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AMR Drug RepurposingSmart Screeningresearch prototype

Mupirocin

FDA-approved product (ointment, topical), marketed as Bactroban, Centany, Mupirocin.

Registered studies
50+
Lab records
16
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Mupirocin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Impetigo
  • Infection
  • Nasal congestion

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antibiotics for topical use; Other nasal preparations
FDA pharmacologic class
RNA Synthetase Inhibitor Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D06AX09; FDA class RNA Synthetase Inhibitor Antibacterial

Repurposing investigation

Mupirocin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA75.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli82.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae71.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 6 of 10 lab records
  • E. coli: measured active in 1 of 2 lab records
  • K. pneumoniae: measured active in 2 of 4 lab records
Open Mupirocin in ChEMBL Registered studies below
Show the 16 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mupirocin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Detection, Education, Research and Decolonization Without Isolation in Long-term Care Facilities

    NCT01302210 · start 2010-10

    Registered record
    Registry ID
    NCT01302210
    Conditions
    Methicillin Resistant Staphylococcus Aureus
    Interventions
    Decolonization
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-10
    Completion
    2014-11
    Enrolment
    22,302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus
    InterventionDecolonization
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Intranasal Mupirocin on Rate of Staphylococcus Aureus Surgical Site Infection Following Cesarean Sections

    NCT01152593 · start 2010-07

    Registered record
    Registry ID
    NCT01152593
    Conditions
    Surgical Wound Infection; Cesarean Section; Staphylococcus Aureus
    Interventions
    Mupirocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-07
    Completion
    2014-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection; Cesarean Section; Staphylococcus Aureus
    InterventionMupirocin
    PhaseNot applicable
    Registry statusUnknown

  • Risk of Methicillin-resistant S.Aureus (MRSA) Infections in MRSA Carrier Under Introduction of Rapid MRSA Screening

    NCT01918813 · start 2009-11

    Registered record
    Registry ID
    NCT01918813
    Conditions
    Inflammatory Bowel Disease; Hepatobiliary Disease; Pancreas Disease
    Interventions
    vancomycin, mupirocin ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-11
    Completion
    2012-02
    Enrolment
    662

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammatory Bowel Disease; Hepatobiliary Disease; Pancreas Disease
    Interventionvancomycin, mupirocin ointment
    PhaseNot applicable
    Registry statusCompleted

  • Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community

    NCT00966446 · start 2009-09

    Registered record
    Registry ID
    NCT00966446
    Conditions
    MRSA - Methicillin Resistant Staphylococcus Aureus Infection
    Interventions
    Unsupervised Decolonization; Supervised Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2014-12
    Enrolment
    223

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA - Methicillin Resistant Staphylococcus Aureus Infection
    InterventionUnsupervised Decolonization; Supervised Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)

    NCT00980980 · start 2009-09

    Registered record
    Registry ID
    NCT00980980
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Chlorhexidine bath and nasal mupirocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-09
    Enrolment
    74,256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionChlorhexidine bath and nasal mupirocin
    PhaseNot applicable
    Registry statusCompleted

  • United States Pharmacovigilence Retapamulin-Prescribing

    NCT01153880 · start 2008-12

    Registered record
    Registry ID
    NCT01153880
    Conditions
    Skin Infections, Bacterial
    Interventions
    Retapamulin; Co-prescription of retapamulin and topical mupirocin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-08
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Infections, Bacterial
    InterventionRetapamulin; Co-prescription of retapamulin and topical mupirocin
    PhaseNot recorded
    Registry statusCompleted

  • Topical Gentamicin Cream Versus Alternating Gentamicin and Mupirocin Cream in Peritoneal Dialysis

    NCT00751374 · start 2008-09

    Registered record
    Registry ID
    NCT00751374
    Conditions
    Rate of Exit Site Infection; Rate of Atypical Mycobacterial Infection; Rate of Peritoneal Dialysis
    Interventions
    gentamicin; gentamicin cream alternating with mupirocin cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-09
    Completion
    2014-10
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRate of Exit Site Infection; Rate of Atypical Mycobacterial Infection; Rate of Peritoneal Dialysis
    Interventiongentamicin; gentamicin cream alternating with mupirocin cream
    PhasePhase 4
    Registry statusUnknown

  • Staphylococcus Aureus Decolonization Study

    NCT00731783 · start 2008-07

    Registered record
    Registry ID
    NCT00731783
    Conditions
    Staphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus; MRSA Infection
    Interventions
    2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-12
    Enrolment
    183

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus +1 more
    Intervention2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Decolonization of Methicillin-resistant Staphylococcus Aureus (MRSA) Using Theraworx

    NCT00713674 · start 2008-03

    Registered record
    Registry ID
    NCT00713674
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Theraworx; mupirocin antibiotic ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2008-03
    Completion
    2009-02
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionTheraworx; mupirocin antibiotic ointment
    PhaseNot applicable
    Registry statusWithdrawn

  • A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA

    NCT00532324 · start 2008-02

    Registered record
    Registry ID
    NCT00532324
    Conditions
    Staphylococcus Aureus
    Interventions
    CA-MRSA Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionCA-MRSA Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy, Safety, and Tolerability of TD1414 2% Cream in Impetigo and Secondarily Infected Traumatic Lesions (SITL)

    NCT00626795 · start 2008-02

    Registered record
    Registry ID
    NCT00626795
    Conditions
    Impetigo; Secondarily Infected Traumatic Lesions
    Interventions
    TD1414 2% cream; TD1414 2% cream; Bactroban® (mupirocin) 2% cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-06
    Enrolment
    773

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpetigo; Secondarily Infected Traumatic Lesions
    InterventionTD1414 2% cream; TD1414 2% cream; Bactroban® (mupirocin) 2% cream
    PhasePhase 2
    Registry statusCompleted

  • Prospective Study of Methicillin-Resistant Staphylococcus Aureus (MRSA) Among HIV-Infected Persons

    NCT00631566 · start 2007-05

    Registered record
    Registry ID
    NCT00631566
    Conditions
    HIV Infections; Staphylococcal Infections
    Interventions
    Mupirocin (Bactroban) 2%; hexachlorophene (pHisoHex) 3%; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-05
    Completion
    2017-10
    Enrolment
    550

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Staphylococcal Infections
    InterventionMupirocin (Bactroban) 2%; hexachlorophene (pHisoHex) 3%; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection

    NCT00560599 · start 2007-04

    Registered record
    Registry ID
    NCT00560599
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    mupirocin and chlorhexidine; household cleaning and disinfection; mupirocin, chlorhexidine, & household cleaning/disinfection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2012-12
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionmupirocin and chlorhexidine; household cleaning and disinfection; mupirocin, chlorhexidine, & household cleaning/disinfection
    PhasePhase 3
    Registry statusCompleted

  • The Natural History of Community-Associated MRSA Infections and Decolonization Strategies

    NCT00513799 · start 2007-03

    Registered record
    Registry ID
    NCT00513799
    Conditions
    Abscesses; Furunculosis; Staphylococcus Aureus; Staphylococcal Skin Infections
    Interventions
    Mupirocin ointment; Chlorhexidine showers; Bleach baths (dilute); Intensive education on personal hygiene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscesses; Furunculosis; Staphylococcus Aureus; Staphylococcal Skin Infections
    InterventionMupirocin ointment; Chlorhexidine showers; Bleach baths (dilute); Intensive education on personal hygiene
    PhaseNot applicable
    Registry statusCompleted

  • A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections

    NCT01049438 · start 2006-08

    Registered record
    Registry ID
    NCT01049438
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    nasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-08
    Completion
    2009-09
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionnasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    PhaseNot applicable
    Registry statusCompleted