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AMR Drug RepurposingSmart Screeningresearch prototype

Cefazolin Sodium

FDA-approved product (injectable, injection), marketed as Ancef, Ancef In Dextrose 5% In Plastic Container, Ancef In Plastic Container and 5 more.

Registered studies
50+
Lab records
4
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Cefazolin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Endocarditis
  • Infection
  • Prostatitis
  • Sepsis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
First-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DB04

Repurposing investigation

Cefazolin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA78.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli88.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. A stereoisomer of this medicine was in the model's training data.
  • K. pneumoniae90.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis45.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 2 of 4 lab records
Open Cefazolin Sodium in ChEMBL Registered studies below
Show the 4 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefazolin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery

    NCT03071913 · start 2017-09-20

    Registered record
    Registry ID
    NCT03071913
    Conditions
    Central Nervous System Neoplasm; Localized Brain Neoplasm; Metastatic Malignant Neoplasm in the Brain; Recurrent Brain Neoplasm
    Interventions
    Biospecimen Collection; Laboratory Biomarker Analysis
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-09-20
    Completion
    2023-01-12
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Nervous System Neoplasm; Localized Brain Neoplasm; Metastatic Malignant Neoplasm in the Brain; Recurrent Brain Neoplasm
    InterventionBiospecimen Collection; Laboratory Biomarker Analysis
    PhaseNot recorded
    Registry statusCompleted

  • Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)

    NCT03094663 · start 2017-02-28

    Registered record
    Registry ID
    NCT03094663
    Conditions
    Knee Arthropathy
    Interventions
    Bupivacaine with epinephrine; Methylprednisolone; Cefazolin; 8 MHz. Chiba needle; Bupivacaine with Dexamethasone; Bupivacaine 25cc; Bupivacaine 20cc; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-02-28
    Completion
    2018-09-01
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Arthropathy
    InterventionBupivacaine with epinephrine; Methylprednisolone; Cefazolin; 8 MHz. Chiba needle +4 more
    PhasePhase 4
    Registry statusCompleted

  • The Efficacy of Prolonged Antibiotic Therapy for the Prevention of Relapsing Peritonitis in Peritoneal Dialysis Patients With High Dialysis Effluent Bacterial DNA Fragment Levels

    NCT02593201 · start 2016-02-26

    Registered record
    Registry ID
    NCT02593201
    Conditions
    Peritoneal Dialysis
    Interventions
    Extended antibiotics (cefazolin or ceftazidime); Usual antibiotics (cefazolin or ceftazidime)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-02-26
    Completion
    2019-06-30
    Enrolment
    358

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritoneal Dialysis
    InterventionExtended antibiotics (cefazolin or ceftazidime); Usual antibiotics (cefazolin or ceftazidime)
    PhasePhase 4
    Registry statusCompleted

  • Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection

    NCT02503904 · start 2015-10

    Registered record
    Registry ID
    NCT02503904
    Conditions
    Surgical Site Infections; Venous Thromboembolism
    Interventions
    Concomitant Tumescent Antibiotic Delivery & IV Delivery; Subcutaneous Tumescent Infiltration; cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2015-10
    Completion
    2019-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infections; Venous Thromboembolism
    InterventionConcomitant Tumescent Antibiotic Delivery & IV Delivery; Subcutaneous Tumescent Infiltration; cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia

    NCT02502877 · start 2015-07

    Registered record
    Registry ID
    NCT02502877
    Conditions
    Body Temperature Changes; Anesthesia
    Interventions
    Midazolam; Propofol; Standard; SpotOn
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-07
    Completion
    2016-03
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBody Temperature Changes; Anesthesia
    InterventionMidazolam; Propofol; Standard; SpotOn
    PhaseNot applicable
    Registry statusCompleted

  • Preoperative Antibiotic Dosing for Total Knee Arthroplasty

    NCT02433704 · start 2015-05

    Registered record
    Registry ID
    NCT02433704
    Conditions
    Acute Infection of Total Knee Replacement
    Interventions
    New Intraosseous; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2015-05
    Completion
    2018-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Infection of Total Knee Replacement
    InterventionNew Intraosseous; Cefazolin
    PhasePhase 4
    Registry statusWithdrawn

  • Antibiotic Prophylaxis for HDR Brachytherapy in the Treatment of Prostate Cancer

    NCT03862170 · start 2015-02-10

    Registered record
    Registry ID
    NCT03862170
    Conditions
    Prostate Cancer
    Interventions
    Ciprofloxacin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-02-10
    Completion
    2023-02
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionCiprofloxacin; Cefazolin
    PhasePhase 3
    Registry statusTerminated

  • The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection

    NCT02307006 · start 2015-01

    Registered record
    Registry ID
    NCT02307006
    Conditions
    Surgical Site Infection
    Interventions
    Ceftaroline; Cefazolin / Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2017-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionCeftaroline; Cefazolin / Vancomycin
    PhasePhase 4
    Registry statusUnknown

  • The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

    NCT02292082 · start 2014-11

    Registered record
    Registry ID
    NCT02292082
    Conditions
    Osteoarthritis
    Interventions
    Bupivacaine; Morphine; Methylprednisolone; Cefazolin; Normal saline; Midazolam; Propofol; Dexamethasone; 8 MHz. Chiba needle, 22 G / 4 inches
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-11
    Completion
    2016-08
    Enrolment
    111

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionBupivacaine; Morphine; Methylprednisolone; Cefazolin +5 more
    PhasePhase 4
    Registry statusCompleted

  • Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy

    NCT02579161 · start 2014-09

    Registered record
    Registry ID
    NCT02579161
    Conditions
    Kidney Stones
    Interventions
    cephalosporins; Fluoroquinolones; Clindamycin; Ampicillin/Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-09
    Completion
    2018-12
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Stones
    Interventioncephalosporins; Fluoroquinolones; Clindamycin; Ampicillin/Gentamicin
    PhasePhase 3
    Registry statusCompleted

  • Antibiotic Prophylaxis for Revision, Clean Head and Neck Surgery

    NCT01980082 · start 2014-01

    Registered record
    Registry ID
    NCT01980082
    Conditions
    Surgical Wound Infection
    Interventions
    Cefazolin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-01
    Completion
    2017-07-07
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection
    InterventionCefazolin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Early Amniotic Membrane Transplantation in Bacterial Keratitis

    NCT02716883 · start 2014-01

    Registered record
    Registry ID
    NCT02716883
    Conditions
    Keratitis of Both Eyes
    Interventions
    AMT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2014-01
    Completion
    2016-04
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratitis of Both Eyes
    InterventionAMT
    PhaseNot applicable
    Registry statusUnknown

  • Clinical Evaluation, Organic Response in Obesity Patients Subjected to Vertical Videolaparoscopy Gastroplasty With or Without Perioperative Cares Recommended by the Acerto Project. Randomized Study.

    NCT02113995 · start 2012-04

    Registered record
    Registry ID
    NCT02113995
    Conditions
    To Evaluate Clinical Results, Insulin Resistance and Inflammatory Response to Trauma in Morbidly Obese Patients
    Interventions
    ACERTO protocol vs Traditional care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04
    Completion
    2012-10
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTo Evaluate Clinical Results, Insulin Resistance and Inflammatory Response to Trauma in Morbidly Obese Patients
    InterventionACERTO protocol vs Traditional care
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy Assessment of Two Antibiotic Prophylaxis Regimens in Oral and Maxillofacial Trauma Surgery

    NCT01993134 · start 2011-12

    Registered record
    Registry ID
    NCT01993134
    Conditions
    Facial Fractures
    Interventions
    Cefazolin; Cefazolin Single Dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-12
    Completion
    2014-12
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFacial Fractures
    InterventionCefazolin; Cefazolin Single Dose
    PhasePhase 2
    Registry statusUnknown

  • Prevention of Arrhythmia Device Infection Trial (PADIT)

    NCT01613092 · start 2011-05

    Registered record
    Registry ID
    NCT01613092
    Conditions
    Arrhythmia
    Interventions
    Incremental; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2013-12
    Enrolment
    241

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    InterventionIncremental; Cefazolin
    PhasePhase 4
    Registry statusCompleted