Ciclesonide
FDA-approved product (aerosol, metered, inhalation), marketed as Alvesco, Omnaris, Zetonna.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Airway obstruction
- Allergic rhinitis
- Asthma
- Nasal congestion
- Rhinitis, Allergic, Perennial
- Seasonal allergic rhinitis
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Corticosteroids; Glucocorticoids
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA60.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae29.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis36.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Ciclesonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Cetrorelix AcetateExisting use: Ovulation Inhibition, Positive regulation of ovulation63.2% AI-predicted activityagainst MRSA50+ registered studies
- HexachloropheneExisting use: Phenol and derivatives63.2% AI-predicted activityagainst MRSALab records exist3 registered studies
- LorlatinibExisting use: Cancer, Lymphoma, Neoplasm and 1 more63.1% AI-predicted activityagainst MRSA50+ registered studies
- Alectinib HydrochlorideExisting use: Cancer, Neoplasm, Non-small cell lung carcinoma63.0% AI-predicted activityagainst MRSA13 registered studies
- AlpelisibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 2 more63.0% AI-predicted activityagainst MRSA50+ registered studies
- Histrelin AcetateExisting use: Neoplasm, Prostate adenocarcinoma, Prostate cancer62.9% AI-predicted activityagainst MRSA13 registered studies
- Degarelix AcetateExisting use: Prostate adenocarcinoma, Prostate cancer, Prostate carcinoma62.9% AI-predicted activityagainst MRSA50+ registered studies
- Lasmiditan SuccinateExisting use: Migraine disorder62.8% AI-predicted activityagainst MRSANo documented evidence found
- TacrolimusExisting use: Atopic eczema, Delayed Graft Function, Eczematoid dermatitis and 3 more62.5% AI-predicted activityagainst MRSA50+ registered studies
- Rezafungin AcetateExisting use: Candidemia, Candidiasis, Candidiasis, Invasive62.4% AI-predicted activityagainst MRSA5 registered studies
- AvapritinibExisting use: Cancer, Gastrointestinal stromal tumor, Neoplasm62.2% AI-predicted activityagainst MRSA30 registered studies
- Ceruletide DiethylamineExisting use: Tests for bile duct patency62.2% AI-predicted activityagainst MRSANo documented evidence found
Registered studies
A registration describes a study; it does not establish a positive result.
Responsiveness of Lower Airways in Adult Patients (18-60 Years) With Stable Asthma After Treatment With Ciclesonide and Fluticasone Propionate (BY9010/NL-101)
NCT00306163 · start 2006-05
Registered record
- Registry ID
- NCT00306163
- Conditions
- Asthma
- Interventions
- Ciclesonide; Fluticasone
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2006-05
- Completion
- 2008-09
- Enrolment
- 37
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonide; FluticasonePhasePhase 3Registry statusCompletedEfficacy and Safety of Ciclesonide in Preschool Children With Asthma (2 to 6 Years) (BY9010/M1-207)
NCT00163449 · start 2005-11
Registered record
- Registry ID
- NCT00163449
- Conditions
- Asthma
- Interventions
- Ciclesonide; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-11
- Completion
- 2007-05
- Enrolment
- 1,000
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonide; PlaceboPhasePhase 3Registry statusCompletedEffects of Inhaled Ciclesonide Versus Fluticasone Propionate Versus Placebo on Lower Leg Growth in Prepubertal Children With Mild Persistent Asthma (6 to 12 y) (BY9010/M1-208)
NCT00163371 · start 2005-09
Registered record
- Registry ID
- NCT00163371
- Conditions
- Asthma
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-09
- Completion
- 2005-12
- Enrolment
- 28
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonidePhasePhase 3Registry statusCompletedEfficacy of Ciclesonide vs Placebo Administered as Once Daily or Twice Daily in Patients Not Treated With Inhaled Corticosteroid.
NCT00174720 · start 2005-09
Registered record
- Registry ID
- NCT00174720
- Conditions
- Asthma
- Interventions
- Ciclesonide (XRP1526)
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-09
- Completion
- 2007-02
- Enrolment
- 708
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonide (XRP1526)PhasePhase 3Registry statusCompletedEfficacy of Ciclesonide Versus Placebo Administered Either as Once Daily or Twice Daily in Patients Treated Previously With an Inhaled Corticosteroid
NCT00174733 · start 2005-07
Registered record
- Registry ID
- NCT00174733
- Conditions
- Asthma
- Interventions
- Ciclesonide (XRP1526)
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-07
- Completion
- 2006-02
- Enrolment
- 456
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonide (XRP1526)PhasePhase 3Registry statusCompletedDose Response Study of Inhaled Ciclesonide (Glucocorticosteroid) to Patients With Persistent Asthma
NCT00174746 · start 2005-03
Registered record
- Registry ID
- NCT00174746
- Conditions
- Asthma
- Interventions
- AVE2635A
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-03
- Completion
- 2005-11
- Enrolment
- 1,145
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionAVE2635APhasePhase 2Registry statusCompletedStudy Using the Environmental Exposure Unit (EEU) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-407)
NCT00659503 · start 2005-02
Registered record
- Registry ID
- NCT00659503
- Conditions
- Rhinitis, Allergic, Seasonal; Hay Fever
- Interventions
- Ciclesonide; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-02
- Completion
- 2005-11
- Enrolment
- 420
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRhinitis, Allergic, Seasonal; Hay FeverInterventionCiclesonide; PlaceboPhasePhase 3Registry statusCompletedEfficacy of Ciclesonide Inhaled Once Daily Versus Other Corticosteroids Used for Treatment of Mild Asthma in Children (4 to 11 Years) (BY9010/CA-101)
NCT00163293 · start 2005-01-01
Registered record
- Registry ID
- NCT00163293
- Conditions
- Asthma
- Interventions
- Ciclesonide; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-01-01
- Completion
- 2010-04-01
- Enrolment
- 240
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonide; PlaceboPhasePhase 3Registry statusCompletedSafety of Ciclesonide Nasal Spray Administered With Inhaled Fluticasone Dipropionate/Salmeterol in Adults With Perennial Allergic Rhinitis (BY9010/M1-409)
NCT00163488 · start 2005-01
Registered record
- Registry ID
- NCT00163488
- Conditions
- Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2005-01
- Completion
- 2005-08
- Enrolment
- 106
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay FeverInterventionCiclesonidePhasePhase 3Registry statusCompletedEfficacy of Ciclesonide and Fluticasone Propionate in Adult Patients With Moderate and Severe Persistent Asthma (18 to 75 y) (BY9010/IT-101)
NCT00163319 · start 2004-11
Registered record
- Registry ID
- NCT00163319
- Conditions
- Asthma
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-11
- Completion
- 2005-11
- Enrolment
- 500
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonidePhasePhase 3Registry statusCompletedEfficacy of Ciclesonide Versus Fluticasone Propionate in Patients With Mild to Moderate Asthma (12 to 75 y) (BY9010/M1-142)
NCT00163423 · start 2004-11
Registered record
- Registry ID
- NCT00163423
- Conditions
- Asthma
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-11
- Completion
- 2006-01
- Enrolment
- 480
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonidePhasePhase 3Registry statusCompletedEfficacy of Ciclesonide Inhaled Once Daily Versus Fluticasone Propionate Inhaled Twice Daily in Children With Asthma (6 to 11 y) (BY9010/M1-206)
NCT00163462 · start 2004-10
Registered record
- Registry ID
- NCT00163462
- Conditions
- Asthma
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-10
- Completion
- 2005-11
- Enrolment
- 750
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAsthmaInterventionCiclesonidePhasePhase 3Registry statusCompletedSafety and Effectiveness of Ciclesonide Nasal Spray in Children (6 to 11 Years) With Perennial Allergic Rhinitis (BY9010/M1-403)
NCT00163514 · start 2004-05
Registered record
- Registry ID
- NCT00163514
- Conditions
- Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-05
- Completion
- 2005-07
- Enrolment
- 636
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay FeverInterventionCiclesonidePhasePhase 3Registry statusCompletedSafety and Effectiveness of Ciclesonide Nasal Spray in Patients With Perennial Allergic Rhinitis During One Year Treatment (BY9010/M1-404)
NCT00163501 · start 2003-12
Registered record
- Registry ID
- NCT00163501
- Conditions
- Perennial Allergic Rhinitis; Allergic Rhinitis; Hay Fever
- Interventions
- Ciclesonide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2003-12
- Completion
- 2005-04
- Enrolment
- 600
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPerennial Allergic Rhinitis; Allergic Rhinitis; Hay FeverInterventionCiclesonidePhasePhase 3Registry statusCompletedTo Assess the Safety and Efficacy of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-401)
NCT00659841 · start 2003-12
Registered record
- Registry ID
- NCT00659841
- Conditions
- Rhinitis, Allergic, Seasonal; Hay Fever
- Interventions
- Ciclesonide; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2003-12
- Completion
- 2005-02
- Enrolment
- 302
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRhinitis, Allergic, Seasonal; Hay FeverInterventionCiclesonide; PlaceboPhasePhase 3Registry statusCompleted