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AMR Drug RepurposingSmart Screeningresearch prototype

Vancomycin

FDA-approved product (solution, intravenous, oral), marketed as Vancomycin, Firvanq Kit, Tyzavan and 5 more.

Registered studies
50+
Lab records
118
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Vancomycin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Diarrhea
  • Endocarditis
  • Enterocolitis
  • Eye infection
  • Infection
  • Infective endocarditis
  • Respiratory tract infectious disorder
  • Sepsis
  • Skin disease
  • Skin infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antibiotics; Glycopeptide antibacterials
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XA01; WHO ATC A07AA09; WHO ATC S01AA28

Repurposing investigation

Vancomycin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli78.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae80.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis14.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 103 of 103 lab records
  • E. coli: measured active in 8 of 9 lab records
  • K. pneumoniae: measured active in 2 of 3 lab records
  • M. tuberculosis: measured active in 0 of 3 lab records
Open Vancomycin in ChEMBL Registered studies below
Show the 118 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vancomycin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia

    NCT04948463 · start 2021-11-15

    Registered record
    Registry ID
    NCT04948463
    Conditions
    Febrile Neutropenia
    Interventions
    Piperacillin and Tazobactam for Injection; Cefepime Injection; Ceftazidime Injection; Vancomycin Injection; Amikacin Injection; Ciprofloxacin; Piperacillin and Tazobactam for Injection; Cefepime Injection; Ceftazidime Injection; Vancomycin Injection; Amikacin Injection; Ciprofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-11-15
    Completion
    2025-12-17
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Neutropenia
    InterventionPiperacillin and Tazobactam for Injection; Cefepime Injection; Ceftazidime Injection; Vancomycin Injection +8 more
    PhasePhase 4
    Registry statusCompleted

  • Effect of Vancomycin After Catheter Replacement

    NCT04856878 · start 2021-06-01

    Registered record
    Registry ID
    NCT04856878
    Conditions
    Central Line-associated Bloodstream Infection (CLABSI); Catheter-related Bloodstream Infection
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-06-01
    Completion
    2024-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Line-associated Bloodstream Infection (CLABSI); Catheter-related Bloodstream Infection
    InterventionVancomycin
    PhasePhase 4
    Registry statusUnknown

  • Evaluating the Healing of Diabetic Foot Ulcers With Compounded Anti-Infective Irrigation Therapy

    NCT05076955 · start 2021-03-31

    Registered record
    Registry ID
    NCT05076955
    Conditions
    Diabetic Foot Ulcer
    Interventions
    vancomycin-tobramycin-itraconazole
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2021-03-31
    Completion
    2022-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Foot Ulcer
    Interventionvancomycin-tobramycin-itraconazole
    PhaseEarly phase 1
    Registry statusUnknown

  • Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion

    NCT04017468 · start 2019-10-15

    Registered record
    Registry ID
    NCT04017468
    Conditions
    Surgical Site Infection
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-10-15
    Completion
    2026-07-31
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionVancomycin
    PhasePhase 2
    Registry statusCompleted

  • Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty

    NCT04075526 · start 2019-10-01

    Registered record
    Registry ID
    NCT04075526
    Conditions
    Osteoarthritis
    Interventions
    Povidone iodine; Vancomycin powder; Conventional
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-10-01
    Completion
    2025-12-13
    Enrolment
    2,129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionPovidone iodine; Vancomycin powder; Conventional
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure

    NCT03845790 · start 2019-05-26

    Registered record
    Registry ID
    NCT03845790
    Conditions
    Surgical Site Infection
    Interventions
    Blood and microdialysis samples
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-05-26
    Completion
    2024-09-04
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionBlood and microdialysis samples
    PhasePhase 1
    Registry statusCompleted

  • Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens

    NCT03765528 · start 2019-01-01

    Registered record
    Registry ID
    NCT03765528
    Conditions
    Patients at High Risk of Antibacterial Treatment Upon Admission
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-01-01
    Completion
    2022-07-31
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients at High Risk of Antibacterial Treatment Upon Admission
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • A Study to Assess Efficacy and Safety of SER-287 in Adults With Active Mild-to-Moderate Ulcerative Colitis

    NCT03759041 · start 2018-12-19

    Registered record
    Registry ID
    NCT03759041
    Conditions
    Ulcerative Colitis
    Interventions
    Vancomycin Pre-Treatment; Placebo for Vancomycin Pre-Treatment; SER-287; Placebo for SER-287
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2018-12-19
    Completion
    2021-10-13
    Enrolment
    203

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUlcerative Colitis
    InterventionVancomycin Pre-Treatment; Placebo for Vancomycin Pre-Treatment; SER-287; Placebo for SER-287
    PhasePhase 2
    Registry statusTerminated

  • Vancomycin Pharmacokinetics in Patients on Peritoneal Dialysis

    NCT03685747 · start 2018-11-15

    Registered record
    Registry ID
    NCT03685747
    Conditions
    Peritoneal Dialysis-associated Peritonitis
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-11-15
    Completion
    2020-10-01
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritoneal Dialysis-associated Peritonitis
    InterventionVancomycin
    PhasePhase 1
    Registry statusCompleted

  • Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients

    NCT03438214 · start 2018-04-28

    Registered record
    Registry ID
    NCT03438214
    Conditions
    Gram-Positive Bacterial Infections; Nephrotoxicity; Sepsis
    Interventions
    Vancomycin Continuous infusion; Vancomycin Intermittent infusion
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-04-28
    Completion
    2022-12-01
    Enrolment
    222

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGram-Positive Bacterial Infections; Nephrotoxicity; Sepsis
    InterventionVancomycin Continuous infusion; Vancomycin Intermittent infusion
    PhasePhase 4
    Registry statusUnknown

  • Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial

    NCT03283878 · start 2017-10-24

    Registered record
    Registry ID
    NCT03283878
    Conditions
    Arthropathy of Knee; Antibiotic Prophylaxis
    Interventions
    Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-24
    Completion
    2025-08-22
    Enrolment
    1,770

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthropathy of Knee; Antibiotic Prophylaxis
    InterventionCefazolin
    PhasePhase 4
    Registry statusCompleted

  • Oral Vancomycin for Preventing Clostridium Difficile Recurrence

    NCT03200093 · start 2017-06-08

    Registered record
    Registry ID
    NCT03200093
    Conditions
    Clostridium Difficile Infection
    Interventions
    Oral Vancomycin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-06-08
    Completion
    2021-04-22
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile Infection
    InterventionOral Vancomycin; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Screening to Prophylax Against Clostridium Difficile Infection -

    NCT02996487 · start 2016-12-19

    Registered record
    Registry ID
    NCT02996487
    Conditions
    Clostridium Difficile Infection
    Interventions
    Vancomycin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-12-19
    Completion
    2023-06-28
    Enrolment
    1,294

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile Infection
    InterventionVancomycin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • FMT for MDRO Colonization After Infection in Renal Transplant Recipients

    NCT02922816 · start 2016-12-01

    Registered record
    Registry ID
    NCT02922816
    Conditions
    Infection Due to Resistant Organism
    Interventions
    Fecal Microbiota Transplant (FMT); Bowel preparation; Stool or perirectal swab sampling; Fasting
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2016-12-01
    Completion
    2021-12-03
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection Due to Resistant Organism
    InterventionFecal Microbiota Transplant (FMT); Bowel preparation; Stool or perirectal swab sampling; Fasting
    PhasePhase 1
    Registry statusTerminated

  • Intestinal Lavage for the Treatment of Severe C. Difficile Infections

    NCT02466698 · start 2016-08

    Registered record
    Registry ID
    NCT02466698
    Conditions
    Clostridium Difficile
    Interventions
    Intestinal Lavage; Vancomycin; PEG; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2016-08
    Completion
    2019-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClostridium Difficile
    InterventionIntestinal Lavage; Vancomycin; PEG; Metronidazole
    PhasePhase 2 / Phase 3
    Registry statusUnknown