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AMR Drug RepurposingSmart Screeningresearch prototype

Ciclesonide

FDA-approved product (aerosol, metered, inhalation), marketed as Alvesco, Omnaris, Zetonna.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Ciclesonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Nasal congestion
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ciclesonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ciclesonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Responsiveness of Lower Airways in Adult Patients (18-60 Years) With Stable Asthma After Treatment With Ciclesonide and Fluticasone Propionate (BY9010/NL-101)

    NCT00306163 · start 2006-05

    Registered record
    Registry ID
    NCT00306163
    Conditions
    Asthma
    Interventions
    Ciclesonide; Fluticasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-05
    Completion
    2008-09
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Fluticasone
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Ciclesonide in Preschool Children With Asthma (2 to 6 Years) (BY9010/M1-207)

    NCT00163449 · start 2005-11

    Registered record
    Registry ID
    NCT00163449
    Conditions
    Asthma
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-11
    Completion
    2007-05
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effects of Inhaled Ciclesonide Versus Fluticasone Propionate Versus Placebo on Lower Leg Growth in Prepubertal Children With Mild Persistent Asthma (6 to 12 y) (BY9010/M1-208)

    NCT00163371 · start 2005-09

    Registered record
    Registry ID
    NCT00163371
    Conditions
    Asthma
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-09
    Completion
    2005-12
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide vs Placebo Administered as Once Daily or Twice Daily in Patients Not Treated With Inhaled Corticosteroid.

    NCT00174720 · start 2005-09

    Registered record
    Registry ID
    NCT00174720
    Conditions
    Asthma
    Interventions
    Ciclesonide (XRP1526)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-09
    Completion
    2007-02
    Enrolment
    708

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide (XRP1526)
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide Versus Placebo Administered Either as Once Daily or Twice Daily in Patients Treated Previously With an Inhaled Corticosteroid

    NCT00174733 · start 2005-07

    Registered record
    Registry ID
    NCT00174733
    Conditions
    Asthma
    Interventions
    Ciclesonide (XRP1526)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-07
    Completion
    2006-02
    Enrolment
    456

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide (XRP1526)
    PhasePhase 3
    Registry statusCompleted

  • Dose Response Study of Inhaled Ciclesonide (Glucocorticosteroid) to Patients With Persistent Asthma

    NCT00174746 · start 2005-03

    Registered record
    Registry ID
    NCT00174746
    Conditions
    Asthma
    Interventions
    AVE2635A
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-03
    Completion
    2005-11
    Enrolment
    1,145

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionAVE2635A
    PhasePhase 2
    Registry statusCompleted

  • Study Using the Environmental Exposure Unit (EEU) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-407)

    NCT00659503 · start 2005-02

    Registered record
    Registry ID
    NCT00659503
    Conditions
    Rhinitis, Allergic, Seasonal; Hay Fever
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-02
    Completion
    2005-11
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal; Hay Fever
    InterventionCiclesonide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101)

    NCT00163293 · start 2005-01-01

    Registered record
    Registry ID
    NCT00163293
    Conditions
    Asthma
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-01-01
    Completion
    2010-04-01
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Safety of Ciclesonide Nasal Spray Administered With Inhaled Fluticasone Dipropionate/Salmeterol in Adults With Perennial Allergic Rhinitis (BY9010/M1-409)

    NCT00163488 · start 2005-01

    Registered record
    Registry ID
    NCT00163488
    Conditions
    Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-08
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide and Fluticasone Propionate in Adult Patients With Moderate and Severe Persistent Asthma (18 to 75 y) (BY9010/IT-101)

    NCT00163319 · start 2004-11

    Registered record
    Registry ID
    NCT00163319
    Conditions
    Asthma
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-11
    Completion
    2005-11
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide Versus Fluticasone Propionate in Patients With Mild to Moderate Asthma (12 to 75 y) (BY9010/M1-142)

    NCT00163423 · start 2004-11

    Registered record
    Registry ID
    NCT00163423
    Conditions
    Asthma
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-11
    Completion
    2006-01
    Enrolment
    480

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Ciclesonide Inhaled Once Daily Versus Fluticasone Propionate Inhaled Twice Daily in Children With Asthma (6 to 11 y) (BY9010/M1-206)

    NCT00163462 · start 2004-10

    Registered record
    Registry ID
    NCT00163462
    Conditions
    Asthma
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2005-11
    Enrolment
    750

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Safety and Effectiveness of Ciclesonide Nasal Spray in Children (6 to 11 Years) With Perennial Allergic Rhinitis (BY9010/M1-403)

    NCT00163514 · start 2004-05

    Registered record
    Registry ID
    NCT00163514
    Conditions
    Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-05
    Completion
    2005-07
    Enrolment
    636

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • Safety and Effectiveness of Ciclesonide Nasal Spray in Patients With Perennial Allergic Rhinitis During One Year Treatment (BY9010/M1-404)

    NCT00163501 · start 2003-12

    Registered record
    Registry ID
    NCT00163501
    Conditions
    Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    Interventions
    Ciclesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-12
    Completion
    2005-04
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
    InterventionCiclesonide
    PhasePhase 3
    Registry statusCompleted

  • To Assess the Safety and Efficacy of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-401)

    NCT00659841 · start 2003-12

    Registered record
    Registry ID
    NCT00659841
    Conditions
    Rhinitis, Allergic, Seasonal; Hay Fever
    Interventions
    Ciclesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-12
    Completion
    2005-02
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal; Hay Fever
    InterventionCiclesonide; Placebo
    PhasePhase 3
    Registry statusCompleted