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AMR Drug RepurposingSmart Screeningresearch prototype

Vancomycin

FDA-approved product (solution, intravenous, oral), marketed as Vancomycin, Firvanq Kit, Tyzavan and 5 more.

Registered studies
50+
Lab records
118
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Vancomycin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Diarrhea
  • Endocarditis
  • Enterocolitis
  • Eye infection
  • Infection
  • Infective endocarditis
  • Respiratory tract infectious disorder
  • Sepsis
  • Skin disease
  • Skin infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antibiotics; Glycopeptide antibacterials
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XA01; WHO ATC A07AA09; WHO ATC S01AA28

Repurposing investigation

Vancomycin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli78.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae80.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis14.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 103 of 103 lab records
  • E. coli: measured active in 8 of 9 lab records
  • K. pneumoniae: measured active in 2 of 3 lab records
  • M. tuberculosis: measured active in 0 of 3 lab records
Open Vancomycin in ChEMBL Registered studies below
Show the 118 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vancomycin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intrapartum Effect of Vancomycin on Rectovaginal GBS Colonization

    NCT02814318 · start 2016-06

    Registered record
    Registry ID
    NCT02814318
    Conditions
    Group B Streptococcal Infection
    Interventions
    Vaginal and rectovaginal swab cultures
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2016-06
    Completion
    2019-10
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGroup B Streptococcal Infection
    InterventionVaginal and rectovaginal swab cultures
    PhaseNot recorded
    Registry statusTerminated

  • Cohort Study of German Hematological / Oncological Wards to Assess the Effect of Contact Precautions on Nosocomial Colonization With Vancomycin Resistant Enterococci

    NCT02623413 · start 2016-01

    Registered record
    Registry ID
    NCT02623413
    Conditions
    Vancomycin (Glycopeptide) Resistant Enterococcus (VRE); Cancer
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-01
    Completion
    2017-03
    Enrolment
    950

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVancomycin (Glycopeptide) Resistant Enterococcus (VRE); Cancer
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis

    NCT03615781 · start 2015-06-01

    Registered record
    Registry ID
    NCT03615781
    Conditions
    Arthritis, Septic
    Interventions
    Two week's arm - surgery; Four week's arm - surgery; Two week's arm - drugs; Four week's arm - drugs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2018-05-18
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Septic
    InterventionTwo week's arm - surgery; Four week's arm - surgery; Two week's arm - drugs; Four week's arm - drugs
    PhaseNot applicable
    Registry statusCompleted

  • FMT for Moderate to Severe CDI: A Randomised Study With Concurrent Stool Microbiota Assessment

    NCT02570477 · start 2015-01

    Registered record
    Registry ID
    NCT02570477
    Conditions
    Clostridium Difficile Infection
    Interventions
    Fecal Microbiota Transplantation; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2024-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile Infection
    InterventionFecal Microbiota Transplantation; Vancomycin
    PhaseNot applicable
    Registry statusUnknown

  • Intrapartum Vancomycin for Group B Streptococcus (GBS) Prophylaxis

    NCT02143154 · start 2014-10

    Registered record
    Registry ID
    NCT02143154
    Conditions
    GBS Positive; Women in Labor Given Vancomycin for Prophylaxis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-10
    Completion
    2018-10-03
    Enrolment
    77

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGBS Positive; Women in Labor Given Vancomycin for Prophylaxis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Topical Vancomycin for Neurosurgery Wound Prophylaxis

    NCT02284126 · start 2014-10

    Registered record
    Registry ID
    NCT02284126
    Conditions
    Infection; Surgery; Nervous System Diseases
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-10
    Completion
    2020-11
    Enrolment
    1,103

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Surgery; Nervous System Diseases
    InterventionVancomycin
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea

    NCT01987895 · start 2014-03-27

    Registered record
    Registry ID
    NCT01987895
    Conditions
    Clostridium Difficile Infection
    Interventions
    Cadazolid; Vancomycin; Cadazolid-matching placebo; Vancomycin-matching placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-03-27
    Completion
    2017-03-24
    Enrolment
    632

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile Infection
    InterventionCadazolid; Vancomycin; Cadazolid-matching placebo; Vancomycin-matching placebo
    PhasePhase 3
    Registry statusCompleted

  • Dose Escalation Trial of Intrasite Vancomycin Pharmacokinetics

    NCT01764750 · start 2013-01

    Registered record
    Registry ID
    NCT01764750
    Conditions
    Surgical Site Infection
    Interventions
    Intrasite Vancomycin; IV Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2013-01
    Completion
    2013-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionIntrasite Vancomycin; IV Vancomycin
    PhasePhase 1
    Registry statusTerminated

  • Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Community Acquired Pneumonia (CABP)

    NCT01669980 · start 2012-10

    Registered record
    Registry ID
    NCT01669980
    Conditions
    Infections; Pneumonia
    Interventions
    Ceftaroline fosamil; IV Ceftriaxone and Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections; Pneumonia
    InterventionCeftaroline fosamil; IV Ceftriaxone and Vancomycin
    PhasePhase 4
    Registry statusCompleted

  • Optimalisation of Therapeutic Drug Monitoring (TDM) of Vancomycin in Patients With Central Venous Port Devices

    NCT01661361 · start 2012-09

    Registered record
    Registry ID
    NCT01661361
    Conditions
    Catheter-related Infection
    Interventions
    blood levels
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2012-09
    Completion
    2012-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCatheter-related Infection
    Interventionblood levels
    PhaseNot recorded
    Registry statusUnknown

  • Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia

    NCT01515020 · start 2012-05

    Registered record
    Registry ID
    NCT01515020
    Conditions
    Nosocomial Infection; Healthcare-associated Infection
    Interventions
    vancomycin monotherapy; daptomycin monotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-05
    Completion
    2014-07
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNosocomial Infection; Healthcare-associated Infection
    Interventionvancomycin monotherapy; daptomycin monotherapy
    PhasePhase 3
    Registry statusTerminated

  • Effects of MRSA Bactericidal Gel To Promote Healing and Eliminate MRSA in cSSTI Vancogel(TM)

    NCT00945152 · start 2011-07-15

    Registered record
    Registry ID
    NCT00945152
    Conditions
    Bacterial Infections; Wounds
    Interventions
    Vancomycin 1.25-1.50% in a complex gel formulation trademarked Vancogel(R); Placebo, complex gel formulation without Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-07-15
    Completion
    2024-12-15
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections; Wounds
    InterventionVancomycin 1.25-1.50% in a complex gel formulation trademarked Vancogel(R); Placebo, complex gel formulation without Vancomycin
    PhasePhase 2
    Registry statusUnknown

  • A Study of Ceftobiprole in Patients With Fever and Neutropenia.

    NCT00529282 · start 2007-10

    Registered record
    Registry ID
    NCT00529282
    Conditions
    Fever; Neutropenia; Gram-positive Bacterial Infections; Pseudomonas Infection
    Interventions
    Ceftobiprole Medocaril; Cefepime with or without vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2007-10
    Completion
    2008-01
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFever; Neutropenia; Gram-positive Bacterial Infections; Pseudomonas Infection
    InterventionCeftobiprole Medocaril; Cefepime with or without vancomycin
    PhasePhase 3
    Registry statusTerminated

  • Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxis

    NCT00967941 · start 2007-08

    Registered record
    Registry ID
    NCT00967941
    Conditions
    MRSA Infections
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-08
    Completion
    2010-08
    Enrolment
    169

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA Infections
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

    NCT00424190 · start 2007-02

    Registered record
    Registry ID
    NCT00424190
    Conditions
    Bacterial Infections
    Interventions
    IV Vancomycin plus IV Aztreonam; Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-02
    Completion
    2007-11
    Enrolment
    698

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    InterventionIV Vancomycin plus IV Aztreonam; Ceftaroline
    PhasePhase 3
    Registry statusCompleted