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AMR Drug RepurposingSmart Screeningresearch prototype

Desmopressin Acetate

FDA-approved product (solution, nasal), marketed as Concentraid, Ddavp, Ddavp (Needs No Refrigeration) and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Desmopressin Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central diabetes insipidus
  • Diabetes insipidus
  • Enuresis
  • Head injury
  • Hemorrhage
  • Nasal congestion
  • Nocturia
  • Von Willebrand disease (hereditary or acquired)

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vasopressin and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA65.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae45.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Desmopressin Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Desmopressin Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Trial of Desmopressin on Nocturia in Obstructive Sleep Apnoea Patients

    NCT01530451 · start 2012-03

    Registered record
    Registry ID
    NCT01530451
    Conditions
    Nocturia; Obstructive Sleep Apnoea
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-03
    Completion
    2015-02
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia; Obstructive Sleep Apnoea
    InterventionDesmopressin; Placebo
    PhasePhase 3
    Registry statusTerminated

  • Study Investigating the Impact Burden of Nocturia Using the Nocturia Impact Diary

    NCT01552343 · start 2012-03

    Registered record
    Registry ID
    NCT01552343
    Conditions
    Nocturia
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-03
    Completion
    2012-06
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic

    NCT01742689 · start 2012-03

    Registered record
    Registry ID
    NCT01742689
    Conditions
    Renal Colic; Pain
    Interventions
    Desmopressin intranasal spray; Placebo intranasal spray; Indomethacin suppository
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2012-03
    Completion
    2013-03
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Colic; Pain
    InterventionDesmopressin intranasal spray; Placebo intranasal spray; Indomethacin suppository
    PhasePhase 3
    Registry statusUnknown

  • Perioperative Use of Desmopressin (DDAVP) in Breast Cancer

    NCT01606072 · start 2011-11

    Registered record
    Registry ID
    NCT01606072
    Conditions
    Breast Cancer
    Interventions
    Desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-11
    Completion
    2015-07
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionDesmopressin
    PhasePhase 2
    Registry statusCompleted

  • Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction

    NCT01382134 · start 2011-07

    Registered record
    Registry ID
    NCT01382134
    Conditions
    Platelet Dysfunction; Hemodilution; Mild Hypothermia; NSAID; Desmopressin
    Interventions
    Aspirin, desmopressin; Placebo, desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2013-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlatelet Dysfunction; Hemodilution; Mild Hypothermia; NSAID +1 more
    InterventionAspirin, desmopressin; Placebo, desmopressin
    PhaseNot applicable
    Registry statusCompleted

  • Desmopressin Melt: Impact on Sleep and Daytime Functioning

    NCT01645475 · start 2011-04

    Registered record
    Registry ID
    NCT01645475
    Conditions
    Monosymptomatic Nocturnal Enuresis
    Interventions
    Desmopressin lyophilisate (Melt)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMonosymptomatic Nocturnal Enuresis
    InterventionDesmopressin lyophilisate (Melt)
    PhasePhase 4
    Registry statusCompleted

  • A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).

    NCT01280188 · start 2011-01

    Registered record
    Registry ID
    NCT01280188
    Conditions
    Central Diabetes Insipidus
    Interventions
    Desmopressin Oral Melt; Desmopressin intranasal
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Diabetes Insipidus
    InterventionDesmopressin Oral Melt; Desmopressin intranasal
    PhasePhase 3
    Registry statusCompleted

  • Investigation of the Superiority Effect of Desmopressin to Placebo in Terms of Night Voids Reduction in Nocturia Adult Female Patients

    NCT01223937 · start 2010-11

    Registered record
    Registry ID
    NCT01223937
    Conditions
    Nocturia
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-11
    Enrolment
    268

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Comparative Trial to Investigate the Dose-Response of 4 Different Dose Levels of Minirin Melt and Placebo

    NCT01184859 · start 2010-07

    Registered record
    Registry ID
    NCT01184859
    Conditions
    Nocturia
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-07
    Completion
    2011-04
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia
    InterventionDesmopressin; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Study With Two Different Doses of Desmopressin Orally Lyophilisate Tablet With Nocturnal Enuresis

    NCT01078753 · start 2010-01

    Registered record
    Registry ID
    NCT01078753
    Conditions
    Nocturnal Enuresis
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-01
    Completion
    2010-09
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturnal Enuresis
    InterventionDesmopressin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Severe Aortic Stenosis and Acquired Von Willebrand´s Disease: The Impact of Desmopressin in Valve-Replacement Surgery

    NCT01994330 · start 2009-06

    Registered record
    Registry ID
    NCT01994330
    Conditions
    Acquired Von Willebrand Disease Secondary to Severe Aortic Stenosis; Heye´s Syndrome; Severe Aortic Stenosis
    Interventions
    desmopressin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-02
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcquired Von Willebrand Disease Secondary to Severe Aortic Stenosis; Heye´s Syndrome; Severe Aortic Stenosis
    Interventiondesmopressin
    PhasePhase 4
    Registry statusCompleted

  • Desmopressin as Treatment for Postoperative Bleeding After Cardiac Surgery

    NCT00885924 · start 2009-03

    Registered record
    Registry ID
    NCT00885924
    Conditions
    Hemorrhage; Postoperative Blood Loss
    Interventions
    Desmopressin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-03
    Completion
    2012-02
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemorrhage; Postoperative Blood Loss
    InterventionDesmopressin; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease

    NCT00806468 · start 2009-02

    Registered record
    Registry ID
    NCT00806468
    Conditions
    Parkinson Disease
    Interventions
    Desmotabs
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-02
    Completion
    2011-02
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson Disease
    InterventionDesmotabs
    PhasePhase 4
    Registry statusTerminated

  • Efficacy and Safety of Desmopressin (Nocturin®) 0.1 mg Tablets in Treatment of Nocturia in Participants With Benign Prostate Syndrome (BPS)

    NCT00902265 · start 2009-02

    Registered record
    Registry ID
    NCT00902265
    Conditions
    Nocturia Associated With Nocturnal Polyuria
    Interventions
    desmopressin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-02
    Completion
    2010-03
    Enrolment
    138

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNocturia Associated With Nocturnal Polyuria
    Interventiondesmopressin
    PhaseNot recorded
    Registry statusCompleted

  • Desmopressin in Cardiac Surgery

    NCT00337766 · start 2006-06

    Registered record
    Registry ID
    NCT00337766
    Conditions
    Hemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
    Interventions
    Desmopressin (DDAVP); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2010-09
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemorrhage; Blood Loss, Surgical; Postoperative Hemorrhage
    InterventionDesmopressin (DDAVP); Placebo
    PhasePhase 4
    Registry statusCompleted