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AMR Drug RepurposingSmart Screeningresearch prototype

Ergocalciferol

FDA-approved product (capsule, oral), marketed as Deltalin, Drisdol, Ergocalciferol and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ergocalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hypoparathyroidism
  • Hypophosphatemia
  • Hypophosphatemic rickets

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
FDA pharmacologic class
Provitamin D2 Compound FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ergocalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ergocalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity

    NCT00288873 · start 2006-02

    Registered record
    Registry ID
    NCT00288873
    Conditions
    Vitamin D Deficiency; Secondary Hyperparathyroidism; Obesity
    Interventions
    Ergocalciferol; Cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-02
    Completion
    2007-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Secondary Hyperparathyroidism; Obesity
    InterventionErgocalciferol; Cholecalciferol
    PhasePhase 4
    Registry statusCompleted

  • Treatment of Hypovitaminosis D in Rheumatoid Arthritis

    NCT00423358 · start 2005-02

    Registered record
    Registry ID
    NCT00423358
    Conditions
    Rheumatoid Arthritis; Hypovitaminosis D
    Interventions
    Vitamin D; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-02
    Completion
    2009-02
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis; Hypovitaminosis D
    InterventionVitamin D; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Vitamin D Supplementation on Antimycobacterial Immunity

    NCT00157066 · start 2002-12

    Registered record
    Registry ID
    NCT00157066
    Conditions
    Tuberculosis
    Interventions
    Ergocalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2002-12
    Completion
    2006-09
    Enrolment
    230

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionErgocalciferol
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin D Administration in the Nursing Home

    NCT00204919 · start 2001-06

    Registered record
    Registry ID
    NCT00204919
    Conditions
    Vitamin D Deficiency; Osteoporosis
    Interventions
    Vitamin D; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2001-06
    Completion
    2004-11
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Osteoporosis
    InterventionVitamin D; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Studies With 1,25-Dihydroxycholecalciferol

    NCT00001151 · start 1976-03

    Registered record
    Registry ID
    NCT00001151
    Conditions
    Hypocalcemia; Rickets
    Interventions
    1,25-Dihydroxycholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    1976-03
    Completion
    2009-10
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypocalcemia; Rickets
    Intervention1,25-Dihydroxycholecalciferol
    PhasePhase 2
    Registry statusTerminated