth inventory management; Supportive supervision; ICCM current standard of care
    PhaseNot applicable
    Registry statusUnknown