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AMR Drug RepurposingSmart Screeningresearch prototype

Ergocalciferol

FDA-approved product (capsule, oral), marketed as Deltalin, Drisdol, Ergocalciferol and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ergocalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hypoparathyroidism
  • Hypophosphatemia
  • Hypophosphatemic rickets

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
FDA pharmacologic class
Provitamin D2 Compound FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ergocalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ergocalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Vitamin D Raising and Maintaining Blood Serum 25(OH)D3 Levels

    NCT03099759 · start 2016-06-27

    Registered record
    Registry ID
    NCT03099759
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-06-27
    Completion
    2017-05-31
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin D and Calcium Supplement Attenuate Bone Loss Among HIV- Infected Patients Receiving Tenofovir Disoproxil Fumarate, Lamivudine or Emtricitabine and Efavirenz

    NCT02827643 · start 2016-06

    Registered record
    Registry ID
    NCT02827643
    Conditions
    Bone Density
    Interventions
    TDF/3TC or FTC/EFV plus Calcium and vitamin D supplement; TDF/3TC or FTC/EFV
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-06
    Completion
    2017-06
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Density
    InterventionTDF/3TC or FTC/EFV plus Calcium and vitamin D supplement; TDF/3TC or FTC/EFV
    PhaseNot applicable
    Registry statusUnknown

  • The Effect of Vitamin D Repletion on Kidney Stone Risk

    NCT02752841 · start 2016-05-01

    Registered record
    Registry ID
    NCT02752841
    Conditions
    Calculi
    Interventions
    Nutritional vitamin D repletion and maintenance
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2016-05-01
    Completion
    2019-05-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCalculi
    InterventionNutritional vitamin D repletion and maintenance
    PhaseNot applicable
    Registry statusTerminated

  • GAD-Alum (Diamyd) Administered Into Lymph Nodes in Combination With Vitamin D in Type 1 Diabetes (DIAGNODE-1)

    NCT02352974 · start 2015-01

    Registered record
    Registry ID
    NCT02352974
    Conditions
    Diabetes Mellitus, Type 1
    Interventions
    GAD-Alum; Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-01
    Completion
    2019-10
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 1
    InterventionGAD-Alum; Vitamin D
    PhasePhase 1
    Registry statusCompleted

  • Training Intervention in a Controlled Population of Frail Elderly

    NCT02331459 · start 2013-12

    Registered record
    Registry ID
    NCT02331459
    Conditions
    Physical Activity
    Interventions
    Multicomponent training intervention; Nutritional intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-12
    Completion
    2015-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhysical Activity
    InterventionMulticomponent training intervention; Nutritional intervention
    PhaseNot applicable
    Registry statusCompleted

  • Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease

    NCT01578473 · start 2013-05-23

    Registered record
    Registry ID
    NCT01578473
    Conditions
    Peyronie's Disease
    Interventions
    Vitamin D2; Vitamin E; Testosterone Pellets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-05-23
    Completion
    2017-11-13
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeyronie's Disease
    InterventionVitamin D2; Vitamin E; Testosterone Pellets
    PhasePhase 1
    Registry statusCompleted

  • Wheezing in Black Preterm Infants: Impact of Vitamin D Supplementation Strategy

    NCT01601847 · start 2013-01

    Registered record
    Registry ID
    NCT01601847
    Conditions
    Wheezing; Allergy
    Interventions
    Cholecalciferol; Cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2017-03-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWheezing; Allergy
    InterventionCholecalciferol; Cholecalciferol
    PhasePhase 4
    Registry statusCompleted

  • Pharmacokinetic Comparison of Vitamin's D2 and D3 in Stage 5 Chronic Kidney Disease Patients on Chronic Hemodialysis

    NCT01675557 · start 2012-09

    Registered record
    Registry ID
    NCT01675557
    Conditions
    Chronic Kidney Disease
    Interventions
    Vitamin D3; Vitamin D2; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease
    InterventionVitamin D3; Vitamin D2; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder

    NCT01633853 · start 2012-07

    Registered record
    Registry ID
    NCT01633853
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D2; 1,25(OH)2 Vit D3
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-07
    Completion
    2015-09
    Enrolment
    204

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D2; 1,25(OH)2 Vit D3
    PhasePhase 4
    Registry statusCompleted

  • Effect of Vitamin D Supplementation on Coronary Calcification and Parathyroid Hormone in CKD Patients

    NCT01672047 · start 2012-04

    Registered record
    Registry ID
    NCT01672047
    Conditions
    Chronic Kidney Disease; Vitamin D Deficiency
    Interventions
    Vitamin D2
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2015-12
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Vitamin D Deficiency
    InterventionVitamin D2
    PhaseNot applicable
    Registry statusUnknown

  • Evaluating Vitamin D Content in Mushrooms

    NCT01815437 · start 2012-01

    Registered record
    Registry ID
    NCT01815437
    Conditions
    Vitamin D Deficiency
    Interventions
    Mushroom Vitamin D2; Cholecalciferol; Vitamin D2 - Ergocalciferol; Mushroom Extract
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01
    Completion
    2013-06
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionMushroom Vitamin D2; Cholecalciferol; Vitamin D2 - Ergocalciferol; Mushroom Extract
    PhaseNot applicable
    Registry statusCompleted

  • Bioavailability and Biological Effects of Vitamin D2 Contained in Mushroom

    NCT01488734 · start 2011-11

    Registered record
    Registry ID
    NCT01488734
    Conditions
    Vitamin D Deficiency; Metabolic Syndrome; Prediabetes
    Interventions
    Mushroom with 600 IU vitamin D2; Mushroom with 4000 IU Vitamin D2; 600 IU Vitamin D3 and untreated mushroom; 4000 IU Vitamin D3 and untreated mushroom; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-11
    Completion
    2013-09
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Metabolic Syndrome; Prediabetes
    InterventionMushroom with 600 IU vitamin D2; Mushroom with 4000 IU Vitamin D2; 600 IU Vitamin D3 and untreated mushroom; 4000 IU Vitamin D3 and untreated mushroom +1 more
    PhaseNot applicable
    Registry statusCompleted

  • D Vitamin Intervention in VA

    NCT01375660 · start 2011-05

    Registered record
    Registry ID
    NCT01375660
    Conditions
    Impaired Fasting Glucose; Impaired Glucose Tolerance; Vitamin D Insufficiency
    Interventions
    Placebo; 50K vitamin D2
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-05
    Completion
    2014-11
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpaired Fasting Glucose; Impaired Glucose Tolerance; Vitamin D Insufficiency
    InterventionPlacebo; 50K vitamin D2
    PhaseNot applicable
    Registry statusCompleted

  • Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function

    NCT01320722 · start 2011-03

    Registered record
    Registry ID
    NCT01320722
    Conditions
    Renal Function; Endothelial Function; Blood Pressure; Overweight; Obesity
    Interventions
    Vitamin D ergocalciferol; Probenecid; Allopurinol; Placebo; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-03
    Completion
    2015-06
    Enrolment
    242

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Function; Endothelial Function; Blood Pressure; Overweight +1 more
    InterventionVitamin D ergocalciferol; Probenecid; Allopurinol; Placebo +1 more
    PhasePhase 3
    Registry statusCompleted

  • Vitamin D Deficiency in Adolescent Girls

    NCT01180946 · start 2010-09

    Registered record
    Registry ID
    NCT01180946
    Conditions
    Healthy; Vitamin D Deficiency
    Interventions
    ergocalciferol; placebo pill
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-09
    Completion
    2013-04
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Vitamin D Deficiency
    Interventionergocalciferol; placebo pill
    PhaseNot applicable
    Registry statusCompleted