Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Pyridoxine Hydrochloride

FDA-approved product (injectable, injection), marketed as Hexa-Betalin, Pyridoxine Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Pyridoxine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia
  • Anemia (phenotype)
  • Chronic kidney disease
  • Folate deficiency
  • Iron deficiency anemia
  • Nausea and vomiting
  • Osteoporosis
  • Type 2 diabetes mellitus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other plain vitamin preparations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Pyridoxine Hydrochloride, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA27.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli23.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae12.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis14.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Pyridoxine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pyridoxine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Date Fruit Benefits to Treat Morning Sickness in First Trimester of Pregnancy

    NCT07354529 · start 2025-06-15

    Registered record
    Registry ID
    NCT07354529
    Conditions
    Pregnancy
    Interventions
    Date fruit; Doxylamine succinate 10 mg + Pyridoxine HCl 10 mg; Diet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2025-06-15
    Completion
    2026-02-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy
    InterventionDate fruit; Doxylamine succinate 10 mg + Pyridoxine HCl 10 mg; Diet
    PhaseNot applicable
    Registry statusActive not recruiting

  • Clinical Trial Assessing Godex Carnitine Orotate Complex in Nonalcoholic Fatty Liver Disease Patients for Efficacy

    NCT06152991 · start 2023-09-25

    Registered record
    Registry ID
    NCT06152991
    Conditions
    Non-Alcoholic Fatty Liver Disease
    Interventions
    GODEX; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Enrolling by invitation
    Start
    2023-09-25
    Completion
    2027-02-26
    Enrolment
    196

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-Alcoholic Fatty Liver Disease
    InterventionGODEX; Placebo
    PhasePhase 3
    Registry statusEnrolling by invitation

  • Isoniazid Prophylaxis Based on Risk Factors of Tuberculosis in Living Kidney Transplantation Recipients

    NCT06512831 · start 2023-06-01

    Registered record
    Registry ID
    NCT06512831
    Conditions
    Kidney Transplantation; Tuberculosis; Isoniazid Toxicity
    Interventions
    Isoniazid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-01
    Completion
    2024-03-01
    Enrolment
    1,348

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation; Tuberculosis; Isoniazid Toxicity
    InterventionIsoniazid
    PhaseNot applicable
    Registry statusCompleted

  • Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis

    NCT05473520 · start 2023-05-24

    Registered record
    Registry ID
    NCT05473520
    Conditions
    Tuberculosis; Acute Coronary Syndrome; Pulmonary Hypertension (Diagnosis)
    Interventions
    Doxycycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2023-05-24
    Completion
    2030-01-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Acute Coronary Syndrome; Pulmonary Hypertension (Diagnosis)
    InterventionDoxycycline; Placebo
    PhasePhase 3
    Registry statusRecruiting

  • The Effect of Multiple Micronutrient Supplements in Reducing Anemia in Women of Reproductive Age

    NCT05682261 · start 2023-03-23

    Registered record
    Registry ID
    NCT05682261
    Conditions
    Anemia
    Interventions
    UNIMMAP-MMS; IFA; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-03-23
    Completion
    2023-10-17
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnemia
    InterventionUNIMMAP-MMS; IFA; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Therapeutic Implications of Acutaping on Nausea and Vomiting During Pregnancy

    NCT06259747 · start 2023-02-03

    Registered record
    Registry ID
    NCT06259747
    Conditions
    Nausea; Vomiting of Pregnancy
    Interventions
    Acutaping; Doxylamine and Pyridoxine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-02-03
    Completion
    2023-12-15
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNausea; Vomiting of Pregnancy
    InterventionAcutaping; Doxylamine and Pyridoxine
    PhaseNot applicable
    Registry statusCompleted

  • Board Game Project for Adolescents with Tourette Syndrome

    NCT05566236 · start 2022-09-20

    Registered record
    Registry ID
    NCT05566236
    Conditions
    Tourette Syndrome in Adolescence; Social Adjustment; Psychosocial Functioning
    Interventions
    board game
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-09-20
    Completion
    2024-08-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTourette Syndrome in Adolescence; Social Adjustment; Psychosocial Functioning
    Interventionboard game
    PhaseNot applicable
    Registry statusCompleted

  • Safety of Administering Isoniazid to SLE Patients to Prevent TB

    NCT06618573 · start 2022-08-15

    Registered record
    Registry ID
    NCT06618573
    Conditions
    Tuberculosis; Systemic Lupus Erythematosus
    Interventions
    Isoniazid/Pyridoxine; Saccharum Lactis
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Recruiting
    Start
    2022-08-15
    Completion
    2025-12-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Systemic Lupus Erythematosus
    InterventionIsoniazid/Pyridoxine; Saccharum Lactis
    PhasePhase 2 / Phase 3
    Registry statusRecruiting

  • One-month Latent Tuberculosis Treatment for Renal Transplant Candidates

    NCT05411744 · start 2022-07-01

    Registered record
    Registry ID
    NCT05411744
    Conditions
    Latent Tuberculosis; End Stage Renal Disease; Renal Transplant Candidate for Right Kidney; Renal Transplant Candidate for Left Kidney
    Interventions
    1 month Rifapentine, Isoniazid and Vitamin B6
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2022-07-01
    Completion
    2029-06-30
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLatent Tuberculosis; End Stage Renal Disease; Renal Transplant Candidate for Right Kidney; Renal Transplant Candidate for Left Kidney
    Intervention1 month Rifapentine, Isoniazid and Vitamin B6
    PhasePhase 4
    Registry statusActive not recruiting

  • Evaluation of Collagen-based Medical Device Treatment Combined With Physiotherapy in Subjects With Achilles Tendinopathy.

    NCT05464498 · start 2022-06-13

    Registered record
    Registry ID
    NCT05464498
    Conditions
    Tendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    Interventions
    MD-Tissue Collagen Medical Device; eccentric strengthening protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-06-13
    Completion
    2026-11-01
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTendinopathy; Insertional Achilles Tendinopathy; Achilles Tendinopathy; Peritendinitis
    InterventionMD-Tissue Collagen Medical Device; eccentric strengthening protocol
    PhaseNot applicable
    Registry statusRecruiting

  • Micronutrient Supplement for Nurse Burnout

    NCT05363410 · start 2022-05-01

    Registered record
    Registry ID
    NCT05363410
    Conditions
    Burnout, Professional; Stress, Psychological
    Interventions
    MagnéVie B6®; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-05-01
    Completion
    2023-04-30
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurnout, Professional; Stress, Psychological
    InterventionMagnéVie B6®; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Evaluation of Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine and Cyanocobalamin as Therapy for Vertigo

    NCT05221892 · start 2021-11-22

    Registered record
    Registry ID
    NCT05221892
    Conditions
    Vertigo
    Interventions
    Gamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin; Ginger
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-11-22
    Completion
    2023-03-31
    Enrolment
    334

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVertigo
    InterventionGamma-aminobutyric acid tartarate, glutamic acid, dibasic calcium phosphate, thiamine nitrate, pyridoxine chloride and cyanocobalamin; Ginger
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of PDE MAX

    NCT04672226 · start 2021-06-01

    Registered record
    Registry ID
    NCT04672226
    Conditions
    Pyridoxine Dependant Epilepsy
    Interventions
    PDE MAX
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2023-07-31
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyridoxine Dependant Epilepsy
    InterventionPDE MAX
    PhaseNot applicable
    Registry statusCompleted

  • Sumor as Adjuvant Therapy in Treatment-resistant Major Depression

    NCT04832178 · start 2021-06-01

    Registered record
    Registry ID
    NCT04832178
    Conditions
    Major Depressive Disorder
    Interventions
    SUMOR; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-06-01
    Completion
    2024-06-01
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionSUMOR; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Vitamin B Complex Improved Exercise Performance and Anti-fatigue

    NCT05586295 · start 2021-03-03

    Registered record
    Registry ID
    NCT05586295
    Conditions
    Exercise Performance; Fatigue
    Interventions
    Placebo; EX plus
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-03-03
    Completion
    2021-06-26
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExercise Performance; Fatigue
    InterventionPlacebo; EX plus
    PhaseNot applicable
    Registry statusCompleted