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AMR Drug RepurposingSmart Screeningresearch prototype

Dextromethorphan Polistirex

FDA-approved product (suspension, extended release, oral), marketed as Delsym, Dextromethorphan Polistirex.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Dextromethorphan Polistirex
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic disease
  • Common cold
  • Cough
  • Fever
  • Headache
  • Nasal congestion
  • Sinusitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other nervous system drugs; Opium alkaloids and derivatives
FDA pharmacologic class
Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA40.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis38.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dextromethorphan Polistirex in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dextromethorphan Polistirex with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)

    NCT01799941 · start 2013-02

    Registered record
    Registry ID
    NCT01799941
    Conditions
    Pseudobulbar Affect (PBA); Stroke; Dementia; Traumatic Brain Injury (TBI)
    Interventions
    Nuedexta (DM 20 mg/Q 10 mg)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-02
    Completion
    2015-05
    Enrolment
    367

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPseudobulbar Affect (PBA); Stroke; Dementia; Traumatic Brain Injury (TBI)
    InterventionNuedexta (DM 20 mg/Q 10 mg)
    PhasePhase 4
    Registry statusCompleted

  • Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease

    NCT01832350 · start 2012-08-28

    Registered record
    Registry ID
    NCT01832350
    Conditions
    Alzheimer's Disease; Pseudobulbar Affect (PBA)
    Interventions
    Nuedexta (20/10)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-08-28
    Completion
    2016-12-01
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease; Pseudobulbar Affect (PBA)
    InterventionNuedexta (20/10)
    PhasePhase 4
    Registry statusTerminated

  • Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease

    NCT01584440 · start 2012-08-13

    Registered record
    Registry ID
    NCT01584440
    Conditions
    Agitation; Alzheimer's Disease
    Interventions
    AVP-923-20; Placebo; AVP-923-30
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-08-13
    Completion
    2014-07-30
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAgitation; Alzheimer's Disease
    InterventionAVP-923-20; Placebo; AVP-923-30
    PhasePhase 2
    Registry statusCompleted

  • Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects

    NCT01651325 · start 2012-05

    Registered record
    Registry ID
    NCT01651325
    Conditions
    Pharmacokinetics of Isavuconazole; Pharmacokinetics of Dextromethorphan; Healthy Adult Volunteers
    Interventions
    Isavuconazole; dextromethorphan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-05
    Completion
    2012-05
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Dextromethorphan; Healthy Adult Volunteers
    InterventionIsavuconazole; dextromethorphan
    PhasePhase 1
    Registry statusCompleted

  • The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity

    NCT01361217 · start 2011-09

    Registered record
    Registry ID
    NCT01361217
    Conditions
    Drug-Drug Interaction; Healthy Volunteers
    Interventions
    Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-06
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-Drug Interaction; Healthy Volunteers
    InterventionFluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan
    PhaseNot applicable
    Registry statusCompleted

  • Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients

    NCT01553435 · start 2011-01

    Registered record
    Registry ID
    NCT01553435
    Conditions
    Pain; Opioid Tolerance; Analgesia Tolerance
    Interventions
    Dextromethorphan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2011-01
    Completion
    Not recorded
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Opioid Tolerance; Analgesia Tolerance
    InterventionDextromethorphan; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Biomarkers of CYP2D6 and CYP3A4 Variability in Pediatrics

    NCT01118858 · start 2010-04

    Registered record
    Registry ID
    NCT01118858
    Conditions
    Drug Metabolism Phenotype
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-04
    Completion
    2015-10
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Metabolism Phenotype
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Pharmacokinetics in Morbid Obesity After Bariatric Surgery

    NCT01086722 · start 2010-02

    Registered record
    Registry ID
    NCT01086722
    Conditions
    Morbid Obesity; Overweight
    Interventions
    "karolinska cocktail"
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2010-02
    Completion
    2013-03
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity; Overweight
    Intervention"karolinska cocktail"
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer

    NCT01017939 · start 2010-01

    Registered record
    Registry ID
    NCT01017939
    Conditions
    Prostate Neoplasms
    Interventions
    Abiraterone acetate; Prednisone; Dextromethorphan hydrobromide; Theophylline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-01
    Completion
    2012-04
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Neoplasms
    InterventionAbiraterone acetate; Prednisone; Dextromethorphan hydrobromide; Theophylline
    PhasePhase 1
    Registry statusCompleted

  • Study of the Effect of Single Doses of MK2637 and Dextromethorphan on Cerebral Cortex Excitability (2637-008)

    NCT00934466 · start 2009-07

    Registered record
    Registry ID
    NCT00934466
    Conditions
    Schizophrenia
    Interventions
    MK2637; Comparator: MK2637; Comparator: Placebo; Comparator: Dextromethorphan; Comparator: Dextromethorphan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionMK2637; Comparator: MK2637; Comparator: Placebo; Comparator: Dextromethorphan +1 more
    PhasePhase 1
    Registry statusCompleted

  • A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

    NCT00728468 · start 2008-09

    Registered record
    Registry ID
    NCT00728468
    Conditions
    Advanced Malignant Solid Tumors
    Interventions
    PF-00299804
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-09
    Completion
    2014-07
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdvanced Malignant Solid Tumors
    InterventionPF-00299804
    PhasePhase 1
    Registry statusCompleted

  • Combined Therapy of Methadone and Dextromethrophan

    NCT01189097 · start 2008-04

    Registered record
    Registry ID
    NCT01189097
    Conditions
    Opioid Abuse
    Interventions
    Dextromethorphan; Dextromethorphan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2008-04
    Completion
    2011-09
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Abuse
    InterventionDextromethorphan; Dextromethorphan
    PhasePhase 3
    Registry statusUnknown

  • Study of Cobimetinib in Participants With Solid Tumors

    NCT00467779 · start 2007-05

    Registered record
    Registry ID
    NCT00467779
    Conditions
    Solid Tumor
    Interventions
    cobimetinib; dextromethorphan; midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-05
    Completion
    2014-04
    Enrolment
    119

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSolid Tumor
    Interventioncobimetinib; dextromethorphan; midazolam
    PhasePhase 1
    Registry statusCompleted

  • Treatment of Acute Sinusitis

    NCT00377403 · start 2006-10

    Registered record
    Registry ID
    NCT00377403
    Conditions
    Acute Respiratory Infections; Acute Rhinosinusitis
    Interventions
    Acetaminophen; Amoxicillin; Dextromethorphan hydrobromide with guaifenesin; Guaifenesin; Pseudoephedrine Sustained Action; Saline spray (0.65%)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10
    Completion
    2010-08
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Infections; Acute Rhinosinusitis
    InterventionAcetaminophen; Amoxicillin; Dextromethorphan hydrobromide with guaifenesin; Guaifenesin +2 more
    PhasePhase 4
    Registry statusCompleted

  • Add-On Therapy to Risperidonein Schizophrenia

    NCT01189006 · start 2005-01

    Registered record
    Registry ID
    NCT01189006
    Conditions
    Schizophrenia
    Interventions
    Dextromethorphan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2005-01
    Completion
    2008-12
    Enrolment
    161

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionDextromethorphan
    PhasePhase 2 / Phase 3
    Registry statusCompleted