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AMR Drug RepurposingSmart Screeningresearch prototype

Ergocalciferol

FDA-approved product (capsule, oral), marketed as Deltalin, Drisdol, Ergocalciferol and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ergocalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hypoparathyroidism
  • Hypophosphatemia
  • Hypophosphatemic rickets

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
FDA pharmacologic class
Provitamin D2 Compound FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ergocalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ergocalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Vitamin D Supplementation on Inflammation and Cardiometabolic Risk Factors in Obese Adolescents

    NCT01217840 · start 2010-09

    Registered record
    Registry ID
    NCT01217840
    Conditions
    Obesity
    Interventions
    Drisdol (Ergocalciferol) Vitamin D2; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionDrisdol (Ergocalciferol) Vitamin D2; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Ergocalciferol on Erythropoetin Stimulating Agent Dose

    NCT01263028 · start 2010-08

    Registered record
    Registry ID
    NCT01263028
    Conditions
    Chronic Kidney Disease Stages 3-5
    Interventions
    Ergocalciferol supplementation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-08
    Completion
    2011-09
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease Stages 3-5
    InterventionErgocalciferol supplementation
    PhaseNot applicable
    Registry statusTerminated

  • Vitamin D Homeostasis in Sarcoidosis

    NCT03621553 · start 2010-07-01

    Registered record
    Registry ID
    NCT03621553
    Conditions
    Sarcoidosis; Vitamin D Insufficiency
    Interventions
    Ergocalciferol; Placebo; Calcium Citrate with Vitamin D2
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2010-07-01
    Completion
    2026-12-30
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoidosis; Vitamin D Insufficiency
    InterventionErgocalciferol; Placebo; Calcium Citrate with Vitamin D2
    PhasePhase 4
    Registry statusRecruiting

  • Feasibility and Effectiveness of Micronutrients as Palliative Care Therapy in Patients With Congestive Heart Failure

    NCT01474486 · start 2010-04

    Registered record
    Registry ID
    NCT01474486
    Conditions
    Congestive Heart Failure; Ischemic Cardiomyopathy
    Interventions
    Micronutrients
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-04
    Completion
    2016-02
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongestive Heart Failure; Ischemic Cardiomyopathy
    InterventionMicronutrients
    PhaseNot applicable
    Registry statusCompleted

  • Identification of Markers for Determining the Efficacy of Vitamin D Receptor Activator Therapy in Stage 3/4 CKD Patients

    NCT02018133 · start 2009-12

    Registered record
    Registry ID
    NCT02018133
    Conditions
    CKD Stage 3/4
    Interventions
    Vitamin D 2mg daily for 2 weeks oral paricalcitol; Placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-12
    Completion
    2012-06
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCKD Stage 3/4
    InterventionVitamin D 2mg daily for 2 weeks oral paricalcitol; Placebo
    PhaseNot recorded
    Registry statusCompleted

  • Phase III Trial of High Dose vs. Standard Dose Vit D2 With Docetaxel in Met Breast ca

    NCT00944424 · start 2009-07

    Registered record
    Registry ID
    NCT00944424
    Conditions
    Breast Cancer
    Interventions
    Docetaxel + High dose Vitamin D2; Docetaxel + Standard dose Vitamin D2
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2009-07
    Completion
    2012-07
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionDocetaxel + High dose Vitamin D2; Docetaxel + Standard dose Vitamin D2
    PhasePhase 3
    Registry statusUnknown

  • Calcium, Vitamin D and Metformin to Treat Insulin Resistance in Obese African American Adolescent Females

    NCT01107808 · start 2009-06

    Registered record
    Registry ID
    NCT01107808
    Conditions
    Insulin Resistance; Insulin Sensitivity; Obesity; Vitamin D Deficiency
    Interventions
    Calcium and Vit D; Metformin, Vit D and Calcium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2009-06
    Completion
    2011-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsulin Resistance; Insulin Sensitivity; Obesity; Vitamin D Deficiency
    InterventionCalcium and Vit D; Metformin, Vit D and Calcium
    PhaseNot applicable
    Registry statusWithdrawn

  • Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation

    NCT00882401 · start 2009-04

    Registered record
    Registry ID
    NCT00882401
    Conditions
    Chronic Kidney Disease; Vitamin D Deficiency
    Interventions
    Ergocalciferol (Vitamin D); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-04
    Completion
    2010-10
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Vitamin D Deficiency
    InterventionErgocalciferol (Vitamin D); Placebo
    PhasePhase 4
    Registry statusCompleted

  • Treatment of Vitamin D Deficiency in Patients With Rheumatoid Arthritis

    NCT01426347 · start 2009-01

    Registered record
    Registry ID
    NCT01426347
    Conditions
    Rheumatoid Arthritis; Vitamin D Deficiency
    Interventions
    Placebo sugar pill; Ergocalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-01
    Completion
    2012-01
    Enrolment
    139

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis; Vitamin D Deficiency
    InterventionPlacebo sugar pill; Ergocalciferol
    PhaseNot applicable
    Registry statusCompleted

  • The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria

    NCT00508898 · start 2008-05

    Registered record
    Registry ID
    NCT00508898
    Conditions
    Systemic Lupus Erythematosus; Nephritis; Proteinuria
    Interventions
    Calcitriol; Multivitamin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2008-05
    Completion
    2009-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSystemic Lupus Erythematosus; Nephritis; Proteinuria
    InterventionCalcitriol; Multivitamin
    PhasePhase 4
    Registry statusWithdrawn

  • Vitamin D Levels in Children With IBD

    NCT00621257 · start 2008-01

    Registered record
    Registry ID
    NCT00621257
    Conditions
    Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis
    Interventions
    ergocalciferol; Cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-01
    Completion
    2011-03
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis
    Interventionergocalciferol; Cholecalciferol
    PhaseNot applicable
    Registry statusTerminated

  • Effect of Different Vitamin D Vitamers on Vitamin D Status

    NCT02860663 · start 2007-08

    Registered record
    Registry ID
    NCT02860663
    Conditions
    Vitamin D Status
    Interventions
    Vitamin D3; Vitamin D2; 25OHD
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-08
    Completion
    2008-04
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Status
    InterventionVitamin D3; Vitamin D2; 25OHD
    PhaseNot applicable
    Registry statusCompleted

  • hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

    NCT00742235 · start 2007-07

    Registered record
    Registry ID
    NCT00742235
    Conditions
    Healthy Subjects; Vitamin D Deficiency
    Interventions
    ergocalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-07
    Completion
    2012-01
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects; Vitamin D Deficiency
    Interventionergocalciferol
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Approaches to Correcting Vitamin D Inadequacy and Maintaining Adequacy

    NCT00692120 · start 2007-02

    Registered record
    Registry ID
    NCT00692120
    Conditions
    Vitamin D Inadequacy; Vitamin D Deficiency
    Interventions
    Cholecalciferol (vitamin D3); Ergocalciferol (vitamin D2); Ergocalciferol (vitamin D2); Cholecalciferol (vitamin D3); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-02
    Completion
    2008-11
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Inadequacy; Vitamin D Deficiency
    InterventionCholecalciferol (vitamin D3); Ergocalciferol (vitamin D2); Ergocalciferol (vitamin D2); Cholecalciferol (vitamin D3) +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin D Deficiency in Elderly African American Women in Central Texas

    NCT01971411 · start 2006-03

    Registered record
    Registry ID
    NCT01971411
    Conditions
    Vitamin D Deficiency; Osteoporosis; Osteopenia
    Interventions
    Calcium 500mg with 200 IU Vitamin D - 2 tablets daily; Blood levels of Vitamin D, Serum CTX, Mg, Ca++ and iPTH; Usual sun exposure documentation; Dietary intake of calcium, vitamin D, magnesium
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-03
    Completion
    2007-05
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Osteoporosis; Osteopenia
    InterventionCalcium 500mg with 200 IU Vitamin D - 2 tablets daily; Blood levels of Vitamin D, Serum CTX, Mg, Ca++ and iPTH; Usual sun exposure documentation; Dietary intake of calcium, vitamin D, magnesium
    PhaseNot recorded
    Registry statusCompleted