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AMR Drug RepurposingSmart Screeningresearch prototype

Indapamide

FDA-approved product (tablet, oral), marketed as Indapamide, Lozol.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Indapamide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Congestive heart failure
  • Hypertension
  • Preeclampsia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Sulfonamides, plain
FDA pharmacologic class
Thiazide-like Diuretic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis67.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Indapamide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Indapamide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety of Perindopril 5 mg / Indapamide 1.25 mg / Amlodipine 5 mg Fixed Combination in Hypertension

    NCT05820880 · start 2019-05-06

    Registered record
    Registry ID
    NCT05820880
    Conditions
    Hypertension
    Interventions
    Fixed [Per/Ind/Aml]; Free [Per/Ind + Aml]
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-05-06
    Completion
    2022-02-23
    Enrolment
    532

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionFixed [Per/Ind/Aml]; Free [Per/Ind + Aml]
    PhasePhase 3
    Registry statusCompleted

  • Spironolactone Versus Indapamide in Obese and Hypertensive Patients

    NCT03626506 · start 2019-02-13

    Registered record
    Registry ID
    NCT03626506
    Conditions
    Hypertension
    Interventions
    Spironolactone; Indapamide; Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-02-13
    Completion
    2020-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionSpironolactone; Indapamide; Amlodipine
    PhaseNot applicable
    Registry statusUnknown

  • Oral dIuretics in Very Intensive Treatment, an Early Intervention in Outpatients With Heart Failure

    NCT03709160 · start 2018-10-15

    Registered record
    Registry ID
    NCT03709160
    Conditions
    Heart Failure; Congestive Heart Failure
    Interventions
    Bumetanide 1 MG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-10-15
    Completion
    2019-10-15
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure; Congestive Heart Failure
    InterventionBumetanide 1 MG
    PhasePhase 4
    Registry statusUnknown

  • Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients

    NCT03476616 · start 2018-09-01

    Registered record
    Registry ID
    NCT03476616
    Conditions
    Hypertension; Obesity
    Interventions
    Eplerenone (-based therapy) arm; Valsartan (-based therapy) arm
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-09-01
    Completion
    2025-06-30
    Enrolment
    198

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Obesity
    InterventionEplerenone (-based therapy) arm; Valsartan (-based therapy) arm
    PhasePhase 4
    Registry statusCompleted

  • Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study

    NCT03783754 · start 2018-08-09

    Registered record
    Registry ID
    NCT03783754
    Conditions
    Stroke; Cerebral Small Vessel Diseases; Intracerebral Hemorrhage; Vascular Dementia; Hypertension
    Interventions
    telmisartan 20 mg + amlodipine 2.5mg + indapamide 1.25mg; Placebo oral capsule
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2018-08-09
    Completion
    2021-03-21
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke; Cerebral Small Vessel Diseases; Intracerebral Hemorrhage; Vascular Dementia +1 more
    Interventiontelmisartan 20 mg + amlodipine 2.5mg + indapamide 1.25mg; Placebo oral capsule
    PhaseNot applicable
    Registry statusTerminated

  • Role of Active Deresuscitation After Resuscitation-2

    NCT03512392 · start 2018-04-10

    Registered record
    Registry ID
    NCT03512392
    Conditions
    Critical Illness; Sepsis; Trauma
    Interventions
    Conservative fluid and deresuscitation strategy; Usual care strategy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-04-10
    Completion
    2021-07-17
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritical Illness; Sepsis; Trauma
    InterventionConservative fluid and deresuscitation strategy; Usual care strategy
    PhaseNot applicable
    Registry statusCompleted

  • Treating Nocturnal Hypertension and Nocturia in African American Men

    NCT03319823 · start 2017-10-25

    Registered record
    Registry ID
    NCT03319823
    Conditions
    High Blood Pressure
    Interventions
    Thiazide Treatment Group; Intensified Thiazide Treatment Group; Combination Medication Treatment Group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-10-25
    Completion
    2021-02-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh Blood Pressure
    InterventionThiazide Treatment Group; Intensified Thiazide Treatment Group; Combination Medication Treatment Group
    PhasePhase 4
    Registry statusWithdrawn

  • Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial

    NCT02699645 · start 2017-09-28

    Registered record
    Registry ID
    NCT02699645
    Conditions
    Intracerebral Haemorrhage (ICH); Hypertension
    Interventions
    telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-09-28
    Completion
    2025-08-27
    Enrolment
    1,671

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Haemorrhage (ICH); Hypertension
    Interventiontelmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes

    NCT03747978 · start 2016-10-01

    Registered record
    Registry ID
    NCT03747978
    Conditions
    Diabetes Mellitus, Type 2; Hypertension
    Interventions
    Perindopril and Amlodipine; Perindopril-indapamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-10-01
    Completion
    2017-05-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 2; Hypertension
    InterventionPerindopril and Amlodipine; Perindopril-indapamide
    PhasePhase 4
    Registry statusCompleted

  • Fimasartan in the Senior Subjects

    NCT03246555 · start 2016-07-15

    Registered record
    Registry ID
    NCT03246555
    Conditions
    The Elderly (≥ 70 Years) With Essential Hypertension
    Interventions
    Fimasartan or Fimasartan/Hydrochlorothiazide; Perindopril or Perindopril/Indapamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-07-15
    Completion
    2019-12-09
    Enrolment
    241

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThe Elderly (≥ 70 Years) With Essential Hypertension
    InterventionFimasartan or Fimasartan/Hydrochlorothiazide; Perindopril or Perindopril/Indapamide
    PhasePhase 3
    Registry statusCompleted

  • Once-daily Fixed Combination of Three Antihypertensive Drugs

    NCT02710539 · start 2016-04

    Registered record
    Registry ID
    NCT02710539
    Conditions
    Arterial Hypertension
    Interventions
    perindopril, indapamide , amlodipine; Tripliam (perindopril, indapamide, amlodipine)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-04
    Completion
    2020-03
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArterial Hypertension
    Interventionperindopril, indapamide , amlodipine; Tripliam (perindopril, indapamide, amlodipine)
    PhasePhase 4
    Registry statusUnknown

  • Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)

    NCT02539810 · start 2015-09

    Registered record
    Registry ID
    NCT02539810
    Conditions
    Hypertension; Hypertension Resistant to Conventional Therapy; Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
    Interventions
    Renal artery Angioplasty plus stenting.; Anti hypertensive, statin and antiplatelet medication.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2015-09
    Completion
    2017-07
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Hypertension Resistant to Conventional Therapy; Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
    InterventionRenal artery Angioplasty plus stenting.; Anti hypertensive, statin and antiplatelet medication.
    PhasePhase 4
    Registry statusTerminated

  • Non-invasive Haemodynamic Assessment in Hypertension

    NCT01996085 · start 2013-01

    Registered record
    Registry ID
    NCT01996085
    Conditions
    Arterial Hypertension
    Interventions
    lisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide; Amlodipine; lisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide; Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2017-12
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArterial Hypertension
    Interventionlisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide +6 more
    PhaseNot applicable
    Registry statusCompleted

  • Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency

    NCT01172431 · start 2010-09

    Registered record
    Registry ID
    NCT01172431
    Conditions
    Hypertension; Renal Insufficiency
    Interventions
    Indapamide; Hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2013-12
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Renal Insufficiency
    InterventionIndapamide; Hydrochlorothiazide
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis

    NCT00691314 · start 2008-06

    Registered record
    Registry ID
    NCT00691314
    Conditions
    Stroke; Transient Ischemic Attack; Atherosclerosis; Stenosis; Stents
    Interventions
    Stent implantation (Wingspan, Coroflex, and TiTAN2); Standard medical treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-06
    Completion
    2010-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke; Transient Ischemic Attack; Atherosclerosis; Stenosis +1 more
    InterventionStent implantation (Wingspan, Coroflex, and TiTAN2); Standard medical treatment
    PhaseNot applicable
    Registry statusCompleted