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AMR Drug RepurposingSmart Screeningresearch prototype

Azithromycin

FDA-approved product (capsule, oral), marketed as Azasite, Azithromycin, Zithromax and 1 more.

Registered studies
50+
Lab records
20
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Azithromycin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial conjunctivitis
  • Bacterial disease
  • Cervicitis
  • Chronic bronchitis
  • Chronic obstructive pulmonary disease
  • Cystic fibrosis
  • Eye infection
  • HIV infection
  • Infection
  • Infectious otitis media
  • Otitis media
  • Pelvic Inflammatory Disease
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis
  • Sinusitis
  • and 2 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Macrolides; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01FA10; WHO ATC S01AA26

Repurposing investigation

Azithromycin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli89.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae88.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 7 of 9 lab records
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 8 of 8 lab records
Open Azithromycin in ChEMBL Registered studies below
Show the 20 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Azithromycin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Azithromycin in the Prevention of Lung Injury in Premature Newborn

    NCT03485703 · start 2012-08-28

    Registered record
    Registry ID
    NCT03485703
    Conditions
    Bronchopulmonary Dysplasia
    Interventions
    Azithromycin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-08-28
    Completion
    2016-04-13
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchopulmonary Dysplasia
    InterventionAzithromycin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Azithromycin Combination Therapy for the Treatment of Severe Malaria

    NCT01374126 · start 2011-07

    Registered record
    Registry ID
    NCT01374126
    Conditions
    Falciparum Malaria
    Interventions
    Artesunate; Azithromycin + Artesunate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-11
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFalciparum Malaria
    InterventionArtesunate; Azithromycin + Artesunate
    PhasePhase 2
    Registry statusCompleted

  • Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities

    NCT00980148 · start 2009-12-02

    Registered record
    Registry ID
    NCT00980148
    Conditions
    Chlamydial Infection
    Interventions
    Azithromycin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12-02
    Completion
    2014-05-27
    Enrolment
    567

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChlamydial Infection
    InterventionAzithromycin; Doxycycline
    PhasePhase 3
    Registry statusCompleted

  • Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea

    NCT01136850 · start 2009-11

    Registered record
    Registry ID
    NCT01136850
    Conditions
    Malaria in Pregnancy; Sexually Transmitted Infections; Anaemia
    Interventions
    chloroquine, sulphadoxine pyrimethamine, LLIN; azithromycin, sulphadoxine pyrimethamine, LLIN
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-11
    Completion
    2013-01
    Enrolment
    2,793

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria in Pregnancy; Sexually Transmitted Infections; Anaemia
    Interventionchloroquine, sulphadoxine pyrimethamine, LLIN; azithromycin, sulphadoxine pyrimethamine, LLIN
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children

    NCT00944515 · start 2009-08

    Registered record
    Registry ID
    NCT00944515
    Conditions
    Sinusitis
    Interventions
    placebo; azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    2015-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    Interventionplacebo; azithromycin
    PhaseNot applicable
    Registry statusCompleted

  • Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study

    NCT02557958 · start 2009-01

    Registered record
    Registry ID
    NCT02557958
    Conditions
    Chronic Obstructive Pulmonary Disease
    Interventions
    Azithromycin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2009-01
    Completion
    2018-12
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease
    InterventionAzithromycin; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Media

    NCT00796224 · start 2008-12

    Registered record
    Registry ID
    NCT00796224
    Conditions
    Acute Otitis Media
    Interventions
    60 mg/kg azithromycin ER; 30 mg/kg azithromycin IR
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-12
    Completion
    2009-02
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Otitis Media
    Intervention60 mg/kg azithromycin ER; 30 mg/kg azithromycin IR
    PhasePhase 2
    Registry statusCompleted

  • Safety and Efficacy Pilot Study of AzaSite (Azithromycin) in Subjects With Blepharitis

    NCT00629590 · start 2008-03

    Registered record
    Registry ID
    NCT00629590
    Conditions
    Blepharitis
    Interventions
    AzaSite®
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlepharitis
    InterventionAzaSite®
    PhasePhase 4
    Registry statusCompleted

  • Effect of Macrolide Antibiotics on Airway Inflammation in People With Chronic Obstructive Pulmonary Disease (COPD)

    NCT00549445 · start 2007-08

    Registered record
    Registry ID
    NCT00549445
    Conditions
    Pulmonary Disease, Chronic Obstructive
    Interventions
    Azithromycin; Placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-08
    Completion
    2012-07
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Disease, Chronic Obstructive
    InterventionAzithromycin; Placebo
    PhaseNot recorded
    Registry statusCompleted

  • Microorganism in Overactive Bladder Patients

    NCT00883818 · start 2007-01

    Registered record
    Registry ID
    NCT00883818
    Conditions
    Overactive Bladder
    Interventions
    azithromycin, doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-12
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOveractive Bladder
    Interventionazithromycin, doxycycline
    PhasePhase 4
    Registry statusCompleted

  • A Trial Of Azithromycin SR For The Treatment Of Acute Bronchitis And Secondary Infection Of Chronic Respiratory Diseases

    NCT00360464 · start 2006-10

    Registered record
    Registry ID
    NCT00360464
    Conditions
    Acute Bronchitis
    Interventions
    Azithromycin SR
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-10
    Completion
    2007-06
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Bronchitis
    InterventionAzithromycin SR
    PhasePhase 3
    Registry statusCompleted

  • Effects of Azithromycin on Airway Oxidative Stress Markers in Patients With Bronchiectasis

    NCT01463371 · start 2006-10

    Registered record
    Registry ID
    NCT01463371
    Conditions
    Bronchiectasis
    Interventions
    Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-10
    Completion
    2007-09
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchiectasis
    InterventionAzithromycin
    PhaseNot applicable
    Registry statusCompleted

  • A Randomized, Open Label, Clinical Trial of the Pharmacokinetics of Azithromycin Following a Single Dose of Azithromycin Sustained Release (2 Gram) or Commercial Azithromycin Tablet (500 mg) to Cancer Patients That Require Lung Surgery

    NCT00644176 · start 2004-11

    Registered record
    Registry ID
    NCT00644176
    Conditions
    Pharmacokinetics
    Interventions
    azithromycin immediate release (Zithromax); placebo; azithromycin SR; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-11
    Completion
    2005-04
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics
    Interventionazithromycin immediate release (Zithromax); placebo; azithromycin SR; placebo
    PhasePhase 2
    Registry statusCompleted

  • Azithromycin in Combination With Chloroquine Versus Chloroquine in the Eradication of Asymptomatic Plasmodium Falciparum

    NCT00082563 · start 2004-08

    Registered record
    Registry ID
    NCT00082563
    Conditions
    Malaria, Falciparum
    Interventions
    Azithromycin/Chloroquine; Chloroquine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2004-08
    Completion
    2004-11
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria, Falciparum
    InterventionAzithromycin/Chloroquine; Chloroquine
    PhasePhase 2
    Registry statusTerminated

  • Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine For The Treatment Of Uncomplicated, Symptomatic Falciparum Malaria In Southeast Asia

    NCT00084240 · start 2004-03

    Registered record
    Registry ID
    NCT00084240
    Conditions
    Malaria, Falciparum
    Interventions
    Azithromycin/Chloroquine; Sulfadoxine-Pyrimethamine/Chloroquine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2004-03
    Completion
    2005-04
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria, Falciparum
    InterventionAzithromycin/Chloroquine; Sulfadoxine-Pyrimethamine/Chloroquine
    PhasePhase 2 / Phase 3
    Registry statusTerminated