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AMR Drug RepurposingSmart Screeningresearch prototype

Cefazolin Sodium

FDA-approved product (injectable, injection), marketed as Ancef, Ancef In Dextrose 5% In Plastic Container, Ancef In Plastic Container and 5 more.

Registered studies
50+
Lab records
4
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Cefazolin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Endocarditis
  • Infection
  • Prostatitis
  • Sepsis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
First-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DB04

Repurposing investigation

Cefazolin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA78.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli88.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. A stereoisomer of this medicine was in the model's training data.
  • K. pneumoniae90.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis45.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 2 of 4 lab records
Open Cefazolin Sodium in ChEMBL Registered studies below
Show the 4 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefazolin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Medical Versus Surgical Treatment for Peritonsillar Abscesses

    NCT04998513 · start 2022-01

    Registered record
    Registry ID
    NCT04998513
    Conditions
    Peritonsillar Abscess; Surgical Incision
    Interventions
    Medical Management Alone Arm; Surgical Arm
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2022-01
    Completion
    2022-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritonsillar Abscess; Surgical Incision
    InterventionMedical Management Alone Arm; Surgical Arm
    PhaseNot applicable
    Registry statusWithdrawn

  • Modulation of Microbiota Metabolism in Cardiac Surgery Patients

    NCT04921436 · start 2021-10-03

    Registered record
    Registry ID
    NCT04921436
    Conditions
    Multiple Organ Dysfunction
    Interventions
    cardiac surgery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-10-03
    Completion
    2023-07-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Organ Dysfunction
    Interventioncardiac surgery
    PhaseNot applicable
    Registry statusCompleted

  • Continuous Stitches Versus Simple Interrupted Stitches for Anterior Colporrhaphy

    NCT05449054 · start 2021-07-01

    Registered record
    Registry ID
    NCT05449054
    Conditions
    Cystocele; Cystocele, Midline; Vaginal Prolapse; Prolaps Bladder; Pelvic Organ Prolapse
    Interventions
    Anterior colporrhaphy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-07-01
    Completion
    2023-07-01
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystocele; Cystocele, Midline; Vaginal Prolapse; Prolaps Bladder +1 more
    InterventionAnterior colporrhaphy
    PhaseNot applicable
    Registry statusUnknown

  • BonE and Joint Infections - Simplifying Treatment in Children Trial

    NCT04538053 · start 2021-06-01

    Registered record
    Registry ID
    NCT04538053
    Conditions
    Bone Infection; Septic Arthritis; Bone and Joint Infection; Osteomyelitis
    Interventions
    Oral cefalexin only; IV cefazolin or IV flucloxacillin followed by oral cefalexin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-06-01
    Completion
    2026-12
    Enrolment
    285

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Infection; Septic Arthritis; Bone and Joint Infection; Osteomyelitis
    InterventionOral cefalexin only; IV cefazolin or IV flucloxacillin followed by oral cefalexin
    PhasePhase 4
    Registry statusRecruiting

  • SSI Rates in Patients Undergoing Mastectomy Without Reconstruction- A Multicenter, Double-blinded RCT.

    NCT04577846 · start 2020-11-01

    Registered record
    Registry ID
    NCT04577846
    Conditions
    Surgical Site Infection
    Interventions
    Cephalexin 500 MG; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2020-11-01
    Completion
    2022-12-31
    Enrolment
    384

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionCephalexin 500 MG; Placebo
    PhasePhase 3
    Registry statusUnknown

  • Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery

    NCT05959603 · start 2020-05-31

    Registered record
    Registry ID
    NCT05959603
    Conditions
    Infection
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2020-05-31
    Completion
    2026-12-01
    Enrolment
    363

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection
    InterventionVancomycin
    PhasePhase 3
    Registry statusRecruiting

  • Empirical Antibiotics in Acute Inflammatory Gallbladder Disease

    NCT04321902 · start 2020-04-02

    Registered record
    Registry ID
    NCT04321902
    Conditions
    Cholecystitis, Acute
    Interventions
    Laparoscopic cholecystectomy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-04-02
    Completion
    2021-12-30
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystitis, Acute
    InterventionLaparoscopic cholecystectomy
    PhaseNot applicable
    Registry statusUnknown

  • Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation

    NCT04280237 · start 2020-03

    Registered record
    Registry ID
    NCT04280237
    Conditions
    Liver Transplant Infection; Surgical Site Infection; Antibiotic Prophylaxis; Cephazolin Adverse Reaction
    Interventions
    Blood samples
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2020-03
    Completion
    2020-03-18
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplant Infection; Surgical Site Infection; Antibiotic Prophylaxis; Cephazolin Adverse Reaction
    InterventionBlood samples
    PhaseNot recorded
    Registry statusWithdrawn

  • Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome

    NCT06030713 · start 2019-03-01

    Registered record
    Registry ID
    NCT06030713
    Conditions
    Microbial Colonization; Antibiotic Side Effect; Cesarean Section Complications
    Interventions
    Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-03-01
    Completion
    2023-03-01
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMicrobial Colonization; Antibiotic Side Effect; Cesarean Section Complications
    InterventionCefazolin
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term

    NCT03801252 · start 2018-12-12

    Registered record
    Registry ID
    NCT03801252
    Conditions
    Obesity; Induction of Labor Affected Fetus / Newborn
    Interventions
    Cefazolin; Placebo; Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2018-12-12
    Completion
    2021-06-01
    Enrolment
    186

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Induction of Labor Affected Fetus / Newborn
    InterventionCefazolin; Placebo; Azithromycin
    PhaseEarly phase 1
    Registry statusCompleted

  • Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions

    NCT03578965 · start 2018-07-13

    Registered record
    Registry ID
    NCT03578965
    Conditions
    Premalignant Vulvar Lesion; Benign Vulvar Lesion
    Interventions
    Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-07-13
    Completion
    2021-11-23
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremalignant Vulvar Lesion; Benign Vulvar Lesion
    InterventionCefazolin
    PhasePhase 2
    Registry statusCompleted

  • Application of Intra-operative Prophylactic Antibiotics/Antiseptics in Chinese Breast Reconstruction Patients

    NCT03742908 · start 2018-06-16

    Registered record
    Registry ID
    NCT03742908
    Conditions
    Breast Neoplasms
    Interventions
    Cefazolin/clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-06-16
    Completion
    2021-10-31
    Enrolment
    291

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Neoplasms
    InterventionCefazolin/clindamycin
    PhaseNot applicable
    Registry statusUnknown

  • Skeletal Muscle and Adipose Tissue Study

    NCT03190668 · start 2018-05-29

    Registered record
    Registry ID
    NCT03190668
    Conditions
    Idiopathic Scoliosis
    Interventions
    Bolus dose of Cefazolin; Continuous Cefazolin drip; Paraspinal muscle microdialysis catheters; Subcutaneous microdialysis catheters
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-05-29
    Completion
    2022-06-23
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIdiopathic Scoliosis
    InterventionBolus dose of Cefazolin; Continuous Cefazolin drip; Paraspinal muscle microdialysis catheters; Subcutaneous microdialysis catheters
    PhasePhase 4
    Registry statusCompleted

  • Preoperative Antibiotics for Carpal Tunnel Release Surgery

    NCT03432858 · start 2018-05-17

    Registered record
    Registry ID
    NCT03432858
    Conditions
    Carpal Tunnel Syndrome
    Interventions
    Vancomycin; Cefazolin; Saline Solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-05-17
    Completion
    2020-12-14
    Enrolment
    184

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome
    InterventionVancomycin; Cefazolin; Saline Solution
    PhasePhase 4
    Registry statusCompleted

  • Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial

    NCT03283878 · start 2017-10-24

    Registered record
    Registry ID
    NCT03283878
    Conditions
    Arthropathy of Knee; Antibiotic Prophylaxis
    Interventions
    Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-24
    Completion
    2025-08-22
    Enrolment
    1,770

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthropathy of Knee; Antibiotic Prophylaxis
    InterventionCefazolin
    PhasePhase 4
    Registry statusCompleted